Erschienen in:
05.12.2017 | Progress in Hematology
Iron metabolism and related diseases: an overview
verfasst von:
Hideo Harigae
Erschienen in:
International Journal of Hematology
|
Ausgabe 1/2018
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Excerpt
Iron is an essential metal not only for oxygen delivery but also for cellular processes, including ATP production and DNA biosynthesis. Iron is utilized by the semi-closed system and is not actively excreted from the body. This system is advantageous, because it prevents the shortage of this important metal and is not influenced by the environmental status. In this system, the iron supply depends on a narrow gate at the duodenum, and iron accumulates in the organ once it is overloaded. These specificities of iron metabolism lead to the high frequency of iron deficiency anemia (IDA) among young females and secondary hemochromatosis due to blood transfusion. …