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Cancer and Metastasis Reviews
Erschienen in: Cancer and Metastasis Reviews 3/2017

23.08.2017

Involvement of aberrantly expressed microRNAs in the pathogenesis of head and neck squamous cell carcinoma

verfasst von: Keiichi Koshizuka, Toyoyuki Hanazawa, Takayuki Arai, Atsushi Okato, Naoko Kikkawa, Naohiko Seki

Erschienen in: Cancer and Metastasis Reviews | Ausgabe 3/2017

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Abstract

MicroRNAs (miRNAs) are small noncoding RNAs that act as fine-tuners of the post-transcriptional control of protein-coding or noncoding RNAs by repressing translation or cleaving RNA transcripts in a sequence-dependent manner in cells. Accumulating evidence have been indicated that aberrantly expressed miRNAs are deeply involved in human pathogenesis, including cancers. Surprisingly, these small, single-stranded RNAs (18–23 nucleotides) have been shown to function as antitumor or oncogenic RNAs in several types of cancer cells. A single miRNA has regulating hundreds or thousands of different mRNAs, and individual mRNA has been regulated by multiple different miRNAs in normal cells. Therefore, tightly controlled RNA networks can be disrupted by dysregulated of miRNAs in cancer cells. Investigation of novel miRNA-mediated RNA networks in cancer cells could provide new insights in the field of cancer research. In this review, we focus on head and neck squamous cell carcinoma (HNSCC) and discuss current findings of the involvement of aberrantly expressed miRNAs in the pathogenesis of HNSCC.
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Metadaten
Titel
Involvement of aberrantly expressed microRNAs in the pathogenesis of head and neck squamous cell carcinoma
verfasst von
Keiichi Koshizuka
Toyoyuki Hanazawa
Takayuki Arai
Atsushi Okato
Naoko Kikkawa
Naohiko Seki
Publikationsdatum
23.08.2017
Verlag
Springer US
Erschienen in
Cancer and Metastasis Reviews / Ausgabe 3/2017
Print ISSN: 0167-7659
Elektronische ISSN: 1573-7233
DOI
https://doi.org/10.1007/s10555-017-9692-y

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