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21.04.2016 | Original Article

Isolation and genetic characterization of novel reassortant H6N6 subtype avian influenza viruses isolated from chickens in eastern China

verfasst von: Haibo Wu, Rufeng Lu, Xiuming Peng, Xiaorong Peng, Linfang Cheng, Changzhong Jin, Xiangyun Lu, Tiansheng Xie, Hangping Yao, Nanping Wu

Erschienen in: Archives of Virology | Ausgabe 7/2016

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Abstract

H6 subtype avian influenza viruses (AIVs) possess the ability to cross the species barrier to infect mammals and pose a threat to human health. From June 2014 to July 2015, 12 H6N6 AIVs were isolated from chickens in live-poultry markets in Zhejiang Province, Eastern China. Phylogenetic analysis showed that these isolates received their genes from H6 and H9N2 subtype AIVs of poultry in China. These novel reassortant viruses showed moderate pathogenicity in mice and were able to replicate in mice without prior adaptation. Considering that novel reassorted H6N6 viruses were isolated from chickens in this study, it is possible that these chickens play an important role in the generation of novel reassorted H6N6 AIVs, and these results emphasize the need for continued surveillance of the H6N6 AIVs circulating in poultry.

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Webster RG, Bean WJ, Gorman OT, Chambers TM, Kawaoka Y (1992) Evolution and ecology of influenza A viruses. Microbiol Rev 56:152–179PubMedPubMedCentral

Liu M, He S, Walker D, Zhou N, Perez DR, Mo B, Li F, Huang X, Webster RG, Webby RJ (2003) The influenza virus gene pool in a poultry market in South central china. Virology 305:267–275CrossRefPubMed

Cardona C, Yee K, Carpenter T (2009) Are live bird markets reservoirs of avian influenza? Poult Sci 88:856–859CrossRefPubMed

Chen Y, Liang W, Yang S, Wu N, Gao H, Sheng J, Yao H, Wo J, Fang Q, Cui D, Li Y, Yao X, Zhang Y, Wu H, Zheng S, Diao H, Xia S, Chan KH, Tsoi HW, Teng JL, Song W, Wang P, Lau SY, Zheng M, Chan JF, To KK, Chen H, Li L, Yuen KY (2013) Human infections with the emerging avian influenza A H7N9 virus from wet market poultry: clinical analysis and characterisation of viral genome. Lancet 381:1916–1925CrossRefPubMed

Gao R, Cao B, Hu Y, Feng Z, Wang D, Hu W, Chen J, Jie Z, Qiu H, Xu K, Xu X, Lu H, Zhu W, Gao Z, Xiang N, Shen Y, He Z, Gu Y, Zhang Z, Yang Y, Zhao X, Zhou L, Li X, Zou S, Zhang Y, Yang L, Guo J, Dong J, Li Q, Dong L, Zhu Y, Bai T, Wang S, Hao P, Yang W, Han J, Yu H, Li D, Gao GF, Wu G, Wang Y, Yuan Z, Shu Y (2013) Human infection with a novel avian-origin influenza A (H7N9) virus. N Engl J Med 368:1888–1897CrossRefPubMed

Guan Y, Farooqui A, Zhu H, Dong W, Wang J, Kelvin DJ (2013) H7N9 Incident, immune status, the elderly and a warning of an influenza pandemic. J Infect Dev Ctries 7:302–307CrossRefPubMed

Munster VJ, Baas C, Lexmond P, Waldenstrom J, Wallensten A, Fransson T, Rimmelzwaan GF, Beyer WE, Schutten M, Olsen B, Osterhaus AD, Fouchier RA (2007) Spatial, temporal, and species variation in prevalence of influenza A viruses in wild migratory birds. PLoS Pathog 3:e61CrossRefPubMedPubMedCentral

Krauss S, Obert CA, Franks J, Walker D, Jones K, Seiler P, Niles L, Pryor SP, Obenauer JC, Naeve CW, Widjaja L, Webby RJ, Webster RG (2007) Influenza in migratory birds and evidence of limited intercontinental virus exchange. PLoS Pathog 3:e167CrossRefPubMedPubMedCentral

Krauss S, Walker D, Pryor SP, Niles L, Chenghong L, Hinshaw VS, Webster RG (2004) Influenza A viruses of migrating wild aquatic birds in North America. Vector Borne Zoonotic Dis 4:177–189CrossRefPubMed

10.

Kim HR, Lee YJ, Lee KK, Oem JK, Kim SH, Lee MH, Lee OS, Park CK (2010) Genetic relatedness of H6 subtype avian influenza viruses isolated from wild birds and domestic ducks in Korea and their pathogenicity in animals. J Gen Virol 91:208–219CrossRefPubMed

11.

Nam JH, Kim EH, Song D, Choi YK, Kim JK, Poo H (2011) Emergence of mammalian species-infectious and -pathogenic avian influenza H6N5 virus with no evidence of adaptation. J Virol 85:13271–13277CrossRefPubMedPubMedCentral

12.

Huang K, Zhu H, Fan X, Wang J, Cheung CL, Duan L, Hong W, Liu Y, Li L, Smith DK, Chen H, Webster RG, Webby RJ, Peiris M, Guan Y (2012) Establishment and lineage replacement of H6 influenza viruses in domestic ducks in southern China. J Virol 86:6075–6083CrossRefPubMedPubMedCentral

13.

Zhao G, Lu X, Gu X, Zhao K, Song Q, Pan J, Xu Q, Duan Z, Peng D, Hu S, Wang X, Liu X (2011) Molecular evolution of the H6 subtype influenza A viruses from poultry in eastern China from 2002 to 2010. Virol J 8:470CrossRefPubMedPubMedCentral

14.

Wang G, Deng G, Shi J, Luo W, Zhang G, Zhang Q, Liu L, Jiang Y, Li C, Sriwilaijaroen N, Hiramatsu H, Suzuki Y, Kawaoka Y, Chen H (2014) H6 influenza viruses pose a potential threat to human health. J Virol 88:3953–3964CrossRefPubMedPubMedCentral

15.

Chin PS, Hoffmann E, Webby R, Webster RG, Guan Y, Peiris M, Shortridge KF (2002) Molecular evolution of H6 influenza viruses from poultry in Southeastern China: prevalence of H6N1 influenza viruses possessing seven A/Hong Kong/156/97 (H5N1)-like genes in poultry. J Virol 76:507–516CrossRefPubMedPubMedCentral

16.

Wu H, Peng X, Cheng L, Wu N (2015) Molecular characterization of novel reassortant H6N2 subtype avian influenza viruses isolated from poultry in Eastern China, in 2014. Infect Genet Evol 36:41–45CrossRefPubMed

17.

Abolnik C, Bisschop S, Gerdes T, Olivier A, Horner R (2007) Outbreaks of avian influenza H6N2 viruses in chickens arose by a reassortment of H6N8 and H9N2 ostrich viruses. Virus Genes 34:37–45CrossRefPubMed

18.

Corrand L, Delverdier M, Lucas MN, Croville G, Facon C, Balloy D, Ducatez M, Guerin JL (2012) A low-pathogenic avian influenza H6N1 outbreak in a turkey flock in France: a comprehensive case report. Avian Pathol 41:569–577CrossRefPubMed

19.

Zhang G, Kong W, Qi W, Long LP, Cao Z, Huang L, Qi H, Cao N, Wang W, Zhao F, Ning Z, Liao M, Wan XF (2011) Identification of an H6N6 swine influenza virus in southern China. Infect Genet Evol 11:1174–1177CrossRefPubMedPubMedCentral

20.

Myers KP, Setterquist SF, Capuano AW, Gray GC (2007) Infection due to 3 avian influenza subtypes in United States veterinarians. Clin Infect Dis 45:4–9CrossRefPubMedPubMedCentral

21.

Wei SH, Yang JR, Wu HS, Chang MC, Lin JS, Lin CY, Liu YL, Lo YC, Yang CH, Chuang JH, Lin MC, Chung WC, Liao CH, Lee MS, Huang WT, Chen PJ, Liu MT, Chang FY (2013) Human infection with avian influenza A H6N1 virus: an epidemiological analysis. Lancet Respir Med 1:771–778CrossRefPubMed

22.

Kayali G, Ortiz EJ, Chorazy ML, Gray GC (2010) Evidence of previous avian influenza infection among US turkey workers. Zoonoses Public Health 57:265–272CrossRefPubMed

23.

Wang F, Qi J, Bi Y, Zhang W, Wang M, Zhang B, Liu J, Yan J, Shi Y, Gao GF (2015) Adaptation of avian influenza A (H6N1) virus from avian to human receptor-binding preference. EMBO J 34(12):1661–1673CrossRefPubMedPubMedCentral

24.

Cheng K, Yu Z, Gao Y, Xia X, He H, Hua Y, Chai H (2014) Experimental infection of dogs with H6N1 avian influenza A virus. Arch Virol 159:2275–2282CrossRefPubMed

25.

Huang K, Bahl J, Fan XH, Vijaykrishna D, Cheung CL, Webby RJ, Webster RG, Chen H, Smith GJ, Peiris JS, Guan Y (2010) Establishment of an H6N2 influenza virus lineage in domestic ducks in southern China. J Virol 84:6978–6986CrossRefPubMedPubMedCentral

26.

Ozaki H, Guan Y, Peiris M, Webster R, Webby R (2011) Changing patterns of h6 influenza viruses in Hong Kong poultry markets. Influenza Res Treat 2011:702092PubMed

27.

WHO (2014) WHO China statement on H5N6. http://www.wpro.who.int/china/mediacentre/releases/2014/20140507/en/. Accessed 2 Nov 2015

28.

Bi Y, Mei K, Shi W, Liu D, Yu X, Gao Z, Zhao L, Gao GF, Chen J, Chen Q (2015) Two novel reassortants of avian influenza A (H5N6) virus in China. J Gen Virol 96(Pt 5):975–981CrossRefPubMed

29.

Wu HB, Guo CT, Lu RF, Xu LH, Wo EK, You JB, Wang YT, Wang QG, Wu NP (2012) Genetic characterization of subtype H1 avian influenza viruses isolated from live poultry markets in Zhejiang Province, China, in 2011. Virus Genes 44:441–449CrossRefPubMed

30.

Chen J, Yang Z, Chen Q, Liu X, Fang F, Chang H, Li D, Chen Z (2009) Characterization of H5N1 influenza A viruses isolated from domestic green-winged teal. Virus Genes 38:66–73CrossRefPubMed

31.

Hoffmann E, Stech J, Guan Y, Webster RG, Perez DR (2001) Universal primer set for the full-length amplification of all influenza A viruses. Arch Virol 146:2275–2289CrossRefPubMed

32.

Tamura K, Stecher G, Peterson D, Filipski A, Kumar S (2013) MEGA6: molecular evolutionary genetics analysis version 6.0. Mol Biol Evol 30:2725–2729CrossRefPubMedPubMedCentral

33.

Wong FY, Phommachanh P, Kalpravidh W, Chanthavisouk C, Gilbert J, Bingham J, Davies KR, Cooke J, Eagles D, Phiphakhavong S, Shan S, Stevens V, Williams DT, Bounma P, Khambounheuang B, Morrissy C, Douangngeun B, Morzaria S (2015) Reassortant highly pathogenic influenza A(H5N6) virus in Laos. Emerg Infect Dis 21:511–516CrossRefPubMedPubMedCentral

34.

Reed L, Muench H (1938) A simple method for estimating fifty percent endpoints. Am J Hyg 27:493–497

35.

Hai-bo W, Chao-tan G, Ru-feng L, Li-hua X, En-kang W, Jin-biao Y, Yi-ting W, Qiao-gang W, Nan-ping W (2012) Characterization of a highly pathogenic H5N1 avian influenza virus isolated from ducks in Eastern China in 2011. Arch Virol 157:1131–1136CrossRefPubMed

36.

Klimov A, Balish A, Veguilla V, Sun H, Schiffer J, Lu X, Katz JM, Hancock K (2012) Influenza virus titration, antigenic characterization, and serological methods for antibody detection. Methods Mol Biol 865:25–51CrossRefPubMed

37.

Pearson JEOIdE (2003) International standards for the control of avian influenza. Avian Dis 47(3 Suppl):972–975CrossRefPubMed

38.

Wu H, Lu R, Peng X, Xu L, Cheng L, Lu X, Jin C, Xie T, Yao H, Wu N (2015) Novel reassortant highly pathogenic H5N6 avian influenza viruses in poultry in China. Infect Genet Evol 31:64–67CrossRefPubMed

39.

Matrosovich MN, Gambaryan AS, Teneberg S, Piskarev VE, Yamnikova SS, Lvov DK, Robertson JS, Karlsson KA (1997) Avian influenza A viruses differ from human viruses by recognition of sialyloligosaccharides and gangliosides and by a higher conservation of the HA receptor-binding site. Virology 233:224–234CrossRefPubMed

40.

Chen Z, Zhou H, Kim L, Jin H (2012) The receptor binding specificity of the live attenuated influenza H2 and H6 vaccine viruses contributes to vaccine immunogenicity and protection in ferrets. J Virol 86:2780–2786CrossRefPubMedPubMedCentral

41.

Tzarum N, de Vries RP, Zhu X, Yu W, McBride R, Paulson JC, Wilson IA (2015) Structure and receptor binding of the hemagglutinin from a human H6N1 influenza virus. Cell Host Microbe 17:369–376CrossRefPubMedPubMedCentral

42.

Ni F, Kondrashkina E, Wang Q (2015) Structural and functional studies of influenza virus A/H6 hemagglutinin. PLoS One 10:e0134576CrossRefPubMedPubMedCentral

43.

Zhang Y, Zhu J, Li Y, Bradley KC, Cao J, Chen H, Jin M, Zhou H (2013) Glycosylation on hemagglutinin affects the virulence and pathogenicity of pandemic H1N1/2009 influenza A virus in mice. PLoS One 8:e61397CrossRefPubMedPubMedCentral

44.

Iqbal M, Essen SC, Xiao H, Brookes SM, Brown IH, McCauley JW (2012) Selection of variant viruses during replication and transmission of H7N1 viruses in chickens and turkeys. Virology 433:282–295CrossRefPubMed

45.

Helenius A, Aebi M (2004) Roles of N-linked glycans in the endoplasmic reticulum. Annu Rev Biochem 73:1019–1049CrossRefPubMed

46.

Aoki FY, Boivin G, Roberts N (2007) Influenza virus susceptibility and resistance to oseltamivir. Antivir Ther 12:603–616PubMed

47.

Saito R, Sakai T, Sato I, Sano Y, Oshitani H, Sato M, Suzuki H (2003) Frequency of amantadine-resistant influenza A viruses during two seasons featuring cocirculation of H1N1 and H3N2. J Clin Microbiol 41:2164–2165CrossRefPubMedPubMedCentral

48.

Schat KA, Bingham J, Butler JM, Chen LM, Lowther S, Crowley TM, Moore RJ, Donis RO, Lowenthal JW (2012) Role of position 627 of PB2 and the multibasic cleavage site of the hemagglutinin in the virulence of H5N1 avian influenza virus in chickens and ducks. PLoS One 7:e30960CrossRefPubMedPubMedCentral

49.

Zhou B, Li Y, Halpin R, Hine E, Spiro DJ, Wentworth DE (2011) PB2 residue 158 is a pathogenic determinant of pandemic H1N1 and H5 influenza a viruses in mice. J Virol 85:357–365CrossRefPubMed

50.

Bussey KA, Bousse TL, Desmet EA, Kim B, Takimoto T (2010) PB2 residue 271 plays a key role in enhanced polymerase activity of influenza A viruses in mammalian host cells. J Virol 84:4395–4406CrossRefPubMedPubMedCentral

51.

Steel J, Lowen AC, Mubareka S, Palese P (2009) Transmission of influenza virus in a mammalian host is increased by PB2 amino acids 627K or 627E/701N. PLoS Pathog 5:e1000252CrossRefPubMedPubMedCentral

52.

Tan L, Su S, Smith DK, He S, Zheng Y, Shao Z, Ma J, Zhu H, Zhang G (2014) A combination of HA and PA mutations enhances virulence in a mouse-adapted H6N6 influenza A virus. J Virol 88:14116–14125CrossRefPubMedPubMedCentral

53.

Zhu Q, Yang H, Chen W, Cao W, Zhong G, Jiao P, Deng G, Yu K, Yang C, Bu Z, Kawaoka Y, Chen H (2008) A naturally occurring deletion in its NS gene contributes to the attenuation of an H5N1 swine influenza virus in chickens. J Virol 82:220–228CrossRefPubMed

54.

Jiao P, Tian G, Li Y, Deng G, Jiang Y, Liu C, Liu W, Bu Z, Kawaoka Y, Chen H (2008) A single-amino-acid substitution in the NS1 protein changes the pathogenicity of H5N1 avian influenza viruses in mice. J Virol 82:1146–1154CrossRefPubMed

55.

Montomoli E, Maria TC (2014) Is influenza A/H10N8 a potential candidate for the next pandemic? Pathog Glob Health 108:213CrossRefPubMedPubMedCentral

56.

Hotta K, Takakuwa H, Le QM, Phuong SL, Murase T, Ono E, Ito T, Otsuki K, Yamashiro T (2012) Isolation and characterization of H6N1 and H9N2 avian influenza viruses from Ducks in Hanoi, Vietnam. Virus Res 163:448–453CrossRefPubMed

57.

Fan Z, Ci Y, Ma Y, Liu L, Wang D, Ma J, Li Y, Chen H (2014) Phylogenetic analysis of a novel H6N6 avian influenza virus isolated from a green peafowl in China and its pathogenic potential in mice. Infect Genet Evol 28:107–112CrossRefPubMed

58.

Hoffmann E, Stech J, Leneva I, Krauss S, Scholtissek C, Chin PS, Peiris M, Shortridge KF, Webster RG (2000) Characterization of the influenza A virus gene pool in avian species in southern China: was H6N1 a derivative or a precursor of H5N1? J Virol 74:6309–6315CrossRefPubMedPubMedCentral

59.

Shi W, Shi Y, Wu Y, Liu D, Gao GF (2013) Origin and molecular characterization of the human-infecting H6N1 influenza virus in Taiwan. Protein Cell 4:846–853CrossRefPubMedPubMedCentral

60.

Guo YJ, Krauss S, Senne DA, Mo IP, Lo KS, Xiong XP, Norwood M, Shortridge KF, Webster RG, Guan Y (2000) Characterization of the pathogenicity of members of the newly established H9N2 influenza virus lineages in Asia. Virology 267:279–288CrossRefPubMed

61.

Lee YJ, Shin JY, Song MS, Lee YM, Choi JG, Lee EK, Jeong OM, Sung HW, Kim JH, Kwon YK, Kwon JH, Kim CJ, Webby RJ, Webster RG, Choi YK (2007) Continuing evolution of H9 influenza viruses in Korean poultry. Virology 359:313–323CrossRefPubMed

62.

Biswas PK, Christensen JP, Ahmed SS, Barua H, Das A, Rahman MH, Giasuddin M, Hannan AS, Habib MA, Ahad A, Rahman AS, Faruque R, Debnath NC (2008) Avian influenza outbreaks in chickens, Bangladesh. Emerg Infect Dis 14:1909–1912CrossRefPubMedPubMedCentral

63.

Wu H, Wu N, Peng X, Jin C, Lu X, Cheng L, Yao H, Li L (2014) Molecular characterization and phylogenetic analysis of H3 subtype avian influenza viruses isolated from domestic ducks in Zhejiang Province in China. Virus Genes 49:80–88CrossRefPubMed

64.

Suarez DL (2000) Evolution of avian influenza viruses. Vet Microbiol 74:15–27CrossRefPubMed

65.

Zhang P, Tang Y, Liu X, Liu W, Zhang X, Liu H, Peng D, Gao S, Wu Y, Zhang L, Lu S (2009) A novel genotype H9N2 influenza virus possessing human H5N1 internal genomes has been circulating in poultry in eastern China since 1998. J Virol 83:8428–8438CrossRefPubMedPubMedCentral

66.

Tombari W, Paul M, Bettaieb J, Larbi I, Nsiri J, Elbehi I, Gribaa L, Ghram A (2013) Risk factors and characteristics of low pathogenic avian influenza virus isolated from commercial poultry in Tunisia. PLoS One 8:e53524CrossRefPubMedPubMedCentral

67.

Belser JA, Gustin KM, Pearce MB, Maines TR, Zeng H, Pappas C, Sun X, Carney PJ, Villanueva JM, Stevens J, Katz JM, Tumpey TM (2013) Pathogenesis and transmission of avian influenza A (H7N9) virus in ferrets and mice. Nature 501:556–559CrossRefPubMed

68.

Brown EG (1990) Increased virulence of a mouse-adapted variant of influenza A/FM/1/47 virus is controlled by mutations in genome segments 4, 5, 7, and 8. J Virol 64:4523–4533PubMedPubMedCentral

69.

Gillim-Ross L, Santos C, Chen Z, Aspelund A, Yang CF, Ye D, Jin H, Kemble G, Subbarao K (2008) Avian influenza h6 viruses productively infect and cause illness in mice and ferrets. J Virol 82:10854–10863CrossRefPubMedPubMedCentral

70.

Yao Y, Wang H, Chen Q, Zhang H, Zhang T, Chen J, Xu B, Sun B, Chen Z (2013) Characterization of low-pathogenic H6N6 avian influenza viruses in central China. Arch Virol 158:367–377CrossRefPubMed

Titel: Isolation and genetic characterization of novel reassortant H6N6 subtype avian influenza viruses isolated from chickens in eastern China
verfasst von: Haibo Wu
Rufeng Lu
Xiuming Peng
Xiaorong Peng
Linfang Cheng
Changzhong Jin
Xiangyun Lu
Tiansheng Xie
Hangping Yao
Nanping Wu
Publikationsdatum: 21.04.2016
Verlag: Springer Vienna
Erschienen in: Archives of Virology / Ausgabe 7/2016
Print ISSN: 0304-8608
Elektronische ISSN: 1432-8798
DOI: https://doi.org/10.1007/s00705-016-2861-4

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Isolation and genetic characterization of novel reassortant H6N6 subtype avian influenza viruses isolated from chickens in eastern China

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