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01.12.2017 | Research | Ausgabe 1/2017 Open Access

World Journal of Surgical Oncology 1/2017

Is neuroendocrine differentiation a prognostic factor in poorly differentiated colorectal cancer?

Zeitschrift:
World Journal of Surgical Oncology > Ausgabe 1/2017
Autoren:
Yue Chen, Fang Liu, Qingkai Meng, Siping Ma

Abstract

Background

To determine the prognostic relevance of neuroendocrine differentiation in poorly differentiated colorectal cancer.

Methods

The clinicopathological features and survival of 70 patients with poorly differentiated colorectal cancer were analyzed retrospectively. Chromogranin A and synaptophysin were used as neuroendocrine markers. Patients were followed-up for more than 3 years or until death.

Results

Of these 70 patients, 36 showed neuroendocrine differentiation. In univariate prognostic analysis, the patients with lymph node metastasis (P < 0.001), advanced TNM stage (P < 0.001), and neuroendocrine differentiation (P = 0.003) tended to have a poor prognosis. However, only lymph node metastasis was associated with a poor prognosis in multivariate analysis (P < 0.001). Patients with neuroendocrine differentiation were associated with lymph node metastasis (P = 0.006).

Conclusions

Neuroendocrine differentiation in poorly differentiated colorectal cancer was not a direct prognostic factor in these patients. Lymph node metastasis was a direct prognostic factor in these patients. Patients with neuroendocrine differentiation were associated with lymph node metastasis.
Literatur
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