Skip to main content
main-content

12.09.2019 | Glaucoma

Iris lens distance to predict the risk of intraocular pressure elevation after dark room provocative test

Zeitschrift:
Graefe's Archive for Clinical and Experimental Ophthalmology
Autoren:
Xiaoli Liu, Yang Zhang, Lue Li, Ailing Bian, Qi Zhou
Wichtige Hinweise

Publisher’s note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Abstract

Purpose

To investigate if a new ultrasound biomicroscopy (UBM) parameter, iris lens distance (ILD), and its model could predict clinically significant intraocular pressure (IOP) elevation after darkroom provocative test (DRPT).

Methods

Cases with a peripheral anterior chamber depth less than one-fourth corneal thickness were enrolled. All subjects underwent UBM examination and DRPT if possible. Anterior chamber depth (ACD) and ILD were measured in the central axis at different positions in dark (ACDD, ILDD) and bright (ACDB, ILDB). An IOP elevation over 5 mmHg and 8 mmHg was set as cutoffs for a positive DRPT result (positive-5 and positive-8). SAS 9.3 statistical software was used to manage and analyze data and calculate the linear probability model (LPM). Another 17 patients (34 eyes) were included to validate the model.

Results

Two hundred and ten (210) UBM images qualified for analysis. ILD was significantly less in the dark than in the bright and in patients with a positive DRPT result (p < 0.001). The LPM for positive-5 and positive-8 were P = 1.14 + (− 0.49*ILDD) + (− 0.41*ACDD) (n = 210, R2 = 0.1079, AUC = 0.715), and P = 0.87 + (− 0.44*ILDD) + (− 0.35*ACDD) (n = 210, R2 = 0.1358, AUC = 0.807), respectively.

Conclusions

LPMs based on ILD could predict the risk of an IOP elevation over 5 mmHg or 8 mmHg. The LPM for positive-8 reached a good level of diagnostic accuracy.

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

★ PREMIUM-INHALT
e.Med Interdisziplinär

Mit e.Med Interdisziplinär erhalten Sie Zugang zu allen CME-Fortbildungen und Fachzeitschriften auf SpringerMedizin.de. Zusätzlich können Sie eine Zeitschrift Ihrer Wahl in gedruckter Form beziehen – ohne Aufpreis.

Literatur
Über diesen Artikel

Neu im Fachgebiet Augenheilkunde

06.08.2019 | Leitthema | Ausgabe 9/2019

Forschungs- und Entwicklungsbedarf in der Augenheilkunde („Unmet needs“)

Ein konsensbasierter Fahrplan des European Vision Institute (EVI) für die Jahre 2019 bis 2025

01.08.2019 | Erkrankungen der Hornhaut | CME | Ausgabe 8/2019

Neurotrophe Keratopathie

Grundlagen, Diagnostik und Therapie

22.07.2019 | DFP-Fortbildung | Ausgabe 4/2019 Open Access

Aktuelle Möglichkeiten der visuellen Rehabilitation