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Erschienen in: Documenta Ophthalmologica 2/2020

Open Access 20.11.2019 | ISCEV Standards

ISCEV extended protocol for the S-cone ERG

verfasst von: Ido Perlman, Mineo Kondo, Enid Chelva, Anthony G. Robson, Graham E. Holder

Erschienen in: Documenta Ophthalmologica | Ausgabe 2/2020

Abstract

The International Society for Clinical Electrophysiology of Vision (ISCEV) standard for full-field electroretinography (ERG) describes a minimum procedure for testing generalized retinal function but encourages more extensive testing. This extended protocol describes a method of assessing the function of the short-wavelength-sensitive cone (S-cone) retinal pathway, using a short-wavelength flash superimposed on a background that saturates the rods and adapts the L/M-cones to elicit a response, known as the S-cone ERG. Stimulus parameters such as the strength and luminance of the flash and background, respectively, and their spectral and temporal characteristics are specified. As a complement to the ISCEV standard, testing the S-cone ERG enables further characterization of light-adapted retinal function and may refine diagnosis of some retinal disorders. Typical applications are described including use in the diagnosis of rod monochromacy and S-cone monochromacy, identification and investigation of cone On-bipolar cell dysfunction and use of the technique to confirm the diagnosis of enhanced S-cone syndrome.
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Introduction

The International Society for Clinical Electrophysiology of Vision (ISCEV) standard for full-field electroretinography (ERG) describes a minimum procedure for testing generalized retinal function but encourages more extensive testing [1]. This extended protocol describes a method of assessing the function of the short-wavelength-sensitive cone (S-cone) retinal pathway, using a short-wavelength flash superimposed on a background light to elicit a response, known as the S-cone ERG. The S-cone ERG is a specialized procedure which is well established and broadly accepted by experts in the field. The protocol was prepared by the authors in accordance with ISCEV procedures (http://​www.​iscev.​org/​standards/​index.​html) and approved by the ISCEV Board of Directors on September 23rd, 2019.

Scope and application

The ISCEV standard ERGs are recorded under dark-adapted (DA) and light-adapted (LA) conditions to assess both rod and cone system functions. The standard LA ERGs are normally dominated by responses driven by the long-wavelength-sensitive cones (L-cones) and medium-wavelength-sensitive cones (M-cones). There are far fewer short-wavelength-sensitive cones (S-cones) than L/M-cones, and their summed responses to light are of smaller amplitude and slower kinetics. Therefore, the S-cone-mediated retinal activity is not directly visible in the standard LA ERGs. This extended protocol describes parameters for the recording of the S-cone ERG, reflecting the activity of the S-cone pathways in the distal retina. The S-cone ERG is elicited using short-wavelength (blue) flashes on a long-wavelength background to saturate the rod system and to reduce contributions from the L/M-cone systems [24]. The ERGs to such stimuli normally vary in waveform shape according to flash strength. To dim stimuli, there is typically a single low-amplitude component of relatively long peak time (Fig. 1). To stronger flashes, an additional earlier peak occurs and grows with increasing flash strength. The action spectrum of the 1st peak has a maximum at 520 nm and that of the 2nd peak at 450 nm [3]. In S-cone monochromacy, there is a later peak only [3], whereas in tritanopia there may be a normal 1st peak and a very small 2nd peak [4]. These and other studies are consistent with response contributions from the L/M-cone system to the first peak and the S-cone system to the second peak.
The addition of S-cone ERG testing to the standard ERG protocol enables further characterization of LA retinal function and can help in determining the origin of abnormal standard ERGs. Typical clinical applications of S-cone ERGs are outlined below:
a.
In inherited retinal disorders, a more detailed knowledge of the phenotype may refine the diagnosis and facilitate mutational screening. It can confirm the origins of the recorded signals in enhanced S-cone syndrome (ESCS) consequent upon mutation in NR2E3 gene after the pathognomonic features have been revealed with conventional ISCEV standard ERG testing [5, 6]. Mutations in the NRL gene, the upstream gene to NR2E3, also cause a retinal phenotype similar to ESCS, but not identical in all ERG features [7, 8].
 
b.
S-cone ERG recording is important in the distinction between rod monochromacy and S-cone monochromacy. In both disorders, the rod-driven ERG components are normal or well-preserved. The LA 3.0 ERG is usually undetectable in rod monochromacy, but in S-cone monochromacy may be detectable as a small amplitude b-wave of long implicit time appearing at approximately 50 ms, suggestive of an S-cone system origin that can be more accurately confirmed by S-cone ERG recording [2]. S-cones, like rods, transmit signals via an On-bipolar cell pathway, and any disorder affecting global retinal On-pathway function, such as “complete” CSNB (congenital stationary night blindness), will have reduced S-cone ERGs [9].
 
c.
Inherited tritanopia is rare, and such patients cannot be identified with Ishihara plates, but only by testing color vision in the tritan color confusion axis (e.g., HRR plates, Farnsworth-Munsell 100-Hue, L’Anthony D15, color contrast sensitivity, etc.). Although many patients with tritanopic defects may have normal S-cone ERGs, some patients show S-cone ERG abnormalities [4].
 
d.
Elevated tritan thresholds can also occur in acquired disorders associated with reduction in S-cone pathway function. Examples include melanoma-associated retinopathy, characterized by ERGs indistinguishable from those in complete congenital stationary night blindness, and reflecting On-bipolar cell dysfunction. Tritan defects may also occur in vitamin A deficiency, where some patients report seeing “white as green” as a result of loss of S-cone function, and in diabetes. The recovery of S-cone function following vitamin A supplementation can be monitored with S-cone ERGs [10].
 

Patient population

Patients of all ages, able to tolerate Ganzfeld stimulation, referred for investigation of possible retinal dysfunction, retinal dystrophy, generalized cone or rod system dysfunction or patients with photophobia and/or nystagmus may benefit from the S-cone ERG, performed in addition to the ISCEV standard ERG.

Technical issues

S-cone ERG recording is performed following the specifications of the current ISCEV standard for full-field ERG [1]. Recordings of the S-cone ERG can be embedded within the standard protocol [1] or conducted as a separate protocol. Additional factors are outlined below:
a.
Spectral characteristics and luminance of the background
 
The photopic background for the recording of the S-cone ERG must be of spectral composition and strength that will achieve two goals: (1) saturate the rod system and (2) minimize the contributions of the L/M-cones systems. The initial studies used a white background, but later studies and the developments of new electrophysiology of vision systems indicated that bright LEDs with spectral peaks between 570 and 620 nm (yellow, amber, orange) were more suitable for the purpose of obtaining an S-cone ERG (Table 1). A high background luminance of appropriate wavelength may optimize isolation of S-cone-mediated responses, but patient comfort, tolerance and the possibility of photophobia must also be considered.
Table 1
Stimulus and background conditions for recording S-cone ERG
References
Stimulus wavelength
Stimulus strength
Rate of stimulus (Hz)
Background wavelength
Background luminance
Norren et al. [11, 12]
441 nm (interference filter)
Not stated
Not stated
Yellow (> 530 nm)
3.0–6.0 log Td
Yokoyama et al. [13]
440 nm (interference filter)
0.63 W/m2
Not stated
Yellow
13 Wm2
Miyake et al. [14]
440 nm (interference filter)
7.58 μW/cm2
3
Yellow
204 μW/cm2
Gouras et al. [2, 3]
450 nm (Wratten 98)
approximately 0.02 μW
5.1
White
>5000–9000 Td (> 100 cd/m2)
Yamamoto et al. [15, 16]
450 nm (Wratten 98)
Xenon flash of 5.0 cd s m−2 and Wratten 98
5
White
1.7 log cd m−2 (50 cd m−2)
Horiguchi et al. [17]
450 nm (LED)
Long flash of 2.8 log Td (12.6 cd m−2)
3
Wratten 12 (Yellow)
4.8 log Td (= 1262 cd m−2)
Simonsen et al. [18]
440 nm (Wratten 98)
Xenon flash of 2.1 cd s m−2 and Wratten 98
4
Yellow
100 cd m−2
Arden et al. [4]
440 nm (LED)
0.3–1.5 log Td–s (= 0.04–0.6 cd s m−2)
Not stated
610 nm (orange)
18,900 Td (= 378 cd m−2)
Maeda et al. [19]
450 nm (Wratten 98)
Xenon flash of 5.0 cd s m−2 and Wratten 98
5 Hz
White
1.7 logcd m−2 (50 cd m−2)
Chiti et al. [20]
Combination of two filters of 430 and 450 nm
0.034 cd s m2 (= 1.71 Td–s)
2
Yellow
10,807 Td (= 215 cd m−2)
Marmor et al. [21]
440 nm (LED)
0.03–0.05 cd s/m−2
4
590 nm (orange)
300 cd m−2
Tsuruoka et al. [22]
430 nm (LED)
0.03 cd s m−2 (− 1.5 log cd s m−2)
1–5
White
2.0 log  cd m−2 (100 cd m−2)
Audo et al. [5]
445 nm (LED)
0.08–0.8 cd s m−2 (80 cd m−2 with 1–10 ms flashes)
Not stated
620 nm (orange)
560 cd m−2
Sustar et al. [6], [23]
449 nm (Wratten 47B)
0.016–0.125 cd s m−2
2
594 nm (amber)
100 cd m−2
Rocha-Sousa et al. [24]
440 nm
65 cd m−2, 10 ms
Not stated
660 nm (orange)
350 cd m−2
Cima et al. [25]
449 nm (Wratten 47B)
0.016 cd s m−2
2
594 nm (amber)
100 cd m−2
Schatz et al. [26]
470 nm (LED)
0.1–0.5 cd s m−2
Not stated
594 nm (amber)
500 cd m−2
Campi et al. [27]
blue 445 nm
0.4 cd s m−2
1
600 nm (orange)
560 cd m−2
Littink et al. [8]
Blue (445 nm) (LED)
2.0 cd s m−2
Not stated
594 nm (amber)
15 cd m−2
b.
Spectral characteristics of the test flash
 
Short-wavelength (blue) stimuli may be generated using Xenon light in combination with a suitable optical filter (Kodak #98, having a peak transmission at 450 nm) or by using a light emitting diode (LED) with a peak output of short wavelength, in the region of 440–470 nm (Table 1). Wavelengths longer than 470 nm typically generate ERGs that are dominated by the L/M-cones, and the contribution of the S-cones to the ERG may not be detectable. Light sources with wavelength shorter than 440 nm may not have sufficient strength to elicit a reliable S-cone ERG because the S-cone ERG action spectrum peaks at 450 nm [3].
c.
Strength of the test flash
 
Laboratories that use backgrounds of 300 cd m−2 have used flashes of low strength, 0.03–0.05 cd s m−2, while laboratories using bright backgrounds of about 500 cd m−2 use stronger flashes, 0.1–0.5 cd s m−2, in order to elicit robust S-cone mediated responses (Table 1). Weak flashes may be more selective but elicit responses of relatively low amplitude (Fig. 1), whereas stronger stimuli may be difficult for some patients to tolerate.
d.
Units of flash strength and luminance
 
It is acknowledged that the strength of the colored flash requires consideration of the spectral sensitivity of the eye and is accurately described by radiant energy (Watts/steradian/m2/nm), but for uniformity of clinical use and consistency with other brief flash stimuli, strength is defined in this protocol in units of cd s m−2. For stimulus durations > 10 ms, stimulus strength is given in units of luminance (cd m−2).

Calibration

Calibration in accordance with the ISCEV standard ERG is recommended [1]. A spectral photometer is required to determine the spectral characteristics of the short-wavelength flash. Care should be taken to measure a range of flash luminance levels as some Ganzfeld stimulators use different combinations and banks of LEDs for different luminance ranges, and these may have different wavelength specifications.

Protocol specifications

Patient preparation follows that for the current ISCEV standard ERG [1]. For routine applications, the S-cone ERG protocol may be added to the ISCEV standard protocol after the other LA ERGs. Additional specifications are outlined in Table 1.
a.
Spectral characteristics and luminance of the background.
 
The background peak wavelength is between 570 and 620 nm (yellow, amber, orange). The background luminance is 300 cd m−2. Recordings obtained using higher luminance backgrounds may be added (see section c).
b.
Spectral characteristics of the test flash
 
For routine clinical diagnostics, LEDs with peak wavelength of between 450 nm and 470 nm are specified. If Xenon flashes and filters are used, a blue filter (Kodak #98 with peak transmission at 450 nm) is used. The method of stimulation (LED or optical filter) and the peak wavelength and bandwidth at half-height of the stimulus should be stated.
c.
Stimulus strength
 
The minimum S-cone ERG protocol includes a stimulus strength of 0.05 cd s m−2 delivered on a background luminance of 300 cd m−2. This does not preclude the recording of additional S-cone ERGs or an S-cone ERG stimulus–response series, e.g., stimuli ranging from approximately 0.025 to 0.2 cd s m−2 (see Fig. 1). Additional stronger flashes (e.g., 0.1–0.5 cd s m−2) on a brighter background luminance (e.g., 500–560 cd m−2) can be used but may be difficult for some patients to tolerate.
d.
Flash duration and frequency of presentation
 
Flash duration should be equal or less than 5 ms. The presentation rate is 2 Hz (inter-stimulus interval 0.5 s) as for the ISCEV standard LA3ERG.
e.
Signal averaging
 
Small responses to dim flashes or abnormally reduced S-cone ERG components may require signal averaging of up to several hundred recordings.
f.
Duration of light adaptation
 
When the S-cone ERG protocol is embedded in the full-field ERG protocol and conducted as a continuation of the light-adapted ERG recording, then the 10 min adaptation to the light-adapted background (white light 30 cd m−2) is sufficient before starting to record the S-cone ERG. However, if the S-cones ERG protocol is used as a stand-alone protocol, light adaptation to the background should proceed for 10 min before starting to record the S-cone ERG.

Response evaluation

The waveform is evaluated as having a single or double peak. If there are two peaks, the peak time is measured from stimulus onset to the 2nd (S-cone-mediated) peak. Amplitude is measured from baseline to the peak or from the trough that follows the 1st peak to the peak of the following positive wave depending upon response waveform (Fig. 2).

Reporting

Reporting the S-cone ERG should follow the recommendations of the ISCEV standard ERG [1]. The spectral characteristics of the stimulus and background should be specified. The strength and duration of the light stimulus and the luminance of the background should be stated. The presence or absence of a 2-peak ERG pattern should be acknowledged, and amplitude and peak time of the 2nd peak should be reported as S-cone ERG along with age-appropriate laboratory reference data. If not already documented as part of the ISCEV standard ERG, pupil diameters following mydriasis should be documented. It is acknowledged that for routine diagnostic reporting it may be enough to describe the S-cone ERG qualitatively.

Compliance with ethical standards

Conflict of interest

All authors declare that they have no conflict of interest.

Statements of human rights

The procedures that were used to obtain the data shown in figures 1 and 2, adhered to the tenents of the Word Medical Association Declaration of Helsinki.

Statement on the welfare of animals

Not applicable.
A written informed consent was signed by the subjects after they were provided with sufficient information on the procedures to be used.
Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://​creativecommons.​org/​licenses/​by/​4.​0/​), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Appendix: Justification for the protocol details and excluded methods

A literature review was performed with PubMed search to find the publications that reported recordings of S-cone ERG using the following keywords: (S-cone or blue-cone) and (electroretinogram or ERG). Only the reports of S-cone ERG using a blue flash on strong adapting background illumination to suppress M- and L-cone activities were extracted. Animal studies were excluded, as well as studies using focal types of stimulation. Reports of S-cone ERG recording using silent substitution methods were also excluded. Studies from the year 1970 to 2018 were reviewed, and those with specified stimulus parameters are summarized in Table 1.
Literatur
1.
Zurück zum Zitat McCulloch DL, Marmor MF, Brigell MG, Hamilton R, Holder GE, Tzekov R, Bach M (2015) ISCEV Standard for full-field clinical electroretinography (2015 update). Doc Ophthalmol 130:1–12CrossRef McCulloch DL, Marmor MF, Brigell MG, Hamilton R, Holder GE, Tzekov R, Bach M (2015) ISCEV Standard for full-field clinical electroretinography (2015 update). Doc Ophthalmol 130:1–12CrossRef
2.
Zurück zum Zitat Gouras P, MacKay CJ (1990) Electroretinographic responses of the short-wavelength-sensitive cones. Invest Ophthalmol Vis Sci 31:1203–1209PubMed Gouras P, MacKay CJ (1990) Electroretinographic responses of the short-wavelength-sensitive cones. Invest Ophthalmol Vis Sci 31:1203–1209PubMed
3.
Zurück zum Zitat Gouras P, MacKay CJ, Yamamoto S (1993) The human S-cone electroretinogram and its variation among subjects with and without L and M-cone function. Invest Ophthalmol Vis Sci 34:2437–2442PubMed Gouras P, MacKay CJ, Yamamoto S (1993) The human S-cone electroretinogram and its variation among subjects with and without L and M-cone function. Invest Ophthalmol Vis Sci 34:2437–2442PubMed
4.
Zurück zum Zitat Arden G, Wolf J, Berninger T, Hogg CR, Tzekov R, Holder GE (1999) S-cone ERGs elicited by a simple technique in normal and in tritanopes. Vis Res 39:641–650CrossRef Arden G, Wolf J, Berninger T, Hogg CR, Tzekov R, Holder GE (1999) S-cone ERGs elicited by a simple technique in normal and in tritanopes. Vis Res 39:641–650CrossRef
5.
Zurück zum Zitat Audo I, Michaelides M, Robson AG, Hawlina M, Vaclavik V, Sanbach JM, Neveu MM, Hogg CR, Hunt DM, Moore AT, Bird AC, Webster AR, Holder GE (2008) Phenotypic variations in enhanced S-cone syndrome. Invest Ophthalmol Vis Sci 49:2082–2093CrossRef Audo I, Michaelides M, Robson AG, Hawlina M, Vaclavik V, Sanbach JM, Neveu MM, Hogg CR, Hunt DM, Moore AT, Bird AC, Webster AR, Holder GE (2008) Phenotypic variations in enhanced S-cone syndrome. Invest Ophthalmol Vis Sci 49:2082–2093CrossRef
6.
Zurück zum Zitat Sustar M, Perovsek D, Cima I, Stirn-Kranjc M, Hawlina M, Brecelj J (2015) Electroretinography and optical coherence tomography reveal abnormal post-receptoral activity and altered retinal lamination in patients with enhanced S-cone syndrome. Doc Ophthalmol 130:165–177CrossRef Sustar M, Perovsek D, Cima I, Stirn-Kranjc M, Hawlina M, Brecelj J (2015) Electroretinography and optical coherence tomography reveal abnormal post-receptoral activity and altered retinal lamination in patients with enhanced S-cone syndrome. Doc Ophthalmol 130:165–177CrossRef
7.
Zurück zum Zitat Newman H, Blumen SC, Braverman I, Hanna R, Tiosano B, Perlman I, Ben-Yosef T (2016) Homozygosity for a recessive loss-of-function mutation of the NRL gene is associated with a variant of enhanced S-cone syndrome. Invest Ophthalmol Vis Sci 57:5361–5371CrossRef Newman H, Blumen SC, Braverman I, Hanna R, Tiosano B, Perlman I, Ben-Yosef T (2016) Homozygosity for a recessive loss-of-function mutation of the NRL gene is associated with a variant of enhanced S-cone syndrome. Invest Ophthalmol Vis Sci 57:5361–5371CrossRef
9.
Zurück zum Zitat Kamiyama M, Yamamoto S, Nitta K, Hayasaka S (1996) Undetectable S cone electroretinogram b-wave in complete congenital stationary night blindness. Br J Ophthalmol 80:637–639CrossRef Kamiyama M, Yamamoto S, Nitta K, Hayasaka S (1996) Undetectable S cone electroretinogram b-wave in complete congenital stationary night blindness. Br J Ophthalmol 80:637–639CrossRef
10.
Zurück zum Zitat McBain VA, Egan CA, Pieris SJ, Supramaniam G, Webster AR, Bird AC, Holder GE (2005) Functional observations in vitamin A deficiency: diagnosis and time-course of recovery. Eye 21:367–376CrossRef McBain VA, Egan CA, Pieris SJ, Supramaniam G, Webster AR, Bird AC, Holder GE (2005) Functional observations in vitamin A deficiency: diagnosis and time-course of recovery. Eye 21:367–376CrossRef
11.
Zurück zum Zitat Norren DV, Padmos P (1973) Human and macaque blue cones studied with electroretinography. Vision Res 13:1241–1254CrossRef Norren DV, Padmos P (1973) Human and macaque blue cones studied with electroretinography. Vision Res 13:1241–1254CrossRef
12.
Zurück zum Zitat Padmos P, van Norren D, Faijer JW (1978) Blue cone function in a family with an inherited tritan defect, tested with electroretinography and psychophysics. Invest Ophthalmol Vis Sci 17:436–441PubMed Padmos P, van Norren D, Faijer JW (1978) Blue cone function in a family with an inherited tritan defect, tested with electroretinography and psychophysics. Invest Ophthalmol Vis Sci 17:436–441PubMed
13.
Zurück zum Zitat Yokoyama M, Yoshida T, Ui K (1973) Spectral responses in the human electroretinogram and their clinical significance. Jpn J Ophthalmol 17:113–124 Yokoyama M, Yoshida T, Ui K (1973) Spectral responses in the human electroretinogram and their clinical significance. Jpn J Ophthalmol 17:113–124
14.
Zurück zum Zitat Miyake Y, Yagasaki K, Ichikawa H (1985) Differential diagnosis of congenital tritanopia and dominantly inherited juvenile optic atrophy. Arch Ophthalmol 103:1496–1501CrossRef Miyake Y, Yagasaki K, Ichikawa H (1985) Differential diagnosis of congenital tritanopia and dominantly inherited juvenile optic atrophy. Arch Ophthalmol 103:1496–1501CrossRef
15.
Zurück zum Zitat Yamamoto S, Kataoka Y, Kamiyama M, Hayasaka S (1995) Nondetectable S-cone electroretinogram in a patient with crystalline retinopathy. Doc Ophthalmol 90:221–227CrossRef Yamamoto S, Kataoka Y, Kamiyama M, Hayasaka S (1995) Nondetectable S-cone electroretinogram in a patient with crystalline retinopathy. Doc Ophthalmol 90:221–227CrossRef
16.
Zurück zum Zitat Yamamoto S, Hayashi M, Takeuchi S, Shirao Y, Kita K, Kawasaki K (1997) Normal S cone electroretinogram b-wave in Oguchi’s disease. Br J Ophthalmol 81:1043–1045CrossRef Yamamoto S, Hayashi M, Takeuchi S, Shirao Y, Kita K, Kawasaki K (1997) Normal S cone electroretinogram b-wave in Oguchi’s disease. Br J Ophthalmol 81:1043–1045CrossRef
17.
Zurück zum Zitat Horiguchi M, Miyake Y, Kondo M, Suzuki S, Tanikawa A, Koo HM (1995) Blue light-emitting diode built-in contact lens electrode can record human S-cone electroretinogram. Invest Ophthalmol Vis Sci 36:1730–1732PubMed Horiguchi M, Miyake Y, Kondo M, Suzuki S, Tanikawa A, Koo HM (1995) Blue light-emitting diode built-in contact lens electrode can record human S-cone electroretinogram. Invest Ophthalmol Vis Sci 36:1730–1732PubMed
18.
Zurück zum Zitat Simonsen SE, Rosenberg T (1995–1996) Reappraisal of a short-wavelength-sensitive (S-cone) recording technique in routine clinical electroretinography. Doc Ophthalmol 91:323–332 Simonsen SE, Rosenberg T (1995–1996) Reappraisal of a short-wavelength-sensitive (S-cone) recording technique in routine clinical electroretinography. Doc Ophthalmol 91:323–332
19.
Zurück zum Zitat Maeda H, Nakamura M, Negi A (2001) Selective reduction of the S-cone component of the electroretinogram in Posner–Schlossman syndrome. Eye (Lond) 15:163–167CrossRef Maeda H, Nakamura M, Negi A (2001) Selective reduction of the S-cone component of the electroretinogram in Posner–Schlossman syndrome. Eye (Lond) 15:163–167CrossRef
20.
Zurück zum Zitat Chiti Z, North RV, Mortlock KE, Drasdo N (2003) The S-cone electroretinogram: a comparison of techniques, normative data and age-related variation. Ophthalmic Physiol Opt 23:370–376CrossRef Chiti Z, North RV, Mortlock KE, Drasdo N (2003) The S-cone electroretinogram: a comparison of techniques, normative data and age-related variation. Ophthalmic Physiol Opt 23:370–376CrossRef
21.
Zurück zum Zitat Marmor MF, Cabael L, Shukla S, Hwang JC, Marcus M (2004) Clinical S-cone ERG recording with a commercial hand-held full-field stimulator. Doc Ophthalmol 109:101–107CrossRef Marmor MF, Cabael L, Shukla S, Hwang JC, Marcus M (2004) Clinical S-cone ERG recording with a commercial hand-held full-field stimulator. Doc Ophthalmol 109:101–107CrossRef
22.
Zurück zum Zitat Tsuruoka M, Yamamoto S, Ogata K, Hayashi M (2004) Built-in LED contact lens electrode for S-cone electroretinographic recordings. Doc Ophthalmol 108:61–66CrossRef Tsuruoka M, Yamamoto S, Ogata K, Hayashi M (2004) Built-in LED contact lens electrode for S-cone electroretinographic recordings. Doc Ophthalmol 108:61–66CrossRef
23.
Zurück zum Zitat Sustar M, Hawlina M, Brecelj J (2011) Electroretinographic evaluation of the retinal S-cone system. Doc Ophthalmol 123:199–210CrossRef Sustar M, Hawlina M, Brecelj J (2011) Electroretinographic evaluation of the retinal S-cone system. Doc Ophthalmol 123:199–210CrossRef
24.
Zurück zum Zitat Rocha-Sousa A, Hayashi T, Gomes NL, Penas S, Brandao E, Rocha P, Urashima M, Yamada H, Tsuneoka H, Falcao-Reis F (2011) A novel mutation (Cy83Tyr) in the second zinc finger of NR2E3 in enhanced C-cones syndrome. Gaefes Arch Clin Exp Ophthalmol 249:201–208CrossRef Rocha-Sousa A, Hayashi T, Gomes NL, Penas S, Brandao E, Rocha P, Urashima M, Yamada H, Tsuneoka H, Falcao-Reis F (2011) A novel mutation (Cy83Tyr) in the second zinc finger of NR2E3 in enhanced C-cones syndrome. Gaefes Arch Clin Exp Ophthalmol 249:201–208CrossRef
25.
Zurück zum Zitat Cima I, Brecelj J, Sustar M, Coppieters F, Leroy BP, De Baere E, Hawlina M (2012) Enhanced S-cone syndrome with preserved macular structure and severely depressed retinal function. Doc Ophthalmol 125:161–168CrossRef Cima I, Brecelj J, Sustar M, Coppieters F, Leroy BP, De Baere E, Hawlina M (2012) Enhanced S-cone syndrome with preserved macular structure and severely depressed retinal function. Doc Ophthalmol 125:161–168CrossRef
26.
Zurück zum Zitat Schatz A, Dominik Fischer M, Schommer K, Zrenner E, Bartz-Schmidt KU, Gekeler F, Willmann G (2014) Attenuation of S-cone function at high altitude assessed by electroretinography. Vis Res 97:59–64CrossRef Schatz A, Dominik Fischer M, Schommer K, Zrenner E, Bartz-Schmidt KU, Gekeler F, Willmann G (2014) Attenuation of S-cone function at high altitude assessed by electroretinography. Vis Res 97:59–64CrossRef
27.
Zurück zum Zitat Campi I, Cammarata G, Bianchi Marzoli S, Beck-Peccoz P, Santarsiero D, Dazzi D, Bottari de Castello A, Taroni EG, Viola F, Mian C, Watutantrige-Fernando S, Pelusi C, Muzza M, Maffini MA, Persani L (2017) Retinal photoreceptor functions are compromised in patients with resistance to thyroid hormone syndrome (RTHβ). J Clin Endocrinol Metab 102:2620–2627CrossRef Campi I, Cammarata G, Bianchi Marzoli S, Beck-Peccoz P, Santarsiero D, Dazzi D, Bottari de Castello A, Taroni EG, Viola F, Mian C, Watutantrige-Fernando S, Pelusi C, Muzza M, Maffini MA, Persani L (2017) Retinal photoreceptor functions are compromised in patients with resistance to thyroid hormone syndrome (RTHβ). J Clin Endocrinol Metab 102:2620–2627CrossRef
Metadaten
Titel
ISCEV extended protocol for the S-cone ERG
verfasst von
Ido Perlman
Mineo Kondo
Enid Chelva
Anthony G. Robson
Graham E. Holder
Publikationsdatum
20.11.2019
Verlag
Springer Berlin Heidelberg
Erschienen in
Documenta Ophthalmologica / Ausgabe 2/2020
Print ISSN: 0012-4486
Elektronische ISSN: 1573-2622
DOI
https://doi.org/10.1007/s10633-019-09730-6

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