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Erschienen in: European Journal of Clinical Microbiology & Infectious Diseases 1/2017

07.09.2016 | Original Article

Is there an association between prior anti-inflammatory drug exposure and occurrence of peritonsillar abscess (PTA)? A national multicenter prospective observational case–control study

verfasst von: D. Lepelletier, V. Pinaud, P. Le Conte, C. Bourigault, N. Asseray, F. Ballereau, J. Caillon, C. Ferron, C. Righini, E. Batard, G. Potel, for the French PTA Study Group

Erschienen in: European Journal of Clinical Microbiology & Infectious Diseases | Ausgabe 1/2017

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Abstract

The aim of this study was to evaluate whether recent systemic anti-inflammatory agents (AIAs) exposure in patients with sore throat managed with or without antibiotic therapy influenced the risk of peritonsillar abscess (PTA). We conducted a multicenter case–control study in 13 French university hospitals in 2009–2012 comparing patients admitted with PTA to matched controls: patients with sore throat but without PTA who were followed up for 10 days after visiting their primary-care physician. In the multivariate stepwise logistic regression model comparing 120 cases with PTA to 143 controls, factors significantly associated with PTA were male gender (odds ratio [OR], 2.0; p = 0.03), smoking (OR, 2.0; p = 0.03), and prior self-medication with systemic AIAs (OR, 3.5; p = 0.01). Topical treatment was associated with significant protection against PTA (OR, 0.3; p < 0.001). In conclusion, self-medication with systemic AIAs appears to be an independent factor associated with the occurrence of PTA. This is an important message as non-steroidal AIAs access is favored by their over-counter availability in pharmacies. This finding must be interpreted with caution due to the study design and a prospective, randomized study is needed to substantiate these possible causal risk factors.
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Metadaten
Titel
Is there an association between prior anti-inflammatory drug exposure and occurrence of peritonsillar abscess (PTA)? A national multicenter prospective observational case–control study
verfasst von
D. Lepelletier
V. Pinaud
P. Le Conte
C. Bourigault
N. Asseray
F. Ballereau
J. Caillon
C. Ferron
C. Righini
E. Batard
G. Potel
for the French PTA Study Group
Publikationsdatum
07.09.2016
Verlag
Springer Berlin Heidelberg
Erschienen in
European Journal of Clinical Microbiology & Infectious Diseases / Ausgabe 1/2017
Print ISSN: 0934-9723
Elektronische ISSN: 1435-4373
DOI
https://doi.org/10.1007/s10096-016-2770-1

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