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The journal of nutrition, health & aging

Erschienen in:

04.10.2019

Is Polypharmacy Associated with Cognitive Frailty in the Elderly? Results from the Korean Frailty and Aging Cohort Study

verfasst von: J. H. Moon, J. S. Huh, Chang Won Won, Hyeon Ju Kim

Erschienen in: The journal of nutrition, health & aging | Ausgabe 10/2019

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Abstract

Objectives

Cognitive frailty — the coexistence of physical frailty and cognitive impairment—is a phenotype of frailty in the elderly. The coexistence of physical frailty and cognitive impairment, known as cognitive frailty, is one of the phenotypes of frailty in the elderly. Cognitive frailty predicts adverse health outcome more accurately than does physical frailty. In this study, we aim to determine whether the polypharmacy common among the elderly is linked with cognitive frailty.

Design, Setting, and Participants

The elderly, aged between 70 and 84 years, who participated in the cross-sectional Korean Frailty and Aging Cohort Study were included in the present study.

Measurements

Polypharmacy and hyperpolypharmacy were defined as the use of at least five and ten medications, respectively. Physical frailty was assessed by the Korean version of the FRAIL scale, and cognitive status was measured by the Trail Making Test part A, word list recall test, the Korean version of the Frontal Assessment Battery, and the Digit Span Backward test.

Results

Among the 2,392 participants, 26.8% and 4.1% took more than five and ten prescribed medications, respectively. Polypharmacy and hyperpolypharmacy participants tend to have more cognitive impairment and physical frailty. Participants with cognitive frailty had the highest polypharmacy rate regardless of medication type. After controlling for the potential confounders including severity of comorbidities, frailty was found to be significantly related to polypharmacy, as defined by prescribed as well as total medications, including non-prescribed medications. However, cognitive impairment only showed a linkage to polypharmacy of prescribed medications, which—according to the results of multivariable analysis— could increase cognitive frailty, with an odds ratio of 2.70.

Conclusion

Although the elderly tend to depend on various medications, they should seriously consider the risk of polypharmacy for better health outcomes.

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Titel: Is Polypharmacy Associated with Cognitive Frailty in the Elderly? Results from the Korean Frailty and Aging Cohort Study
verfasst von: J. H. Moon
J. S. Huh
Chang Won Won
Hyeon Ju Kim
Publikationsdatum: 04.10.2019
Verlag: Springer Paris
Erschienen in: The journal of nutrition, health & aging / Ausgabe 10/2019
Print ISSN: 1279-7707
Elektronische ISSN: 1760-4788
DOI: https://doi.org/10.1007/s12603-019-1274-y

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Is Polypharmacy Associated with Cognitive Frailty in the Elderly? Results from the Korean Frailty and Aging Cohort Study

Abstract

Objectives

Design, Setting, and Participants

Measurements

Results

Conclusion

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Abstract

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Results

Conclusion

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