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Erschienen in: Clinical and Translational Oncology 6/2015

01.06.2015 | Research Article

Involvement of RalB in the effect of geranylgeranyltransferase I on glioma cell migration and invasion

verfasst von: X. Song, L. Hua, Y. Xu, Z. Fang, Y. Wang, J. Gao, Q. Shi, X. Zhou, R. Yu

Erschienen in: Clinical and Translational Oncology | Ausgabe 6/2015

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Abstract

Purpose

The present study aimed at investigating the role and potential mechanism of geranylgeranyltransferase I (GGTase-I) on glioma cell migration and invasion.

Methods

Wound-healing assay and transwell assay were performed to study whether GGTase-I and Ras-like GTPase B (RalB) have effect on glioma cell migration and invasion.

Results

We found that knockdown of GGTase-I or RalB both significantly decreased the migratory and invasive abilities of glioma cells. GGTase-I down-regulation suppressed RalB membrane association. Moreover, down-regulation of RalB partially abolished the effect of GGTβ over-expression-induced glioma cell migration and invasion increase.

Conclusions

These findings suggest that RalB might be one of the targets for facilitating the invasive phenotype of malignant gliomas induced by GGTase-I.
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Metadaten
Titel
Involvement of RalB in the effect of geranylgeranyltransferase I on glioma cell migration and invasion
verfasst von
X. Song
L. Hua
Y. Xu
Z. Fang
Y. Wang
J. Gao
Q. Shi
X. Zhou
R. Yu
Publikationsdatum
01.06.2015
Verlag
Springer Milan
Erschienen in
Clinical and Translational Oncology / Ausgabe 6/2015
Print ISSN: 1699-048X
Elektronische ISSN: 1699-3055
DOI
https://doi.org/10.1007/s12094-014-1263-x

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