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Surgery Today
Erschienen in: Surgery Today 1/2019

25.09.2018 | Original Article

Is neoadjuvant chemotherapy appropriate for patients with resectable liver metastases from colorectal cancer?

verfasst von: Fumitoshi Hirokawa, Mitsuhiro Asakuma, Koji Komeda, Tetsunosuke Shimizu, Yoshihiro Inoue, Syuji Kagota, Atsushi Tomioka, Kazuhisa Uchiyama

Erschienen in: Surgery Today | Ausgabe 1/2019

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Abstract

Purpose

Neoadjuvant chemotherapy (NAC) for resectable liver metastasis from colorectal cancer (CRLM) is used widely, but its efficacy lacks clear evidence. This study aimed to clarify its worth and develop appropriate treatment strategies for CRLM.

Methods

We analyzed, retrospectively, the clinicopathological factors and outcomes of 137 patients treated for resectable CRLM between 2006 and 2015, with upfront surgery (NAC− group; n = 117) or initial NAC treatment (NAC+ group; n = 20).

Results

The time to surgical failure (TSF) and overall survival (OS) after initial treatment were significantly worse in the NAC+ group than in the NAC− group (P = 0.002 and P = 0.032, respectively). At hepatectomy, the NAC+ group had a lower median prognostic nutrition index (PNI), higher rates of a positive Glasgow Prognostic Score (P = 0.002) and more perioperative blood transfusions (P = 0.027) than the NAC− group. Moreover, the serum albumin (P = 0.006), PNI (P ≤ 0.001) and lymphocyte-to-monocyte ratio (P ≤ 0.001) were significantly decreased and the GPS positive rate was increased from 15 to 35% in the NAC+ group. The OS rates did not differ significantly according to the NAC response (5-year OS rates—CR/PR 67%, SD 60%, PD 38%).

Conclusions

Patients with resectable CRLM should undergo upfront hepatectomy because NAC did not improve OS after initial treatment in these patients.
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Metadaten
Titel
Is neoadjuvant chemotherapy appropriate for patients with resectable liver metastases from colorectal cancer?
verfasst von
Fumitoshi Hirokawa
Mitsuhiro Asakuma
Koji Komeda
Tetsunosuke Shimizu
Yoshihiro Inoue
Syuji Kagota
Atsushi Tomioka
Kazuhisa Uchiyama
Publikationsdatum
25.09.2018
Verlag
Springer Singapore
Erschienen in
Surgery Today / Ausgabe 1/2019
Print ISSN: 0941-1291
Elektronische ISSN: 1436-2813
DOI
https://doi.org/10.1007/s00595-018-1716-x

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