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Investigational New Drugs

Ausgabe 6/2008

Inhalt (9 Artikel)

PRECLINICAL STUDIES

Anticancer activity of a peptide combination in gastrointestinal cancers targeting multiple neuropeptide receptors

Manu Jaggi, Sudhanand Prasad, Anu T. Singh, R. Praveen, Sarjana Dutt, Archana Mathur, Rajan Sharma, Neena Gupta, Rinku Ahuja, Rama Mukherjee, Anand C. Burman

PRECLINICAL STUDIES

Modulation of key signal transduction molecules by a novel peptide combination effective for the treatment of gastrointestinal carcinomas

Anu T. Singh, Manu Jaggi, Sudhanand Prasad, Sarjana Dutt, Gurvinder Singh, Kakali Datta, Praveen Rajendran, Vinod K. Sanna, Rama Mukherjee, Anand C. Burman

PRECLINICAL STUDIES

CPT21, a novel compound with anti-proliferative effect against gastric cancer cell SGC7901

Bo Zhang, Yu Luo, Qinjie Weng, Qiaojun He, Wei Lu, Bo Yang

PRECLINICAL STUDIES

Evaluation of the therapeutic efficacy of tripeptide tyroserleutide (YSL) for human hepatocarcinoma by in vivo hollow fiber assay

Xiao-lei Li, Jun-yan Liu, Rong Lu, Qiong Xu, Zhi-feng Zhu, Li Wang, Chun-lei Zhou, Jing Jia, Zheng Fu, Zhi Yao

PHASE I STUDIES

Optimal modeling for phase I design of a two drug combination—results of a phase I study of cisplatin with 9-nitrocamptothecin

S.-J. Lee, M. Gounder, E. H. Rubin, Jong Ming Li, Zheming Gu, A. Thalasila, E. Loyer, A. P. Kudelka, C. F. Verschraegen

PHASE I STUDIES

Phase Ι trial of weekly Docetaxel and daily Temozolomide in patients with metastatic disease

I. Tamaskar, T. Mekhail, R. Dreicer, T. Olencki, S. Roman, P. Elson, R. M. Bukowski

PHASE II STUDIES

O-Mel-Inib: A Cancéro-pôle Nord-Ouest multicenter phase II trial of high-dose Imatinib mesylate in metastatic uveal melanoma

Nicolas Penel, Corinne Delcambre, Xavier Durando, Stéphanie Clisant, Mohamed Hebbar, Sylvie Negrier, Charles Fournier, Nicolas Isambert, Frédéric Mascarelli, Frédéric Mouriaux

PHASE II STUDIES

Effect of oral administration of kefir on serum proinflammatory cytokines on 5-FU induced oral mucositis in patients with colorectal cancer

E. Topuz, D. Derin, G. Can, E. Kürklü, S. Çınar, F. Aykan, A. Çevikbaş, R. Dişçi, Z. Durna, B. Şakar, S. Saglam, H. Tanyeri, G. Deniz, Ü. Gürer, F. Taş, N. Guney, A. Aydıner

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