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Current Anesthesiology Reports

Erschienen in:

16.06.2020 | Anesthesia for Trauma (TE Grissom, Section Editor)

Is Fresh Frozen Plasma Still Necessary for Management of Acute Traumatic Coagulopathy?

verfasst von: Giles R. Nordmann, Detlef Obal

Erschienen in: Current Anesthesiology Reports | Ausgabe 3/2020

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Abstract

Purpose of Review

Massive blood loss secondary to major trauma is a leading cause of death worldwide. In recent years, multiple different strategies have evolved to counteract this life-threatening condition. In this review, we will review our understanding of trauma-induced coagulopathy and summarize current clinical transfusion regimes utilized in military and civilian settings. We will review currently available blood products used to rectify the coherent disturbances of haemostasis by outlining the characteristics of the different products.

Recent Findings

Current evidence suggests that fresh frozen plasma and fibrinogen components play a fundamental role in trauma resuscitation with recent studies suggesting pre-hospital plasma and fibrinogen administration might also be beneficial in counteracting trauma-induced coagulopathy. Based on experience out of combat zones, whole blood transfusion might experience a renaissance in the future.

Summary

Multiple different plasma-based products are available to treat and prevent trauma-induced coagulation disturbances. As randomized controlled trials in trauma population are difficult to conduct, most of the evidence is currently based on relatively small studies. While the overarching result of our review suggests the early use of plasma and fibrinogen products in combination with packed red blood cells will prevent trauma-induced coagulopathy, large, multi-centre studies are warranted to evaluate the long-term effects on patients’ outcome.

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Titel: Is Fresh Frozen Plasma Still Necessary for Management of Acute Traumatic Coagulopathy?
verfasst von: Giles R. Nordmann
Detlef Obal
Publikationsdatum: 16.06.2020
Verlag: Springer US
Erschienen in: Current Anesthesiology Reports / Ausgabe 3/2020
Elektronische ISSN: 2167-6275
DOI: https://doi.org/10.1007/s40140-020-00397-3

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Springer Medizin

Is Fresh Frozen Plasma Still Necessary for Management of Acute Traumatic Coagulopathy?

Abstract

Purpose of Review

Recent Findings

Summary

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Springer Medizin

Abstract

Purpose of Review

Recent Findings

Summary

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