Skip to main content
main-content

01.09.2009 | Original Article | Ausgabe 5/2009

Langenbeck's Archives of Surgery 5/2009

Is minimally invasive parathyroidectomy without QPTH monitoring justified?

Zeitschrift:
Langenbeck's Archives of Surgery > Ausgabe 5/2009
Autoren:
Philipp Riss, Christian Scheuba, Reza Asari, Christian Bieglmayer, Bruno Niederle
Wichtige Hinweise
“Best of Endocrine Surgery in Europe 2009”

Abstract

Background

It is matter of discussion if quick parathyroid hormone (QPTH) monitoring is helpful in patients with primary hyperparathyroidism (PHPT) and “localized single-gland disease” (SGD; concordant sestamibi and ultrasound results) to further increase the rate of success (permanent normocalcemia) of performing selective parathyroidectomy by minimally invasive parathyroid exploration (MIP). The aim of this study was to evaluate if a randomized controlled trial was justified in order to clarify this discussion.

Materials and methods

The prospective database of patients with sporadic PHPT, SGD, MIP, and QPTH monitoring (1999–2005) was evaluated regarding the “conversion rate” to bilateral exploration and permanent normocalcemia (“QPTH” group). Retrospectively, the patients were analyzed a second time “without” applying QPTH monitoring (“non-QPTH” group). Statistical differences between both groups were calculated (McNemar’s test).

Results

By definition, 338 patients with “localized SGD” underwent MIP. MIP was finished in 308 (91.1%) patients. Five of 308 patients (1.6%) showed persisting (n = 1) or recurrent disease (n = 4). In 30 of 338 patients (8.9%), a conversion to bilateral exploration was necessary (false preoperative localization 15 patients—one patient not cured; multiple-gland disease correctly indicated by QPTH monitoring 15 patients—one patient not cured). Analyzing the “non-QPTH” group, 14 additional patients showed persisting disease. Thus, without using QPTH monitoring, the rate of persisting PHPT would increase from 0.9% (three patients) to 5.0% (17 patients; p = 0.0005).

Conclusion

Intraoperative QPTH assay seems necessary even in patients with “localized SGD” by two techniques in an endemic goiter region. Abandoning QPTH monitoring would more than double the rate of persisting disease. A randomized trial seems not to be justified.

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

★ PREMIUM-INHALT
e.Med Interdisziplinär

Mit e.Med Interdisziplinär erhalten Sie Zugang zu allen CME-Fortbildungen und Premium-Inhalten der Fachzeitschriften, inklusive eines Print-Abos.

Weitere Produktempfehlungen anzeigen
Literatur
Über diesen Artikel

Weitere Artikel der Ausgabe 5/2009

Langenbeck's Archives of Surgery 5/2009Zur Ausgabe
  1. Das kostenlose Testabonnement läuft nach 14 Tagen automatisch und formlos aus. Dieses Abonnement kann nur einmal getestet werden.

Neu im Fachgebiet Chirurgie

Mail Icon II Newsletter

Bestellen Sie unseren kostenlosen Newsletter Update Chirurgie und bleiben Sie gut informiert – ganz bequem per eMail.

Bildnachweise