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Erschienen in: Endocrine 2/2018

02.05.2017 | Research Letter

Is levothyroxine requirement the same for tablet and soft gel formulations?

verfasst von: Vincenzo Di Donna, Rosa Maria Paragliola, Chiara de Waure, Giampaolo Papi, Alfredo Pontecorvi, Salvatore Maria Corsello

Erschienen in: Endocrine | Ausgabe 2/2018

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Excerpt

Synthetic levothyroxine (LT4) sodium is the gold standard for the treatment of hypothyroidism, but finding the individually tailored LT4 dose level is still challenging [1, 2]. …
Literatur
1.
Zurück zum Zitat A.M. Formenti, G. Mazziotti, R. Giubbini, A. Giustina, Treatment of hypothyroidism: all that glitters is gold? Endocrine 52, 411–413 (2016)CrossRefPubMed A.M. Formenti, G. Mazziotti, R. Giubbini, A. Giustina, Treatment of hypothyroidism: all that glitters is gold? Endocrine 52, 411–413 (2016)CrossRefPubMed
2.
Zurück zum Zitat P. Colucci, C. Seng Yue, M. Ducharme, S. Benvenga, A review of the pharmacokinetics of levothyroxine for the treatment of hypothyroidism. Eur. Endocrinol. 9, 40–47 (2013)CrossRef P. Colucci, C. Seng Yue, M. Ducharme, S. Benvenga, A review of the pharmacokinetics of levothyroxine for the treatment of hypothyroidism. Eur. Endocrinol. 9, 40–47 (2013)CrossRef
3.
Zurück zum Zitat R. Vita, P. Fallahi, A. Antonelli, S. Benvenga, The administration of L-thyroxine as soft gel capsule or liquid solution. Expert Opin. Drug Deliv. 11, 1103–1011 (2014)CrossRefPubMed R. Vita, P. Fallahi, A. Antonelli, S. Benvenga, The administration of L-thyroxine as soft gel capsule or liquid solution. Expert Opin. Drug Deliv. 11, 1103–1011 (2014)CrossRefPubMed
4.
Zurück zum Zitat V. Di Donna, M.G. Santoro, C. de Waure, M.P. Ricciato, R.M. Paragliola, A. Pontecorvi, S.M. Corsello, A new strategy to estimate levothyroxine requirement after total thyroidectomy for benign thyroid disease. Thyroid 24, 1759–1764 (2014)CrossRefPubMed V. Di Donna, M.G. Santoro, C. de Waure, M.P. Ricciato, R.M. Paragliola, A. Pontecorvi, S.M. Corsello, A new strategy to estimate levothyroxine requirement after total thyroidectomy for benign thyroid disease. Thyroid 24, 1759–1764 (2014)CrossRefPubMed
5.
Zurück zum Zitat D. Mistry, S. Atkin, H. Atkinson, S. Gunasekaran, D. Sylvester, A.S. Rigby, R.J. England, Predicting thyroxine requirements following total thyroidectomy. Clin. Endocrinol. 74, 384–387 (2011)CrossRef D. Mistry, S. Atkin, H. Atkinson, S. Gunasekaran, D. Sylvester, A.S. Rigby, R.J. England, Predicting thyroxine requirements following total thyroidectomy. Clin. Endocrinol. 74, 384–387 (2011)CrossRef
6.
Zurück zum Zitat F. Santini, A. Pinchera, A. Marsili, G. Ceccarini, M.G. Castagna, R. Valeriano, M. Giannetti, D. Taddei, R. Centoni, G. Scartabelli, T. Rago, C. Mammoli, R. Elisei, P. Vitti, Lean body mass is a major determinant of levothyroxine dosage in the treatment of thyroid disease. J. Clin. Endocrinol. Metab. 90, 124–127 (2005)CrossRefPubMed F. Santini, A. Pinchera, A. Marsili, G. Ceccarini, M.G. Castagna, R. Valeriano, M. Giannetti, D. Taddei, R. Centoni, G. Scartabelli, T. Rago, C. Mammoli, R. Elisei, P. Vitti, Lean body mass is a major determinant of levothyroxine dosage in the treatment of thyroid disease. J. Clin. Endocrinol. Metab. 90, 124–127 (2005)CrossRefPubMed
7.
Zurück zum Zitat C. Virili, P. Trimboli, F. Romanelli, M. Centanni, Liquid and softgel levothyroxine use in clinical practice: state of the art. Endocrine 54, 3–14 (2016)CrossRefPubMed C. Virili, P. Trimboli, F. Romanelli, M. Centanni, Liquid and softgel levothyroxine use in clinical practice: state of the art. Endocrine 54, 3–14 (2016)CrossRefPubMed
8.
Zurück zum Zitat D. Al-Numani, C. Scarsi, M.P. Ducharme, Levothyroxine soft capsules demonstrate bioequivalent pharmacokinetic exposure with the European reference tablets in healthy volunteers under fasting conditions. Int. J. Clin. Pharmacol. Ther. 54, 135–143 (2016)CrossRefPubMed D. Al-Numani, C. Scarsi, M.P. Ducharme, Levothyroxine soft capsules demonstrate bioequivalent pharmacokinetic exposure with the European reference tablets in healthy volunteers under fasting conditions. Int. J. Clin. Pharmacol. Ther. 54, 135–143 (2016)CrossRefPubMed
9.
Zurück zum Zitat R. Vita, G. Saraceno, F. Trimarchi, S. Benvenga, A novel formulation of L-thyroxine (L-T4) reduces the problem of L-T4 malabsorption by coffee observed with traditional tablet formulations. Endocrine 43, 154–160 (2013)CrossRefPubMed R. Vita, G. Saraceno, F. Trimarchi, S. Benvenga, A novel formulation of L-thyroxine (L-T4) reduces the problem of L-T4 malabsorption by coffee observed with traditional tablet formulations. Endocrine 43, 154–160 (2013)CrossRefPubMed
10.
Zurück zum Zitat M.G. Santaguida, C. Virili, S.C. Duca, M. Cellini, I. Gatto, N. Brusca, C. De Vito, L. Gargano, M. Centanni, Thyroxine softgel capsule in patients with gastric-related T4 malabsorption. Endocrine 49, 51–57 (2015)CrossRefPubMed M.G. Santaguida, C. Virili, S.C. Duca, M. Cellini, I. Gatto, N. Brusca, C. De Vito, L. Gargano, M. Centanni, Thyroxine softgel capsule in patients with gastric-related T4 malabsorption. Endocrine 49, 51–57 (2015)CrossRefPubMed
11.
Zurück zum Zitat C. Cappelli, I. Pirola, E. Gandossi, A. Cristiano, L. Daffini, B. Agosti, C. Casella, M. Castellano, Hormone profile in patients ingesting soft gel capsule or liquid levothyroxine formulations with breakfast. Int. J. Endocrinol. (2016). doi:10.1155/2016/9043450 C. Cappelli, I. Pirola, E. Gandossi, A. Cristiano, L. Daffini, B. Agosti, C. Casella, M. Castellano, Hormone profile in patients ingesting soft gel capsule or liquid levothyroxine formulations with breakfast. Int. J. Endocrinol. (2016). doi:10.​1155/​2016/​9043450
12.
Zurück zum Zitat P. Fallahi, S.M. Ferrari, A. Antonelli, Oral L-thyroxine liquid versus tablet in patients with hypothyroidism without malabsorption: a prospective study. Endocrine 52, 597–560 (2016)CrossRefPubMed P. Fallahi, S.M. Ferrari, A. Antonelli, Oral L-thyroxine liquid versus tablet in patients with hypothyroidism without malabsorption: a prospective study. Endocrine 52, 597–560 (2016)CrossRefPubMed
13.
Zurück zum Zitat D. Brancato, A. Scorsone, G. Saura, L. Ferrara, A. Di Noto, V. Aiello, M. Fleres, V. Provenzano, Comparison of TSH levels with liquid formulation versus tablet formulations of levothyroxine in the treatment of adult hypothyroidism. Endocr. Pract. 20, 657–662 (2014)CrossRefPubMed D. Brancato, A. Scorsone, G. Saura, L. Ferrara, A. Di Noto, V. Aiello, M. Fleres, V. Provenzano, Comparison of TSH levels with liquid formulation versus tablet formulations of levothyroxine in the treatment of adult hypothyroidism. Endocr. Pract. 20, 657–662 (2014)CrossRefPubMed
14.
Zurück zum Zitat R. Negro, R. Valcavi, D. Agrimi, K.A. Toulis, Levothyroxine liquid solution versus tablet for replacement treatment in hypothyroid patients. Endocr. Pract. 20, 901–906 (2014)CrossRefPubMed R. Negro, R. Valcavi, D. Agrimi, K.A. Toulis, Levothyroxine liquid solution versus tablet for replacement treatment in hypothyroid patients. Endocr. Pract. 20, 901–906 (2014)CrossRefPubMed
15.
Zurück zum Zitat C.P. Lombardi, R. Bocale, A. Barini, A. Barini, A. D’Amore, M. Boscherini, R. Bellantone, Comparative study between the effects of replacement therapy with liquid and tablet ormulations of levothyroxine on mood states, self-perceived psychological well-being and thyroid hormone profile in recently thyroidectomized patients. Endocrine 55, 51–59 (2016)CrossRefPubMed C.P. Lombardi, R. Bocale, A. Barini, A. Barini, A. D’Amore, M. Boscherini, R. Bellantone, Comparative study between the effects of replacement therapy with liquid and tablet ormulations of levothyroxine on mood states, self-perceived psychological well-being and thyroid hormone profile in recently thyroidectomized patients. Endocrine 55, 51–59 (2016)CrossRefPubMed
16.
Zurück zum Zitat A. Cassio, S. Monti, A. Rizzello, I. Bettocchi, F. Baronio, G. D’Addabbo, M.O. Bal, A. Balsamo, Comparison between liquid and tablet formulations of levothyroxine in the initial treatment of congenital hypothyroidism. J. Pediatr. 162, 1264–1269 (2013)CrossRefPubMed A. Cassio, S. Monti, A. Rizzello, I. Bettocchi, F. Baronio, G. D’Addabbo, M.O. Bal, A. Balsamo, Comparison between liquid and tablet formulations of levothyroxine in the initial treatment of congenital hypothyroidism. J. Pediatr. 162, 1264–1269 (2013)CrossRefPubMed
17.
Zurück zum Zitat E. Peroni, M.C. Vigone, S. Mora, L.A. Bassi, C. Pozzi, A. Passoni, G. Weber, Congenital hypothyroidism treatment in infants: a comparative study between liquid and tablet formulations of levothyroxine. Horm. Res. Paediatr. 81, 50–54 (2014)CrossRefPubMed E. Peroni, M.C. Vigone, S. Mora, L.A. Bassi, C. Pozzi, A. Passoni, G. Weber, Congenital hypothyroidism treatment in infants: a comparative study between liquid and tablet formulations of levothyroxine. Horm. Res. Paediatr. 81, 50–54 (2014)CrossRefPubMed
18.
Zurück zum Zitat L. Chaker, M.E. van den Berg, M.N. Niemeijer, O.H. Franco, A. Dehghan, A. Hofman, P.R. Rijnbeek, J.W. Deckers, M. Eijgelsheim, B.H. Stricker, R.P. Peeters, Thyroid function and sudden cardiac death: a prospective population-based cohort study. Circulation 134, 713–722 (2016)CrossRefPubMed L. Chaker, M.E. van den Berg, M.N. Niemeijer, O.H. Franco, A. Dehghan, A. Hofman, P.R. Rijnbeek, J.W. Deckers, M. Eijgelsheim, B.H. Stricker, R.P. Peeters, Thyroid function and sudden cardiac death: a prospective population-based cohort study. Circulation 134, 713–722 (2016)CrossRefPubMed
Metadaten
Titel
Is levothyroxine requirement the same for tablet and soft gel formulations?
verfasst von
Vincenzo Di Donna
Rosa Maria Paragliola
Chiara de Waure
Giampaolo Papi
Alfredo Pontecorvi
Salvatore Maria Corsello
Publikationsdatum
02.05.2017
Verlag
Springer US
Erschienen in
Endocrine / Ausgabe 2/2018
Print ISSN: 1355-008X
Elektronische ISSN: 1559-0100
DOI
https://doi.org/10.1007/s12020-017-1311-8

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