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Investigational New Drugs

Ausgabe 4/2008

Inhalt (13 Artikel)

PRECLINICAL STUDIES

Cytotoxic effects of curcumin on osteosarcoma cell lines

Denise K. Walters, Roman Muff, Bettina Langsam, Walter Born, Bruno Fuchs

PRECLINICAL STUDIES

Identification of small molecules inducing apoptosis by cell-based assay using fission yeast deletion mutants

Kyung-Sook Chung, Nam-Hui Yim, Seung-Hee Lee, Shin-Jung Choi, Kyung-Sun Hur, Kwang-Lae Hoe, Dong-Uk Kim, Sondra Goehle, Hyung-Bae Kim, Kyung-Bin Song, Hyang-Sook Yoo, Ki-Hwan Bae, Julian Simon, Misun Won

PRECLINICAL STUDIES

The combination of gamma ionizing radiation and 8-Cl-cAMP induces synergistic cell growth inhibition and induction of apoptosis in human prostate cancer cells

Vesna Vučić, Ana Nićiforović, Miroslav Adžić, Marija B. Radojčić, Sabera Ruždijić

PRECLINICAL STUDIES

Murine leukemia P388 vinorelbine-resistant cell lines are sensitive to vinflunine

Ashish Aggarwal, Anna Kruczynski, Anthony Frankfurter, John J. Correia, Sharon Lobert

PHASE I STUDIES

A phase I and pharmacokinetic study of XK469R (NSC 698215), a quinoxaline phenoxypropionic acid derivative, in patients with refractory acute leukemia

Wendy Stock, Samir D. Undevia, Carol Bivins, Farhad Ravandi, Olatoyosi Odenike, Stefan Faderl, Elizabeth Rich, Gautam Borthakur, Lucy Godley, Srdan Verstovsek, Andrew Artz, William Wierda, Richard A. Larson, Yanming Zhang, Jorge Cortes, Mark J. Ratain, Francis J. Giles

PHASE I STUDIES

Phase I trial of pemetrexed plus oxaliplatin administered every other week in patients with metastatic cancer

Daniel G. Stover, A. Craig Lockhart, Jordan D. Berlin, Emily Chan, Alan B. Sandler, Jeffery A. Sosman, Victoria Middlebrook, Steven Nicol, Mace L. Rothenberg

PHASE I STUDIES

Phase I dose-escalation study of the thioxanthone SR271425 administered intravenously once every 3 weeks in patients with advanced malignancies

Priscila H. Goncalves, Francine High, Paul Juniewicz, Gareth Shackleton, Jing Li, Scott Boerner, Patricia M. LoRusso

PHASE I STUDIES

Phase I trial of docetaxel and thalidomide: a regimen based on metronomic therapeutic principles

Sharon L. Sanborn, Matthew M. Cooney, Afshin Dowlati, Joanna M. Brell, Smitha Krishnamurthi, Joseph Gibbons, Joseph A. Bokar, Charles Nock, Anne Ness, Scot C. Remick

PHASE II STUDIES

Biweekly administration of gemcitabine and cisplatin chemotherapy in patients with anthracycline and taxane-pretreated metastatic breast cancer

Faruk Tas, Nese Guney, Duygu Derin, Hakan Camlica, Adnan Aydiner, Erkan Topuz

PHASE II STUDIES

A phase 2 consortium (P2C) trial of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP) for advanced adenocarcinoma of the pancreas

Steven Attia, Jill Kolesar, Michelle R. Mahoney, Henry C. Pitot, Daniel Laheru, James Heun, Wei Huang, Jens Eickhoff, Charles Erlichman, Kyle D. Holen

PHASE II STUDIES

A phase II study of pemetrexed in patients with advanced hepatocellular carcinoma

Allen L. Cohn, J. William Myers, Steven Mamus, Charles Deur, Steven Nicol, Karen Hood, Muhammad M. Khan, Des Ilegbodu, Lina Asmar

PHASE II STUDIES

Salvage chemotherapy with mitomycin C, ifosfamide, and cisplatin (MIC) for previously treated metastatic or recurrent esophageal squamous cell carcinoma

Byeong-Bae Park, Young-Hyuck Im, In Gyu Hwang, Sang Cheol Lee, Jin Seok Ahn, Myung-Ju Ahn, Ho-Yeong Lim, Won Ki Kang, Keunchil Park

Open Access PHASE III STUDIES

Gastrointestinal ulceration as a possible side effect of bevacizumab which may herald perforation

J. Tol, A. Cats, L. Mol, M. Koopman, M. M. E. M. Bos, J. J. M. van der Hoeven, N. F. Antonini, J. H. J. M. van Krieken, C. J. A. Punt

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