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Erschienen in: Graefe's Archive for Clinical and Experimental Ophthalmology 2/2021

09.09.2020 | Trauma

Isolated-check visual evoked potential: a more sensitive tool to detect traumatic optic neuropathy after orbital fracture

verfasst von: Yanjie Tian, Yinhao Wang, Ziyuan Liu, Xuemin Li

Erschienen in: Graefe's Archive for Clinical and Experimental Ophthalmology | Ausgabe 2/2021

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Abstract

Purpose

To establish a more sensitive diagnostic tool for traumatic optic neuropathy (TON), we explored the diagnostic efficacy of isolated-check visual evoked potential (ic-VEP) for TON in orbital fracture and compared ic-VEP with pattern-reversal visual evoked potential (P-VEP) testing.

Methods

This was a prospective single-center study. A total of 137 eyes from 131 patients diagnosed between December 2016 and October 2019 with orbital fractures were included in the study. Injury history, best-corrected visual acuity (BCVA), visual field, computed tomography (CT), P-VEP, and ic-VEP data were collected. Parameters of ic-VEP (signal-to-noise ratio [SNR]) and P-VEP (peak latency and amplitude of P100) were compared and diagnostic accuracy was analyzed.

Results

TON was associated with worse BCVA than non-TON (median 0.52 versus 0.10 logMAR, P < 0.001). SNRs were negatively associated with the P100 peak latency while positively associated with the P100 amplitude. The sensitivity of ic-VEP for TON (79.6%) was higher than that of P-VEP (61.2%, P = 0.049), although this difference was not statistically significant after Bonferroni correction. Using ic-VEP and P-VEP together could increase sensitivity (87.8%). Maximum areas under curve were obtained using the SNR criteria of 1.3, 1.47, and 1.54 at 8%, 16%, and 32% depth of modulation, respectively.

Conclusion

ic-VEP was more sensitive than P-VEP in diagnosing TON, and a combination of the two examination tests was recommended. The use of ic-VEP as the new diagnostic standard technique for TON should be considered.
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Literatur
6.
Zurück zum Zitat Linberg JV (1987) Orbital compartment syndromes following trauma. Adv Ophthalmic Plast Reconstr Surg 6:51–62PubMed Linberg JV (1987) Orbital compartment syndromes following trauma. Adv Ophthalmic Plast Reconstr Surg 6:51–62PubMed
8.
Zurück zum Zitat Kashkouli MB, Yousefi S, Nojomi M, Sanjari MS, Pakdel F, Entezari M, Etezad-Razavi M, Razeghinejad MR, Esmaeli M, Shafiee M, Bagheri M (2018) Traumatic optic neuropathy treatment trial (TONTT): open label, phase 3, multicenter, semi-experimental trial. Graefes Arch Clin Exp Ophthalmol 256(1):209–218. https://doi.org/10.1007/s00417-017-3816-5CrossRefPubMed Kashkouli MB, Yousefi S, Nojomi M, Sanjari MS, Pakdel F, Entezari M, Etezad-Razavi M, Razeghinejad MR, Esmaeli M, Shafiee M, Bagheri M (2018) Traumatic optic neuropathy treatment trial (TONTT): open label, phase 3, multicenter, semi-experimental trial. Graefes Arch Clin Exp Ophthalmol 256(1):209–218. https://​doi.​org/​10.​1007/​s00417-017-3816-5CrossRefPubMed
11.
Zurück zum Zitat Merigan WH, Maunsell JH (1993) How parallel are the primate visual pathways? Annual Reviews Inc 16:369–402 Merigan WH, Maunsell JH (1993) How parallel are the primate visual pathways? Annual Reviews Inc 16:369–402
19.
Zurück zum Zitat Weber AJ, Chen H, Hubbard WC, Kaufman PL (2000) Experimental glaucoma and cell size, density, and number in the primate lateral geniculate nucleus. Invest Ophthalmol Vis Sci 41(6):1370–1379PubMed Weber AJ, Chen H, Hubbard WC, Kaufman PL (2000) Experimental glaucoma and cell size, density, and number in the primate lateral geniculate nucleus. Invest Ophthalmol Vis Sci 41(6):1370–1379PubMed
21.
Zurück zum Zitat Zemon V, Tsai JC, Forbes M, Al-Aswad LA, Chen CM, Gordon J, Greenstein VC, Hu G, Strugstad EC, Dhrami-Gavazi E, Jindra LF (2008) Novel electrophysiological instrument for rapid and objective assessment of magnocellular deficits associated with glaucoma. Doc Ophthalmol 117(3):233–243. https://doi.org/10.1007/s10633-008-9129-6CrossRefPubMed Zemon V, Tsai JC, Forbes M, Al-Aswad LA, Chen CM, Gordon J, Greenstein VC, Hu G, Strugstad EC, Dhrami-Gavazi E, Jindra LF (2008) Novel electrophysiological instrument for rapid and objective assessment of magnocellular deficits associated with glaucoma. Doc Ophthalmol 117(3):233–243. https://​doi.​org/​10.​1007/​s10633-008-9129-6CrossRefPubMed
27.
Zurück zum Zitat Glovinsky Y, Quigley HA, Pease ME (1993) Foveal ganglion cell loss is size dependent in experimental glaucoma. Invest Ophthalmol Vis Sci 34(2):395–400PubMed Glovinsky Y, Quigley HA, Pease ME (1993) Foveal ganglion cell loss is size dependent in experimental glaucoma. Invest Ophthalmol Vis Sci 34(2):395–400PubMed
Metadaten
Titel
Isolated-check visual evoked potential: a more sensitive tool to detect traumatic optic neuropathy after orbital fracture
verfasst von
Yanjie Tian
Yinhao Wang
Ziyuan Liu
Xuemin Li
Publikationsdatum
09.09.2020
Verlag
Springer Berlin Heidelberg
Erschienen in
Graefe's Archive for Clinical and Experimental Ophthalmology / Ausgabe 2/2021
Print ISSN: 0721-832X
Elektronische ISSN: 1435-702X
DOI
https://doi.org/10.1007/s00417-020-04895-2

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