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Erschienen in: The journal of nutrition, health & aging 3/2017

31.05.2016

Irisin levels are not associated to resistance training-induced alterations in body mass composition in older untrained women with and without obesity

verfasst von: R. A. Tibana, D. da Cunha Nascimento, N. M. Frade de Souza, V. C. de Souza, I. V. de Sousa Neto, F. A. Voltarelli, Guilherme B. Pereira, J. W. Navalta, J. Prestes

Erschienen in: The journal of nutrition, health & aging | Ausgabe 3/2017

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Abstract

Objective

The present study aimed to determine whether Irisin levels are correlated with body composition changes following 16 weeks of resistance training (RT) in older women with and without obesity.

Design, Setting, Participants, Intervention

We recruited 49 inactive women (n = 23, non-obese: < 41.0% and n = 26, obese: ≥ 41.0% of body fat) aged 61–68 years to perform 16-week of RT consisting of 10 exercises (three sets of 10 exercises, 6-12 repetitions maximum and 1-min and 30-s rest intervals between sets and exercises, respectively) with two sessions per week.

Measurements

Before and after the intervention period, blood samples were collected to determine Irisin levels and body composition (percentage body fat and fat-free mass) was measured by dual energy x-ray absorptiometry.

Results

Circulating Irisin displayed a decrease for the non-obese group as compared with pre-intervention and obese group (p = 0.01 and p = 0.04, respectively), with no change for the obese group (p = 0.79). In addition, fat mass displayed a significant reduction (p < 0.05) following the training period only for the obese group. Furthermore, there was no association between changes in circulating Irisin with body mass index, body fat, fat-free mass and muscle strength. There was an increase in muscle strength (p < 0.05), regardless of obesity status.

Conclusion

The modulation of body composition and muscle strength induced by 16-week of resistance training in older women with and without obesity is not associated with changes in circulating Irisin levels.
Literatur
1.
Zurück zum Zitat American College of Sports M. American College of Sports Medicine position stand. Progression models in resistance training for healthy adults. Med Sci Sports Exerc 2009; 41: 687–708 American College of Sports M. American College of Sports Medicine position stand. Progression models in resistance training for healthy adults. Med Sci Sports Exerc 2009; 41: 687–708
2.
Zurück zum Zitat Aydin S. Three new players in energy regulation: preptin, adropin and irisin. Peptides 2014; 56: 94–110CrossRefPubMed Aydin S. Three new players in energy regulation: preptin, adropin and irisin. Peptides 2014; 56: 94–110CrossRefPubMed
3.
Zurück zum Zitat Bassett DR, Jr. International physical activity questionnaire: 12-country reliability and validity. Med Sci Sports Exerc 2003; 35: 1396CrossRefPubMed Bassett DR, Jr. International physical activity questionnaire: 12-country reliability and validity. Med Sci Sports Exerc 2003; 35: 1396CrossRefPubMed
4.
Zurück zum Zitat Bostrom P, Wu J, Jedrychowski MP, Korde A, Ye L, Lo JC, Rasbach KA, Bostrom EA, Choi JH, Long JZ, Kajimura S, Zingaretti MC, Vind BF, Tu H, Cinti S, Hojlund K, Gygi SP, Spiegelman BM. A PGC1-alpha-dependent myokine that drives brownfat-like development of white fat and thermogenesis. Nature 2012; 481: 463–468CrossRefPubMedPubMedCentral Bostrom P, Wu J, Jedrychowski MP, Korde A, Ye L, Lo JC, Rasbach KA, Bostrom EA, Choi JH, Long JZ, Kajimura S, Zingaretti MC, Vind BF, Tu H, Cinti S, Hojlund K, Gygi SP, Spiegelman BM. A PGC1-alpha-dependent myokine that drives brownfat-like development of white fat and thermogenesis. Nature 2012; 481: 463–468CrossRefPubMedPubMedCentral
5.
Zurück zum Zitat Botero JP, Shiguemoto GE, Prestes J, Marin CT, Do Prado WL, Pontes CS, Guerra RL, Ferreia FC, Baldissera V, Perez SE. Effects of long-term periodized resistance training on body composition, leptin, resistin and muscle strength in elderly postmenopausal women. J Sports Med Phys Fitness 2013; 53: 289–294PubMed Botero JP, Shiguemoto GE, Prestes J, Marin CT, Do Prado WL, Pontes CS, Guerra RL, Ferreia FC, Baldissera V, Perez SE. Effects of long-term periodized resistance training on body composition, leptin, resistin and muscle strength in elderly postmenopausal women. J Sports Med Phys Fitness 2013; 53: 289–294PubMed
6.
Zurück zum Zitat Cruz-Jentoft AJ, Baeyens JP, Bauer JM, Boirie Y, Cederholm T, Landi F, Martin FC, Michel JP, Rolland Y, Schneider SM, Topinkova E, Vandewoude M, Zamboni M, European Working Group on Sarcopenia in Older P. Sarcopenia: European consensus on definition and diagnosis: Report of the European Working Group on Sarcopenia in Older People. Age Ageing 2010; 39: 412–423CrossRefPubMedPubMedCentral Cruz-Jentoft AJ, Baeyens JP, Bauer JM, Boirie Y, Cederholm T, Landi F, Martin FC, Michel JP, Rolland Y, Schneider SM, Topinkova E, Vandewoude M, Zamboni M, European Working Group on Sarcopenia in Older P. Sarcopenia: European consensus on definition and diagnosis: Report of the European Working Group on Sarcopenia in Older People. Age Ageing 2010; 39: 412–423CrossRefPubMedPubMedCentral
7.
Zurück zum Zitat Ellefsen S, Vikmoen O, Slettalokken G, Whist JE, Nygaard H, Hollan I, Rauk I, Vegge G, Strand TA, Raastad T, Ronnestad BR. Irisin and FNDC5: effects of 12-week strength training, and relations to muscle phenotype and body mass composition in untrained women. Eur J Appl Physiol 2014; 114: 1875–1888CrossRefPubMed Ellefsen S, Vikmoen O, Slettalokken G, Whist JE, Nygaard H, Hollan I, Rauk I, Vegge G, Strand TA, Raastad T, Ronnestad BR. Irisin and FNDC5: effects of 12-week strength training, and relations to muscle phenotype and body mass composition in untrained women. Eur J Appl Physiol 2014; 114: 1875–1888CrossRefPubMed
8.
Zurück zum Zitat Faul F, Erdfelder E, Lang AG, Buchner A. G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav Res Methods 2007; 39: 175–191CrossRefPubMed Faul F, Erdfelder E, Lang AG, Buchner A. G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav Res Methods 2007; 39: 175–191CrossRefPubMed
9.
Zurück zum Zitat Gallagher D, Heymsfield SB, Heo M, Jebb SA, Murgatroyd PR, Sakamoto Y. Healthy percentage body fat ranges: an approach for developing guidelines based on body mass index. Am J Clin Nutr 2000; 72: 694–701PubMed Gallagher D, Heymsfield SB, Heo M, Jebb SA, Murgatroyd PR, Sakamoto Y. Healthy percentage body fat ranges: an approach for developing guidelines based on body mass index. Am J Clin Nutr 2000; 72: 694–701PubMed
10.
Zurück zum Zitat Hallal PC, Gomez LF, Parra DC, Lobelo F, Mosquera J, Florindo AA, Reis RS, Pratt M, Sarmiento OL. Lessons learned after 10 years of IPAQ use in Brazil and Colombia. J Phys Act Health 2010; 7 Suppl 2: S259–264CrossRefPubMed Hallal PC, Gomez LF, Parra DC, Lobelo F, Mosquera J, Florindo AA, Reis RS, Pratt M, Sarmiento OL. Lessons learned after 10 years of IPAQ use in Brazil and Colombia. J Phys Act Health 2010; 7 Suppl 2: S259–264CrossRefPubMed
11.
Zurück zum Zitat Hayashida I, Tanimoto Y, Takahashi Y, Kusabiraki T, Tamaki J. Correlation between muscle strength and muscle mass, and their association with walking speed, in community-dwelling elderly Japanese individuals. PLoS One 2014; 9: e111810CrossRefPubMedPubMedCentral Hayashida I, Tanimoto Y, Takahashi Y, Kusabiraki T, Tamaki J. Correlation between muscle strength and muscle mass, and their association with walking speed, in community-dwelling elderly Japanese individuals. PLoS One 2014; 9: e111810CrossRefPubMedPubMedCentral
12.
Zurück zum Zitat Hecksteden A, Wegmann M, Steffen A, Kraushaar J, Morsch A, Ruppenthal S, Kaestner L, Meyer T. Irisin and exercise training in humans-results from a randomized controlled training trial. BMC Med 2013; 11: 235CrossRefPubMedPubMedCentral Hecksteden A, Wegmann M, Steffen A, Kraushaar J, Morsch A, Ruppenthal S, Kaestner L, Meyer T. Irisin and exercise training in humans-results from a randomized controlled training trial. BMC Med 2013; 11: 235CrossRefPubMedPubMedCentral
13.
Zurück zum Zitat Hofmann T, Elbelt U, Stengel A. Irisin as a muscle-derived hormone stimulating thermogenesis—a critical update. Peptides 2014; 54: 89–100CrossRefPubMed Hofmann T, Elbelt U, Stengel A. Irisin as a muscle-derived hormone stimulating thermogenesis—a critical update. Peptides 2014; 54: 89–100CrossRefPubMed
14.
Zurück zum Zitat Huh JY, Mougios V, Kabasakalis A, Fatouros I, Siopi A, Douroudos, II, Filippaios A, Panagiotou G, Park KH, Mantzoros CS. Exercise-induced irisin secretion is independent of age or fitness level and increased irisin may directly modulate muscle metabolism through AMPK activation. J Clin Endocrinol Metab 2014; 99: E2154–2161CrossRefPubMed Huh JY, Mougios V, Kabasakalis A, Fatouros I, Siopi A, Douroudos, II, Filippaios A, Panagiotou G, Park KH, Mantzoros CS. Exercise-induced irisin secretion is independent of age or fitness level and increased irisin may directly modulate muscle metabolism through AMPK activation. J Clin Endocrinol Metab 2014; 99: E2154–2161CrossRefPubMed
15.
Zurück zum Zitat Huh JY, Panagiotou G, Mougios V, Brinkoetter M, Vamvini MT, Schneider BE, Mantzoros CS. FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise. Metabolism 2012; 61: 1725–1738PubMed Huh JY, Panagiotou G, Mougios V, Brinkoetter M, Vamvini MT, Schneider BE, Mantzoros CS. FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise. Metabolism 2012; 61: 1725–1738PubMed
16.
Zurück zum Zitat Huh JY, Siopi A, Mougios V, Park KH, Mantzoros CS. Irisin in response to exercise in humans with and without metabolic syndrome. J Clin Endocrinol Metab 2015; 100: E453–457CrossRefPubMed Huh JY, Siopi A, Mougios V, Park KH, Mantzoros CS. Irisin in response to exercise in humans with and without metabolic syndrome. J Clin Endocrinol Metab 2015; 100: E453–457CrossRefPubMed
17.
18.
Zurück zum Zitat Janssen I, Heymsfield SB, Ross R. Low relative skeletal muscle mass (sarcopenia) in older persons is associated with functional impairment and physical disability. J Am Geriatr Soc 2002; 50: 889–896CrossRefPubMed Janssen I, Heymsfield SB, Ross R. Low relative skeletal muscle mass (sarcopenia) in older persons is associated with functional impairment and physical disability. J Am Geriatr Soc 2002; 50: 889–896CrossRefPubMed
19.
Zurück zum Zitat Kraemer RR, Shockett P, Webb ND, Shah U, Castracane VD. A transient elevated irisin blood concentration in response to prolonged, moderate aerobic exercise in young men and women. Horm Metab Res 2014; 46: 150–154PubMed Kraemer RR, Shockett P, Webb ND, Shah U, Castracane VD. A transient elevated irisin blood concentration in response to prolonged, moderate aerobic exercise in young men and women. Horm Metab Res 2014; 46: 150–154PubMed
20.
Zurück zum Zitat Kurdiova T, Balaz M, Vician M, Maderova D, Vlcek M, Valkovic L, Srbecky M, Imrich R, Kyselovicova O, Belan V, Jelok I, Wolfrum C, Klimes I, Krssak M, Zemkova E, Gasperikova D, Ukropec J, Ukropcova B. Effects of obesity, diabetes and exercise on Fndc5 gene expression and irisin release in human skeletal muscle and adipose tissue: in vivo and in vitro studies. J Physiol 2014; 592: 1091–1107CrossRefPubMedPubMedCentral Kurdiova T, Balaz M, Vician M, Maderova D, Vlcek M, Valkovic L, Srbecky M, Imrich R, Kyselovicova O, Belan V, Jelok I, Wolfrum C, Klimes I, Krssak M, Zemkova E, Gasperikova D, Ukropec J, Ukropcova B. Effects of obesity, diabetes and exercise on Fndc5 gene expression and irisin release in human skeletal muscle and adipose tissue: in vivo and in vitro studies. J Physiol 2014; 592: 1091–1107CrossRefPubMedPubMedCentral
21.
Zurück zum Zitat Norheim F, Langleite TM, Hjorth M, Holen T, Kielland A, Stadheim HK, Gulseth HL, Birkeland KI, Jensen J, Drevon CA. The effects of acute and chronic exercise on PGC-1alpha, irisin and browning of subcutaneous adipose tissue in humans. FEBS J 2014; 281: 739–749CrossRefPubMed Norheim F, Langleite TM, Hjorth M, Holen T, Kielland A, Stadheim HK, Gulseth HL, Birkeland KI, Jensen J, Drevon CA. The effects of acute and chronic exercise on PGC-1alpha, irisin and browning of subcutaneous adipose tissue in humans. FEBS J 2014; 281: 739–749CrossRefPubMed
22.
Zurück zum Zitat Pedersen BK. Exercise-induced myokines and their role in chronic diseases. Brain Behav Immun 2011; 25: 811–816CrossRefPubMed Pedersen BK. Exercise-induced myokines and their role in chronic diseases. Brain Behav Immun 2011; 25: 811–816CrossRefPubMed
23.
Zurück zum Zitat Pedersen BK, Akerstrom TC, Nielsen AR, Fischer CP. Role of myokines in exercise and metabolism. J Appl Physiol (1985) 2007; 103: 1093–1098CrossRef Pedersen BK, Akerstrom TC, Nielsen AR, Fischer CP. Role of myokines in exercise and metabolism. J Appl Physiol (1985) 2007; 103: 1093–1098CrossRef
24.
Zurück zum Zitat Peterson MD, Gordon PM. Resistance exercise for the aging adult: clinical implications and prescription guidelines. Am J Med 2011; 124: 194–198CrossRefPubMed Peterson MD, Gordon PM. Resistance exercise for the aging adult: clinical implications and prescription guidelines. Am J Med 2011; 124: 194–198CrossRefPubMed
25.
Zurück zum Zitat Phillips MD, Patrizi RM, Cheek DJ, Wooten JS, Barbee JJ, Mitchell JB. Resistance training reduces subclinical inflammation in obese, postmenopausal women. Med Sci Sports Exerc 2012; 44: 2099–2110CrossRefPubMed Phillips MD, Patrizi RM, Cheek DJ, Wooten JS, Barbee JJ, Mitchell JB. Resistance training reduces subclinical inflammation in obese, postmenopausal women. Med Sci Sports Exerc 2012; 44: 2099–2110CrossRefPubMed
26.
Zurück zum Zitat Prestes J, Shiguemoto G, Botero JP, Frollini A, Dias R, Leite R, Pereira G, Magosso R, Baldissera V, Cavaglieri C, Perez S. Effects of resistance training on resistin, leptin, cytokines, and muscle force in elderly post-menopausal women. J Sports Sci 2009; 27: 1607–1615CrossRefPubMed Prestes J, Shiguemoto G, Botero JP, Frollini A, Dias R, Leite R, Pereira G, Magosso R, Baldissera V, Cavaglieri C, Perez S. Effects of resistance training on resistin, leptin, cytokines, and muscle force in elderly post-menopausal women. J Sports Sci 2009; 27: 1607–1615CrossRefPubMed
27.
Zurück zum Zitat Scharhag-Rosenberger F, Meyer T, Wegmann M, Ruppenthal S, Kaestner L, Morsch A, Hecksteden A. Irisin does not mediate resistance training-induced alterations in resting metabolic rate. Med Sci Sports Exerc 2014; 46: 1736–1743CrossRefPubMed Scharhag-Rosenberger F, Meyer T, Wegmann M, Ruppenthal S, Kaestner L, Morsch A, Hecksteden A. Irisin does not mediate resistance training-induced alterations in resting metabolic rate. Med Sci Sports Exerc 2014; 46: 1736–1743CrossRefPubMed
28.
Zurück zum Zitat Silva AO, Karnikowski MG, Funghetto SS, Stival MM, Lima RM, de Souza JC, Navalta JW, Prestes J. Association of body composition with sarcopenic obesity in elderly women. Int J Gen Med 2013; 6: 25–29CrossRefPubMedPubMedCentral Silva AO, Karnikowski MG, Funghetto SS, Stival MM, Lima RM, de Souza JC, Navalta JW, Prestes J. Association of body composition with sarcopenic obesity in elderly women. Int J Gen Med 2013; 6: 25–29CrossRefPubMedPubMedCentral
29.
Zurück zum Zitat Smee D, Pumpa K, Falchi M, Lithander FE. The Relationship between Diet Quality and Falls Risk, Physical Function and Body Composition in Older Adults. J Nutr Health Aging 2015; 19: 1037–1042CrossRefPubMed Smee D, Pumpa K, Falchi M, Lithander FE. The Relationship between Diet Quality and Falls Risk, Physical Function and Body Composition in Older Adults. J Nutr Health Aging 2015; 19: 1037–1042CrossRefPubMed
30.
Zurück zum Zitat Soares-Caldeira LF, Ritti-Dias RM, Okuno NM, Cyrino ES, Gurjao AL, Ploutz-Snyder LL. Familiarization indexes in sessions of 1-RM tests in adult women. J Strength Cond Res 2009; 23: 2039–2045CrossRefPubMed Soares-Caldeira LF, Ritti-Dias RM, Okuno NM, Cyrino ES, Gurjao AL, Ploutz-Snyder LL. Familiarization indexes in sessions of 1-RM tests in adult women. J Strength Cond Res 2009; 23: 2039–2045CrossRefPubMed
31.
Zurück zum Zitat Tibana RA, Nascimento Dda C, de Sousa NM, de Souza VC, Durigan J, Vieira A, Bottaro M, Nobrega Ode T, de Almeida JA, Navalta JW, Franco OL, Prestes J. Enhancing of women functional status with metabolic syndrome by cardioprotective and anti-inflammatory effects of combined aerobic and resistance training. PLoS One 2014; 9: e110160CrossRefPubMed Tibana RA, Nascimento Dda C, de Sousa NM, de Souza VC, Durigan J, Vieira A, Bottaro M, Nobrega Ode T, de Almeida JA, Navalta JW, Franco OL, Prestes J. Enhancing of women functional status with metabolic syndrome by cardioprotective and anti-inflammatory effects of combined aerobic and resistance training. PLoS One 2014; 9: e110160CrossRefPubMed
32.
Zurück zum Zitat Visser M, Goodpaster BH, Kritchevsky SB, Newman AB, Nevitt M, Rubin SM, Simonsick EM, Harris TB. Muscle mass, muscle strength, and muscle fat infiltration as predictors of incident mobility limitations in well-functioning older persons. J Gerontol A Biol Sci Med Sci 2005; 60: 324–333CrossRefPubMed Visser M, Goodpaster BH, Kritchevsky SB, Newman AB, Nevitt M, Rubin SM, Simonsick EM, Harris TB. Muscle mass, muscle strength, and muscle fat infiltration as predictors of incident mobility limitations in well-functioning older persons. J Gerontol A Biol Sci Med Sci 2005; 60: 324–333CrossRefPubMed
33.
Zurück zum Zitat Zamboni M, Mazzali G, Fantin F, Rossi A, Di Francesco V. Sarcopenic obesity: a new category of obesity in the elderly. Nutr Metab Cardiovasc Dis 2008; 18: 388–395CrossRefPubMed Zamboni M, Mazzali G, Fantin F, Rossi A, Di Francesco V. Sarcopenic obesity: a new category of obesity in the elderly. Nutr Metab Cardiovasc Dis 2008; 18: 388–395CrossRefPubMed
Metadaten
Titel
Irisin levels are not associated to resistance training-induced alterations in body mass composition in older untrained women with and without obesity
verfasst von
R. A. Tibana
D. da Cunha Nascimento
N. M. Frade de Souza
V. C. de Souza
I. V. de Sousa Neto
F. A. Voltarelli
Guilherme B. Pereira
J. W. Navalta
J. Prestes
Publikationsdatum
31.05.2016
Verlag
Springer Paris
Erschienen in
The journal of nutrition, health & aging / Ausgabe 3/2017
Print ISSN: 1279-7707
Elektronische ISSN: 1760-4788
DOI
https://doi.org/10.1007/s12603-016-0748-4

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