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Zeitschrift

Investigational New Drugs

Investigational New Drugs 5/2019

Ausgabe 5/2019

Inhaltsverzeichnis ( 29 Artikel )

27.10.2018 | PRECLINICAL STUDIES | Ausgabe 5/2019

A novel humanized anti-PD-1 monoclonal antibody potentiates therapy in oral squamous cell carcinoma

Y. Cai, Fei Wang, Q. Liu, Z. Li, D. Li, Z. Sun

29.10.2018 | PRECLINICAL STUDIES | Ausgabe 5/2019

The bispecific anti-CD3 × anti-CD155 antibody mediates T cell immunotherapy for human prostate cancer

Huijun Zhao, Juan Ma, Ting Lei, Wanru Ma, Man Zhang

30.10.2018 | PRECLINICAL STUDIES | Ausgabe 5/2019

Lurbinectedin (PM01183), a selective inhibitor of active transcription, effectively eliminates both cancer cells and cancer stem cells in preclinical models of uterine cervical cancer

Eriko Yokoi, Seiji Mabuchi, Kotaro Shimura, Naoko Komura, Katsumi Kozasa, Hiromasa Kuroda, Ryoko Takahashi, Tomoyuki Sasano, Mahiru Kawano, Yuri Matsumoto, Michiko Kodama, Kae Hashimoto, Kenjiro Sawada, Tadashi Kimura

19.11.2018 | PRECLINICAL STUDIES | Ausgabe 5/2019

The novel PI3K inhibitor S1 synergizes with sorafenib in non-small cell lung cancer cells involving the Akt-S6 signaling

Juan Wang, Shumei Ma, Xiuhua Chen, Sanqi Zhang, Zhiyong Wang, Qibing Mei

22.11.2018 | PRECLINICAL STUDIES | Ausgabe 5/2019

Caffeic acid phenethyl ester exerts apoptotic and oxidative stress on human multiple myeloma cells

Elizabeth Hernandez Marin, Hana Paek, Mei Li, Yesung Ban, Marie Katie Karaga, Rangaiah Shashidharamurthy, Xinyu Wang

29.11.2018 | PRECLINICAL STUDIES | Ausgabe 5/2019 Open Access

The role of oxidative stress in 63 T-induced cytotoxicity against human lung cancer and normal lung fibroblast cell lines

Malgorzata Kucinska, Helena Mieszczak, Hanna Piotrowska-Kempisty, Mariusz Kaczmarek, Walter Granig, Marek Murias, Thomas Erker

29.11.2018 | PRECLINICAL STUDIES | Ausgabe 5/2019

A mediator of phosphorylated Smad2/3, evodiamine, in the reversion of TAF-induced EMT in normal colonic epithelial cells

Wanbin Yang, Xiuli Gong, Xiulian Wang, Chao Huang

04.12.2018 | PRECLINICAL STUDIES | Ausgabe 5/2019

A novel tetravalent bispecific antibody targeting programmed death 1 and tyrosine-protein kinase Met for treatment of gastric cancer

Weihua Hou, Qingyun Yuan, Xingxing Yuan, Yuxiong Wang, Wei Mo, Huijie Wang, Min Yu

13.12.2018 | PRECLINICAL STUDIES | Ausgabe 5/2019 Open Access

The availability of drug by liposomal drug delivery

Individual kinetics and tissue distribution of encapsulated and released drug in mice after administration of PEGylated liposomal prednisolone phosphate
Evelien A. W. Smits, José A. Soetekouw, Ebel H. E. Pieters, Coen J. P. Smits, Nicolette de Wijs-Rot, Herman Vromans

13.12.2018 | PRECLINICAL STUDIES | Ausgabe 5/2019

Modulator of the PI3K/Akt oncogenic pathway affects mTOR complex 2 in human adenocarcinoma cells

Blair P. Curless, Nne E. Uko, Diane F. Matesic

19.12.2018 | PRECLINICAL STUDIES | Ausgabe 5/2019

MICONIDINE acetate, a new selective and cytotoxic compound with synergic potential, induces cell cycle arrest and apoptosis in leukemia cells

Mariana Franzoni Maioral, Natália Marceli Stefanes, Álisson Bigolin, Gabriele Andressa Zatelli, Ana Cláudia Philippus, Miriam de Barcellos Falkenberg, Maria Cláudia Santos-Silva

04.01.2019 | PRECLINICAL STUDIES | Ausgabe 5/2019

MiR-181a, a new regulator of TGF-β signaling, can promote cell migration and proliferation in gastric cancer

Shaohua Ge, Haiyang Zhang, Ting Deng, Wu Sun, Tao Ning, Qian Fan, Yi Wang, Xinyi Wang, Qiumo Zhang, Zhengyang Zhou, Haiou Yang, Guoguang Ying, Yi Ba

04.01.2019 | PRECLINICAL STUDIES | Ausgabe 5/2019

Screening, identification of prostate cancer urinary biomarkers and verification of important spots

Huijun Zhao, Xuhong Zhao, Ting Lei, Man Zhang

05.01.2019 | PRECLINICAL STUDIES | Ausgabe 5/2019

Sensitization of colorectal cancer to irinotecan therapy by PARP inhibitor rucaparib

Titto Augustine, Radhashree Maitra, Jinghang Zhang, Jay Nayak, Sanjay Goel

05.01.2019 | PRECLINICAL STUDIES | Ausgabe 5/2019

Biodistribution, pharmacokinetics and radioimmunotherapy of 188Re-cetuximab in NCI-H292 human lung tumor-bearing nude mice

Ya-Jen Chang, Chung-Li Ho, Kai-Hung Cheng, Wan-I Kuo, Wan-Chi Lee, Keng-Li Lan, Chih-Hsien Chang

11.01.2019 | PRECLINICAL STUDIES | Ausgabe 5/2019

The rhenium(I)-diselenoether anticancer drug targets ROS, TGF-β1, VEGF-A, and IGF-1 in an in vitro experimental model of triple-negative breast cancers

Philippe Collery, Vijay Veena, Adhikesavan Harikrishnan, Didier Desmaele

15.01.2019 | PRECLINICAL STUDIES | Ausgabe 5/2019 Open Access

The cellular effects of novel triazine nitrogen mustards in glioblastoma LBC3, LN-18 and LN-229 cell lines

Rafał Krętowski, Danuta Drozdowska, Beata Kolesińska, Zbigniew Kamiński, Justyna Frączyk, Marzanna Cechowska-Pasko

19.01.2019 | PRECLINICAL STUDIES | Ausgabe 5/2019

In vitro and in vivo cytotoxic activity and human serum albumin interaction for a methoxy-styryl-thiosemicarbazone

Otávio Augusto Chaves, Isabela S. de Castro, Carla Marins Goulart, Myrtes S. S. Bellieny, José Carlos Netto-Ferreira, Juliana Echevarria-Lima, Aurea Echevarria

25.01.2019 | PRECLINICAL STUDIES | Ausgabe 5/2019

Nifuroxazide induces apoptosis, inhibits cell migration and invasion in osteosarcoma

Yi Luo, Anqi Zeng, Aiping Fang, Linjiang Song, Chen Fan, Chenjuan Zeng, Tinghong Ye, Hao Chen, Chongqi Tu, Yongmei Xie

01.02.2019 | PRECLINICAL STUDIES | Ausgabe 5/2019

Lopinavir-NO, a nitric oxide-releasing HIV protease inhibitor, suppresses the growth of melanoma cells in vitro and in vivo

Svetlana Paskas, Emanuela Mazzon, Maria Sofia Basile, Eugenio Cavalli, Yousef Al-Abed, Mingzhu He, Sara Rakocevic, Ferdinando Nicoletti, Sanja Mijatovic, Danijela Maksimovic-Ivanic

01.02.2019 | PRECLINICAL STUDIES | Ausgabe 5/2019

Modified ingenol semi-synthetic derivatives from Euphorbia tirucalli induce cytotoxicity on a large panel of human cancer cell lines

Viviane A. O Silva, Marcela N. Rosa, Olga Martinho, Amilcar Tanuri, João Paulo Lima, Luiz F. Pianowski, Rui M. Reis

01.02.2019 | PRECLINICAL STUDIES | Ausgabe 5/2019

Bispecific anti-CD3 x anti-B7-H3 antibody mediates T cell cytotoxic ability to human melanoma in vitro and in vivo

Juan Ma, Tengfei Shang, Pan Ma, Xin Sun, Jin Zhao, Ximing Sun, Man Zhang

25.01.2019 | PHASE I STUDIES | Ausgabe 5/2019

The antitumor efficacy of monomeric disintegrin obtustatin in S-180 sarcoma mouse model

Narine Ghazaryan, Naira Movsisyan, Joana Catarina Macedo, Sara Vaz, Naira Ayvazyan, Luis Pardo, Elsa Logarinho

06.02.2019 | PHASE I STUDIES | Ausgabe 5/2019

A phase I study of the antibody drug conjugate ASG-5ME, an SLC44A4-targeting antibody carrying auristatin E, in metastatic castration-resistant prostate cancer

Deaglan McHugh, Mario Eisenberger, Elisabeth I. Heath, Justine Bruce, Daniel C. Danila, Dana E. Rathkopf, Jarett Feldman, Susan F. Slovin, Banmeet Anand, Rong Chu, Jacqueline Lackey, Leonard Reyno, Emmanuel S. Antonarakis, Michael J. Morris

09.01.2019 | PHASE I STUDIES | Ausgabe 5/2019 Open Access

A phase I study of ontuxizumab, a humanized monoclonal antibody targeting endosialin, in Japanese patients with solid tumors

Toshihiko Doi, Takeshi Aramaki, Hirofumi Yasui, Kei Muro, Masafumi Ikeda, Takuji Okusaka, Yoshitaka Inaba, Kenya Nakai, Hiroki Ikezawa, Ryo Nakajima

26.10.2018 | PRECLINICAL STUDIES | Ausgabe 5/2019

Chemotherapy in pregnancy: exploratory study of the effects of paclitaxel on the expression of placental drug transporters

Paul Berveiller, Olivier Mir, Séverine A. Degrelle, Vassilis Tsatsaris, Lise Selleret, Jean Guibourdenche, Danièle Evain-Brion, Thierry Fournier, Sophie Gil

31.05.2018 | Phase III Studies | Ausgabe 5/2019

The drug lag and associated factors for orphan anticancer drugs in Japan compared to the United States

Hiroki Nakayama, Naoki Matsumaru, Katsura Tsukamoto

05.01.2019 | PHASE III STUDIES | Ausgabe 5/2019

Significant differences on submission lag following regulation reform for registration of novel therapeutic drugs in Taiwan

I-Chen Sun

05.01.2019 | REVIEW | Ausgabe 5/2019

Human antigen R and drug resistance in tumors

Fenghai Zhou, Fa Zhang, Chuan Zhou, Mengtian Liang, Zhonglin Cai, Haidi Lv, Wenjuan Li, Xupan Wei

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