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Erschienen in: International Journal of Hematology 3/2019

03.01.2019 | Images in Hematology

Is clinicopathological distinction of mucosa-associated lymphoid tissue lymphoma from Waldenström macroglobulinemia essential in MYD88 L265P mutation-positive cases?

verfasst von: Keisuke Kidoguchi, Kensuke Kojima, Ritsuko Seki, Koji Nagafuji, Koichi Ohshima, Shinya Kimura

Erschienen in: International Journal of Hematology | Ausgabe 3/2019

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Excerpt

A 54-year-old man underwent liver segmentectomy for a solitary MALT lymphoma (4 cm in the longest diameter) found during his annual medical checkup (Fig. 1a, b). He was seronegative for hepatitis B surface antigen and antibodies against hepatitis C. Four years later, he developed Waldenström macroglobulinemia in the absence of tumorous lesions (Fig. 1c, d). MYD88 L265P mutation was detected in formalin-fixed and paraffin-embedded liver tumor tissue and bone marrow biopsy specimen. The clinicopathological transition indicates that MYD88 L265P mutation, a diagnostic biomarker for WM/LPL, does not always differentiate WM/LPL from other B-cell disorders. Whether patients with this mutation benefit from BTK inhibitor treatment irrespective of histopathological diagnosis is a clinically important question. …
Metadaten
Titel
Is clinicopathological distinction of mucosa-associated lymphoid tissue lymphoma from Waldenström macroglobulinemia essential in MYD88 L265P mutation-positive cases?
verfasst von
Keisuke Kidoguchi
Kensuke Kojima
Ritsuko Seki
Koji Nagafuji
Koichi Ohshima
Shinya Kimura
Publikationsdatum
03.01.2019
Verlag
Springer Japan
Erschienen in
International Journal of Hematology / Ausgabe 3/2019
Print ISSN: 0925-5710
Elektronische ISSN: 1865-3774
DOI
https://doi.org/10.1007/s12185-018-02585-8

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