Skip to main content
main-content

21.01.2017 | Bone and Diabetes (A Schwartz and P Vestergaard, section editors) | Ausgabe 1/2017

Current Osteoporosis Reports 1/2017

Is Diabetic Skeletal Fragility Associated with Microvascular Complications in Bone?

Zeitschrift:
Current Osteoporosis Reports > Ausgabe 1/2017
Autor:
Roberto Jose Fajardo
Wichtige Hinweise
This article is part of the Topical Collection on Bone and Diabetes

Abstract

Purpose of Review

The objective of this literature review is to determine whether there are indications that microvascular complications occur in diabetic bone. Evidence definitively linking diabetic skeletal fragility with microvascular complications in bone remains elusive.

Recent Findings

Circumstantial evidence, some recent and some lost to time, suggests that atherosclerotic vascular diseases such as peripheral arterial disease cause poor blood perfusion of bone and subsequent hypoxia and contribute to low bone density and high cortical porosity, patterns similar to some recently observed in diabetic subjects. Evidence also exists to suggest that potentially anti-angiogenic conditions, such as impaired vascular endothelial growth factor (VEGF) signaling, predominate in diabetic bone.

Summary

Microvascular complications may contribute, in part, to diabetic skeletal fragility but data supporting this interpretation are primarily circumstantial at this time. This review highlights gaps in our knowledge and hopefully spurs further discussions and research on this topic.

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

★ PREMIUM-INHALT
e.Med Interdisziplinär

Mit e.Med Interdisziplinär erhalten Sie Zugang zu allen CME-Fortbildungen und Fachzeitschriften auf SpringerMedizin.de. Zusätzlich können Sie eine Zeitschrift Ihrer Wahl in gedruckter Form beziehen – ohne Aufpreis.

Literatur
Über diesen Artikel

Weitere Artikel der Ausgabe 1/2017

Current Osteoporosis Reports 1/2017 Zur Ausgabe

Kidney and Bone (S Moe and I Salusky, Section Editors)

The Role of TGFβ in Bone-Muscle Crosstalk

Biomechanics (M Silva and K Jepsen, Section Editors)

Clinical Evaluation of Bone Strength and Fracture Risk

Skeletal Development (P Trainor and K Svoboda, Section Editors)

Connexin43 and the Intercellular Signaling Network Regulating Skeletal Remodeling

Craniofacial Skeleton (G Roberts, Section Editor)

Genetic Disorders of Dental Development: Tales from the Bony Crypt

Neu im Fachgebiet Orthopädie und Unfallchirurgie

Mail Icon II Newsletter

Bestellen Sie unseren kostenlosen Newsletter Update Orthopädie und Unfallchirurgie und bleiben Sie gut informiert – ganz bequem per eMail.

Bildnachweise