Erschienen in:
21.11.2018 | Melanoma
Isolated Limb Infusion and Isolated Limb Perfusion for Melanoma: Can the Outcomes of these Procedures be Compared?
verfasst von:
Hidde M. Kroon, MD, PhD, John F. Thompson, MD, FRACS, FACS
Erschienen in:
Annals of Surgical Oncology
|
Ausgabe 1/2019
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Excerpt
When bulky or numerous local melanoma recurrences or in-transit melanoma metastases develop in a limb, simple local treatment modalities such as excision, cryotherapy, laser ablation, or intralesional injection with Rose Bengal (PV-10) or talimogene laherparepvec (T-VEC) are likely to be ineffective or simply not possible.
1 However, achieving adequate disease control is important in these patients as the metastatic lesions frequently cause troublesome symptoms such as pain and ulceration with oozing, odor, and hemorrhage, sometimes accompanied by restricted mobility and social isolation.
2 Moreover, those who develop extensive recurrent disease are often elderly, many of them physically frail and suffering from multiple comorbidities.
2 Treatment of these patients is therefore aimed at achieving effective disease control and, most importantly, limb preservation, using a treatment with limited locoregional toxicity that is unlikely to cause serious systemic side effects. …
