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Erschienen in: The journal of nutrition, health & aging 2/2019

27.10.2018

Is Fat Mass Cross-Sectionally Associated with Cortical Aβ Load in the Human Brain?

verfasst von: Mathieu Maltais, P. de Souto Barreto, Y. Rolland, B. Vellas, MAPT/DSA Study Group

Erschienen in: The journal of nutrition, health & aging | Ausgabe 2/2019

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Abstract

Objectives

The objective of this study was to examine the relationship of fat mass (FM) with brain amyloid (Aβ) load in older adults.

Methods

Data from the Multidomain Alzheimer’s Preventive Trial (MAPT) for Positron emission tomography and dual-energy X-ray absorptiometry (DXA) were used. Linear regressions controlling for appendicular muscle, age, education, clinical dementia rating scale and Apolipoprotein-E were performed to explore the relationships between FM, trunk FM and Aβ-load.

Results

Thirty-nine participants (75.7 ± 4.2 years old) with an average BMI of 27.5 ± 4.0 kg/m2 were analyzed in this study. There were significant and positive associations of both total and trunk FM with Aβ load [0.01 (0.002-0.02) and 0.02 (0.001-0.04), respectively]; however, when adding ApoE-ε4 as a confounder, associations were no longer significant.

Conclusions

This study has found associations between FM as measured by DXA and cerebral Aβ load, suggesting that excessive FM might be involved in AD pathology.
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Metadaten
Titel
Is Fat Mass Cross-Sectionally Associated with Cortical Aβ Load in the Human Brain?
verfasst von
Mathieu Maltais
P. de Souto Barreto
Y. Rolland
B. Vellas
MAPT/DSA Study Group
Publikationsdatum
27.10.2018
Verlag
Springer Paris
Erschienen in
The journal of nutrition, health & aging / Ausgabe 2/2019
Print ISSN: 1279-7707
Elektronische ISSN: 1760-4788
DOI
https://doi.org/10.1007/s12603-018-1121-6

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