Ausgabe 1/2020
Inhalt (23 Artikel)
Identification of inhibitors of the polo-box domain of polo-like kinase 1 from natural and semisynthetic compounds
Sara Abdelfatah, Edmond Fleischer, Anette Klinger, Vincent Kam Wai Wong, Thomas Efferth
Cytotoxicity of [HuArgI (co)-PEG5000]-induced arginine deprivation to ovarian Cancer cells is autophagy dependent
Ghenwa Nasreddine, Mirvat El-Sibai, Ralph J. Abi-Habib
Knockdown of FBXO22 inhibits melanoma cell migration, invasion and angiogenesis via the HIF-1α/VEGF pathway
Yufan Zheng, Hairong Chen, Yang Zhao, Xuping Zhang, Jinjin Liu, Yu Pan, Jin Bai, Hongwei Zhang
Tubulin colchicine site binding agent LL01 displays potent antitumor efficiency both in vitro and in vivo with suitable drug-like properties
Jing-De Wu, Ying-Jie Cui, Yi-Gang Zhou, Long-Qian Tang, Cheng-Mei Zhang, Zhao-Peng Liu
Discovery of a pyrimidine compound endowed with antitumor activity
Ludovica Taglieri, Francesco Saccoliti, Alice Nicolai, Giovanna Peruzzi, Valentina Noemi Madia, Valeria Tudino, Antonella Messore, Roberto Di Santo, Marco Artico, Samanta Taurone, Maurizio Salvati, Roberta Costi, Susanna Scarpa
Emodin induced necroptosis in the glioma cell line U251 via the TNF-α/RIP1/RIP3 pathway
Jiabin Zhou, Genhua Li, Guangkui Han, Song Feng, Yuhan Liu, Jun Chen, Chen Liu, Lei Zhao, Feng Jin
MicroRNA-101-3p suppresses proliferation and migration in hepatocellular carcinoma by targeting the HGF/c-Met pathway
Yang Liu, Juan Tan, Shuangyan Ou, Jun Chen, Limin Chen
Assessment of the cytotoxic effects of aporphine prototypes on head and neck cancer cells
Dorival Mendes Rodrigues-Junior, Nicolie Melanie de Almeida Pontes, Gabriela Estrela de Albuquerque, Viviane Carlin, Givago Prado Perecim, Cristiano Raminelli, André Luiz Vettore
Design, synthesis, and biological activity of TLR7-based compounds for chemotherapy-induced alopecia
Jincheng Yang, Kun Chen, Bin Wang, Liudi Wang, Shuya Qi, Weihua Wang
Pharmacological effects of the simultaneous and sequential combinations of trifluridine/tipiracil (TAS-102) and 5-fluorouracil in fluoropyrimidine-sensitive colon cancer cells
Paola Orlandi, Daniela Gentile, Marta Banchi, Federico Cucchiara, Teresa Di Desidero, Chiara Cremolini, Roberto Moretto, Alfredo Falcone, Guido Bocci
A phase I study of pexidartinib, a colony-stimulating factor 1 receptor inhibitor, in Asian patients with advanced solid tumors
Jih-Hsiang Lee, Tom Wei-Wu Chen, Chih-Hung Hsu, Yu-Hsin Yen, James Chih-Hsin Yang, Ann-Lii Cheng, Shun-ichi Sasaki, LiYin (Lillian) Chiu, Masahiro Sugihara, Tomoko Ishizuka, Toshihiro Oguma, Naoyuki Tajima, Chia-Chi Lin
A phase I study to determine the maximum tolerated dose of trifluridine/tipiracil and oxaliplatin in patients with refractory metastatic colorectal cancer: LUPIN study
Mitsukuni Suenaga, Takeru Wakatsuki, Tetsuo Mashima, Mariko Ogura, Takashi Ichimura, Eiji Shinozaki, Izuma Nakayama, Hiroki Osumi, Yumiko Ota, Daisuke Takahari, Keisho Chin, Hiroyuki Seimiya, Kensei Yamaguchi
A phase I, dose-escalation study of PF-06650808, an anti-Notch3 antibody–drug conjugate, in patients with breast cancer and other advanced solid tumors
Lee S. Rosen, Robert Wesolowski, Raffaele Baffa, Kai-Hsin Liao, Steven Y. Hua, Brenda L. Gibson, Steven Pirie-Shepherd, Anthony W. Tolcher
The effect of itraconazole on the pharmacokinetics of lorlatinib: results of a phase I, open-label, crossover study in healthy participants
Maulik Patel, Joseph Chen, Stephanie McGrory, Melissa O’Gorman, Sunil Nepal, Katherine Ginman, Yazdi K. Pithavala
TS-1 add-on therapy in Japanese patients with triple-negative breast cancer after neoadjuvant or adjuvant chemotherapy: a feasibility study
Kenichi Inoue, Shigenori E. Nagai, Tsuyoshi Saito, Takashi Sakurai, Kei Kimizuka, Hirofumi Yamada, Toru Kuroda, Satoshi Hata, Yasuo Yamazaki, Masato Kojima, Kazushige Futsuhara
A randomized phase 2 trial of apatinib vs observation as maintenance treatment following firstline induction chemotherapy in extensive stage small cell lung cancer
Hao Luo, Liang Zhang, Bo Yang, Yan Feng, Yanli Xiong, Shiheng Zhang, Xuemei Li, Chengyuan Qian, Wang Dong, Nan Dai
Germinal Immunogenetics predict treatment outcome for PD-1/PD-L1 checkpoint inhibitors
Sadal Refae, Jocelyn Gal, Nathalie Ebran, Josiane Otto, Delphine Borchiellini, Frederic Peyrade, Emmanuel Chamorey, Patrick Brest, Gérard Milano, Esma Saada-Bouzid
Sequential therapy with sorafenib and regorafenib for advanced hepatocellular carcinoma: a multicenter retrospective study in Japan
Sadahisa Ogasawara, Yoshihiko Ooka, Norio Itokawa, Masanori Inoue, Shinichiro Okabe, Atsuyoshi Seki, Yuki Haga, Masamichi Obu, Masanori Atsukawa, Ei Itobayashi, Hideaki Mizumoto, Nobuyuki Sugiura, Ryosaku Azemoto, Kengo Kanayama, Hiroaki Kanzaki, Susumu Maruta, Takahiro Maeda, Yuko Kusakabe, Masayuki Yokoyama, Kazufumi Kobayashi, Soichiro Kiyono, Masato Nakamura, Tomoko Saito, Eiichiro Suzuki, Shingo Nakamoto, Shin Yasui, Akinobu Tawada, Tetsuhiro Chiba, Makoto Arai, Tatsuo Kanda, Hitoshi Maruyama, Naoya Kato
Veliparib in ovarian cancer: a new synthetically lethal therapeutic approach
Stergios Boussios, Peeter Karihtala, Michele Moschetta, Charlotte Abson, Afroditi Karathanasi, Nikolaos Zakynthinakis-Kyriakou, Jake Edward Ryan, Matin Sheriff, Elie Rassy, Nicholas Pavlidis
Negative impact of malignant effusion on osimertinib treatment for non-small cell lung cancer harboring EGFR mutation
Takahisa Kawamura, Hirotsugu Kenmotsu, Haruki Kobayashi, Shota Omori, Kazuhisa Nakashima, Kazushige Wakuda, Akira Ono, Tateaki Naito, Haruyasu Murakami, Keita Mori, Masahiro Endo, Toshiaki Takahashi
The influence of direct-acting antivirals in hepatitis C virus related hepatocellular carcinoma after curative treatment
Yuan-Hung Kuo, Jing-Houng Wang, Kuo-Chin Chang, Chao-Hung Hung, Sheng-Nan Lu, Tsung-Hui Hu, Yi-Hao Yen, Kwong-Ming Kee, Chien-Hung Chen
Association between metastatic sites and first-line pembrolizumab treatment outcome for advanced non–small cell lung cancer with high PD-L1 expression: a retrospective multicenter cohort study
Hayato Kawachi, Motohiro Tamiya, Akihiro Tamiya, Seigo Ishii, Katsuya Hirano, Hirotaka Matsumoto, Yasushi Fukuda, Toshihide Yokoyama, Ryota Kominami, Daichi Fujimoto, Kazutaka Hosoya, Hidekazu Suzuki, Tomonori Hirashima, Masaki Kanazu, Nobuhiko Sawa, Junji Uchida, Mitsunori Morita, Takeshi Makio, Satoshi Hara, Toru Kumagai