Type 2 diabetes mellitus (T2DM) is one of the most important leading causes of disability, premature mortality and Diabetic Retinopathy (DR) that is one of the diabetes-related complications in diabetic patients and the most common cause of vision loss in diabetic patients. The aim of the study was to evaluate the association between DR and body mass index (BMI) in those patients with T2DM.
This was a central-based, cross-sectional study on 518 diabetic patients. Their medical history and the laboratory data were collected. All the patients received examination of diabetic retinopathy by professional ophthalmologist. Based on their optic fundi findings, they were classified into five groups: No retinopathy, Mild Non-proliferative Diabetic Retinopathy (NPDR), Moderate NPDR, Severe NPDR, Proliferative diabetic retinopathy (PDR). To analysis data SPSS v18 software used. Frequency, percent, mean and standard deviation were used for population description. t test, spearman correlation, partial correlation, analysis of variance (ANOVA) and Chi-square test (χ2) were used for analytic analysis. Multivariate logistic regression was used to estimate the odds ratio.
518 patients with T2DM 198 male (38%), 320 female (62%) included in this study. The mean age of patients was 61.02 ± 10.18 years. The mean age at onset was 49.06 + 10.52 years and the mean duration of diabetes was 12.09 ± 7.81 years. There was a strong relationship between duration of diabetes and DR (P = 0.001). There were strong significant association between the development of DR and Insulin therapy (OR = 5.975). Correlation analysis between Retinopathy and BMI showed that BMI had inverse relationship with DR when BMI considered as a continuous variable (p-value = 0.009 and correlation coefficient = −0.467).
BMI in diabetic patient is one of the most important clinical parameter for their health and disease progression. We conclude that BMI had inverse relationship with DR when BMI considered as a continuous variable.
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Beaglehole R, Epping-Jordan J. Preventing chronic diseases, a vital investment. Geneva: World Health Organization; 2005.
World Health Organization. Prevention of diabetes mellitus. Report of a WHO study group. Geneva: World Health Organization No 844; 1994.
US Centers for Disease Control and Prevention. National Diabetes Fact Sheet: general information and National Estimates on diabetes in the United States. Atlanta, GA: centers for disease control and Prevention; 2005.
UK Prospective Diabetes Study (UKPDS) Group, author. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet. 1998;352:837–53. CrossRef
Tyrberg M, Nyström L, Arnqvist HJ, Bolinder J, Gudbjörnsdottir S, Landin-Olsson M, et al. Hyperglycemia and tobacco use are modifiable risk factors for onset of retinopathy 9 and 17 years after the diagnosis of diabetes-a retrospective observational nation-wide cohort study. Diabetes Res Clin Pract. 2017 Aug 24;133:21–9. CrossRefPubMed
Nilsson SV, Nilsson JE, Frostberg N, Emilsson T. The Kristianstad survey. II. Studies in a representative adult diabetic population with special reference to comparison with an adequate control group. Acta Med Scand Suppl. 1967;469:1–42. PubMed
Kaštelan S, Tomić M, Gverović Antunica A, Ljubić S, Salopek Rabatić J, Karabatić M. Body mass index: a risk factor for retinopathy in type 2 diabetic patients. Mediat Inflamm 2013 Nov 20;2013.
Narendra V, John RK, Raghuram A, Ravindran RD, Nirmalan PK, Thulasiraj RD. Diabetic retinopathy among selfreported diabetics in southern India: a population-based assessment. Br J Ophthalmol. 2002;86:1014–8. CrossRef
National Institute of Diabetes and Digestion and Kidney Diseases. Clinical Guidelines on the Identification, Evaluation, and Treatment of overweight and obesity in adults: The Evidence Report. Bethesda (MD): National Heart, Lung, and Blood Institute; 1998 Sep. Report No.: 98–4083 Am J Clin Nutr 68(4):899–917.
World Health Organization. Global strategy for noncommunacable disease prevention and control. Geneva. Switzerland: World Health Organization; 1997.
Lu J, Hou X, Zhang L, Jiang F, Hu C, Bao Y, et al. Association between body mass index and diabetic retinopathy in Chinese patients with type 2 diabetes. Acta Diabetol. 2015:1–8.
Logue J, Walker JJ, Leese G et al (2013) Association between BMI measured within a year after diagnosis of type 2 diabetes and mortality. Diabetes Care. 2013;36:887–93.
He BB, Wei L, Gu YJ et al. Factors associated with diabetic retinopathy in Chinese patients with type 2 diabetes mellitus. Int J Endocrinol 2012.
Manaviat MR, Afkhami M. Shoja MR retinopathy and microalbuminuria in type II diabetic patients. BMC Ophthalmol. 2004;1:4–9.
- Is there a relationship between body mass index and diabetic retinopathy in type II diabetic patients? A cross sectional study
Masoud Reza Manaviat
- Springer International Publishing
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