To determine the prognostic relevance of neuroendocrine differentiation in poorly differentiated colorectal cancer.
The clinicopathological features and survival of 70 patients with poorly differentiated colorectal cancer were analyzed retrospectively. Chromogranin A and synaptophysin were used as neuroendocrine markers. Patients were followed-up for more than 3 years or until death.
Of these 70 patients, 36 showed neuroendocrine differentiation. In univariate prognostic analysis, the patients with lymph node metastasis (P < 0.001), advanced TNM stage (P < 0.001), and neuroendocrine differentiation (P = 0.003) tended to have a poor prognosis. However, only lymph node metastasis was associated with a poor prognosis in multivariate analysis (P < 0.001). Patients with neuroendocrine differentiation were associated with lymph node metastasis (P = 0.006).
Neuroendocrine differentiation in poorly differentiated colorectal cancer was not a direct prognostic factor in these patients. Lymph node metastasis was a direct prognostic factor in these patients. Patients with neuroendocrine differentiation were associated with lymph node metastasis.
Shinji S, Naito Z, Ishiwata T, Tanaka N, Furukawa K, Suzuki H, et al. Neuroendocrine cell differentiation of poorly differentiated colorectal adenocarcinoma correlates with liver metastasis. Int J Oncol. 2006;29:357–64. PubMed
Taniyama K, Suzuki H, Matsumoto M, Hakamada K, Toyama K, Tahara E. Flow cytometric DNA analysis of poorly differentiated adenocarcinoma of the colorectum. Jpn J Clin Oncol. 1991;21:406–11. PubMed
Liu Y, Xu J, Jiao Y, Hu Y, Yi C, Li Q, et al. Neuroendocrine differentiation is a prognostic factor for stage II poorly differentiated colorectal cancer. Biomed Res Int. 2014; doi: 10.1155/2014/789575.
Le VTE, Sigurdson ER, Hanlon AL, Mayer RJ, Macdonald JS, Catalano PJ, et al. Colon cancer survival is associated with increasing number of lymph nodes analyzed: a secondary survey of intergroup trial INT-0089. J Clin Oncol. 2003;21:2912–9. CrossRef
Johnson LR. Regulation of gastrointestinal mucosal growth. Physiol Rev. 1988;68:456–502. PubMed
Carney DN, Mitchell JB, Kinsella TJ. In vitro radiation and chemotherapy sensitivity of established cell lines of human small cell lung cancer and its large cell morphological variants. Cancer Res. 1983;43:2806–11. PubMed
Park JG, Oie HK, Sugarbaker PH, Henslee JG, Chen TR, Johnson BE, et al. Characteristics of cell lines established from human colorectal carcinoma. Cancer Res. 1987;47:6710–8. PubMed
- Is neuroendocrine differentiation a prognostic factor in poorly differentiated colorectal cancer?
- BioMed Central
Neu im Fachgebiet Chirurgie
Mail Icon II