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01.09.2009 | Review | Ausgabe 5/2009

Basic Research in Cardiology 5/2009

Ischemic postconditioning: experimental models and protocol algorithms

Zeitschrift:
Basic Research in Cardiology > Ausgabe 5/2009
Autoren:
Andreas Skyschally, Patrick van Caster, Efstathios K. Iliodromitis, Rainer Schulz, Dimitrios T. Kremastinos, Gerd Heusch
Wichtige Hinweise
J. M. Downey, Mobile, USA served as guest editor for the manuscript and was responsible for all editorial decisions, including the selection of reviewers. The policy applies to all manuscripts with authors from the editor’s institution.

Abstract

Ischemic postconditioning, a simple mechanical maneuver at the onset of reperfusion, reduces infarct size after ischemia/reperfusion. After its first description in 2003 by Zhao et al. numerous experimental studies have investigated this protective phenomenon. Whereas the underlying mechanisms and signal transduction are not yet understood in detail, infarct size reduction by ischemic postconditioning was confirmed in all species tested so far, including man. We have now reviewed the literature with focus on experimental models and protocols to better understand the determinants of protection by ischemic postconditioning or lack of it. Only studies with infarct size as unequivocal endpoint were considered. In all species and models, the duration of index ischemia and the protective protocol algorithm impact on the outcome of ischemic postconditioning, and gender, age, and myocardial temperature contribute.

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