Erschienen in:
01.06.2015 | Research Article
Involvement of RalB in the effect of geranylgeranyltransferase I on glioma cell migration and invasion
verfasst von:
X. Song, L. Hua, Y. Xu, Z. Fang, Y. Wang, J. Gao, Q. Shi, X. Zhou, R. Yu
Erschienen in:
Clinical and Translational Oncology
|
Ausgabe 6/2015
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Abstract
Purpose
The present study aimed at investigating the role and potential mechanism of geranylgeranyltransferase I (GGTase-I) on glioma cell migration and invasion.
Methods
Wound-healing assay and transwell assay were performed to study whether GGTase-I and Ras-like GTPase B (RalB) have effect on glioma cell migration and invasion.
Results
We found that knockdown of GGTase-I or RalB both significantly decreased the migratory and invasive abilities of glioma cells. GGTase-I down-regulation suppressed RalB membrane association. Moreover, down-regulation of RalB partially abolished the effect of GGTβ over-expression-induced glioma cell migration and invasion increase.
Conclusions
These findings suggest that RalB might be one of the targets for facilitating the invasive phenotype of malignant gliomas induced by GGTase-I.