Investigational New Drugs

Investigational New Drugs OnlineFirst articles

20.08.2019 | PRECLINICAL STUDIES

Benzothiazole derivative bearing amide moiety induces p53-mediated apoptosis in HPV16 positive cervical cancer cells

In our previous study, we screened the anti-cancer properties of 10 benzothiazole derivatives in cervical cancer cell lines. In the present study, we aimed to delineate the mechanism of the apoptotic pathway (whether intrinsic or extrinsic) …

19.08.2019 | PHASE II STUDIES

Prospective, randomized, cross-over pilot study of the effects of Rikkunshito, a Japanese traditional herbal medicine, on anorexia and plasma-acylated ghrelin levels in lung cancer patients undergoing cisplatin-based chemotherapy

Purpose Anorexia induced by cytotoxic chemotherapy on delayed phase is a highly frequent adverse event. We aimed to determine the effects of rikkunshito (RKT) on chemotherapy-induced anorexia (CIA) in patients with lung cancer. Methods This …

14.08.2019 | PRECLINICAL STUDIES

Discovery of a novel rhein-SAHA hybrid as a multi-targeted anti-glioblastoma drug

Glioblastoma multiforme (GBM) is the most common malignant tumor of the central nervous system (CNS). Effective treatments remain limited. Therefore, novel chemotherapy drugs with high efficiency and few adverse effects are urgently needed.

14.08.2019 | PRECLINICAL STUDIES

Identification of HGF as a novel target of miR-15a/16/195 in gastric cancer

Background Gastric malignancy is the third most frequently encountered cancer globally and have been documented to confer extremely poor prognosis, given their limited treatment options. The up-regulation of hepatocyte growth factor (HGF) has been …

11.08.2019 | PHASE II STUDIES

Germinal Immunogenetics predict treatment outcome for PD-1/PD-L1 checkpoint inhibitors

Background Checkpoint inhibitors bring marked benefits but only in a minority of patients and may also be associated with severe adverse events. Treatment outcome still cannot be faithfully predicted. The following study hypothesized that host …