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Inflammopharmacology
Erschienen in: Inflammopharmacology 3/2018

07.05.2018 | Commentary

Is the pharmaceutical industry’s preoccupation with the monotherapy drug model stifling the development of effective new drug therapies?

verfasst von: Ian Edwin Cock

Erschienen in: Inflammopharmacology | Ausgabe 3/2018

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Abstract

Drug discovery and development is heavily biased towards the development of monotherapies. Screening, testing, and evaluation of mono-entity drugs are generally much simpler than drug combinations, and are generally easier to get approval from the regulatory authorities for their clinical use. However, monotherapy drugs may not have optimal activity, may have associated toxicities, or may lose activity over time as their target develops resistance. Drug combinations, often developed from existing monotherapies, may have improved efficacy and/or be less toxic. Furthermore, the existing drugs which have lost efficacy due to the development of resistance can often be re-activated by combining them with other chemical entities. Thus, whilst the current climate for drug approval, registration, and clinical use drives the majority of drug development research towards the development of monotherapies, combinations are often a substantial improvement on the original drug. This commentary examines monotherapy and combinational therapy models and discusses the benefits and limitations of each model.
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Metadaten
Titel
Is the pharmaceutical industry’s preoccupation with the monotherapy drug model stifling the development of effective new drug therapies?
verfasst von
Ian Edwin Cock
Publikationsdatum
07.05.2018
Verlag
Springer International Publishing
Erschienen in
Inflammopharmacology / Ausgabe 3/2018
Print ISSN: 0925-4692
Elektronische ISSN: 1568-5608
DOI
https://doi.org/10.1007/s10787-018-0488-7

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