Skip to main content
Erschienen in: Inflammopharmacology 2/2024

09.02.2024 | Original Article

Isolation, invitro, invivo anti-inflammatory, analgesic and antioxidant potential of Habenaria plantegania Lindl

verfasst von: Osama M. Alshehri, Madeeha Shabnam, Saeed Ahmed Asiri, Mater H. Mahnashi, Abdul Sadiq, Muhammad Saeed Jan

Erschienen in: Inflammopharmacology | Ausgabe 2/2024

Einloggen, um Zugang zu erhalten

Abstract

Habenaira plantaginea belong to orchid family which is native to Asia. Members of this family are commonly famous for the cure of pain and inflammation. To date, no research was found on isolation of compounds from this plant for the treatment of inflammation and analgesia nor has been published to our knowledge. The purpose of this study was to evaluate an analgesic, anti-inflammatory and anti-oxidant activity of the isolated compound from the most potent chloroform sub-fraction and the isolated compounds form the habenaria plantaginea. Anti-inflammatory analgesic and antioxidant potential of the various chloroform sub-fractions and isolated compounds from the most potent sub-fraction (HP-1 & HP-1) were screened for their in vitro enzymatic assays. Furthermore, prior to in-vivo investigation, the isolated compounds were subjected for their toxicity study. The potent compound was then examined for acetic acid-induced writhing, hot plate test, carrageenan-induced inflammation assays. Further various phlogistic agents were used for the evaluation of mechanism. In the COX-2 inhibitory assay the chloroform sub fraction Cf-4 demonstrated excellent activity as compared to the other sub-fraction with 92.15% inhibition. The COX-2 enzyme make prostaglandins which are directly involved in inflammation. Likewise against 5-LOX the Cf-4 was the most potent sub-fraction with IC50 3.77 µg/mL. The 5-LOX catalyzes the biosynthesis of leukotrienes which is a group of lipid mediators of inflammation derived from arachidonic acid. Free radicals can induce inflammation through cellular damage while chronic inflammation generates a large number of free radicals, whose eventually lead to inflammation. In antioxidant assays the Cf-4 fraction was displayed excellent results against ABTS, DPPH and H2O2 free radical with 88.88, 77.44, and 65.52% inhibition at highest concentration. Likewise, the compound HP-1 demonstrated 88.81, 89.34 and 80.43% inhibition while compound HP-2 displayed 84.34, 91.52 and 82.34% inhibition against ABTS, DPPH and H2O2 free radical which were comparable to the standard drug ascorbic acid respectively. This study's findings validate the use of this species as traditional use.
Anhänge
Nur mit Berechtigung zugänglich
Literatur
Zurück zum Zitat Abubakar I et al (2018) The UCL–Lancet Commission on Migration and Health: the health of a world on the move. The Lancet 392(10164):2606–2654CrossRef Abubakar I et al (2018) The UCL–Lancet Commission on Migration and Health: the health of a world on the move. The Lancet 392(10164):2606–2654CrossRef
Zurück zum Zitat Ahmad A et al (2019) Pharmacological evaluation of aldehydic-pyrrolidinedione against HCT-116, MDA-MB231, NIH/3T3, MCF-7 cancer cell lines, antioxidant and enzyme inhibition studies. Drug Des Dev Ther 13:4185CrossRef Ahmad A et al (2019) Pharmacological evaluation of aldehydic-pyrrolidinedione against HCT-116, MDA-MB231, NIH/3T3, MCF-7 cancer cell lines, antioxidant and enzyme inhibition studies. Drug Des Dev Ther 13:4185CrossRef
Zurück zum Zitat Ahmad S et al (2021) Evaluation of analgesic, antiamnesic and antidiarrheal potentials of Medicago denticulata extract using animal model. Saudi Journal of Biological Sciences 28(11):6352–6358CrossRefPubMedPubMedCentral Ahmad S et al (2021) Evaluation of analgesic, antiamnesic and antidiarrheal potentials of Medicago denticulata extract using animal model. Saudi Journal of Biological Sciences 28(11):6352–6358CrossRefPubMedPubMedCentral
Zurück zum Zitat Ahmad, A., et al., Comparative cholinesterase, α-glucosidase inhibitory, antioxidant, molecular docking, and kinetic studies on potent succinimide derivatives. Drug Design, Development and Therapy, 2020: p. 2165–2178. Ahmad, A., et al., Comparative cholinesterase, α-glucosidase inhibitory, antioxidant, molecular docking, and kinetic studies on potent succinimide derivatives. Drug Design, Development and Therapy, 2020: p. 2165–2178.
Zurück zum Zitat Alam F et al (2023) In vitro, in vivo and in silico evaluation of analgesic, anti-inflammatory, and anti-pyretic activity of salicylate rich fraction from Gaultheria trichophylla Royle (Ericaceae). J Ethnopharmacol 301:115828CrossRefPubMed Alam F et al (2023) In vitro, in vivo and in silico evaluation of analgesic, anti-inflammatory, and anti-pyretic activity of salicylate rich fraction from Gaultheria trichophylla Royle (Ericaceae). J Ethnopharmacol 301:115828CrossRefPubMed
Zurück zum Zitat Alam, W., et al., Synthesis, in-vitro inhibition of cyclooxygenases and in silico studies of new isoxazole derivatives. Frontiers in chemistry, 2023. 11. Alam, W., et al., Synthesis, in-vitro inhibition of cyclooxygenases and in silico studies of new isoxazole derivatives. Frontiers in chemistry, 2023. 11.
Zurück zum Zitat Ali, G., et al., 2-Hydroxybenzohydrazide as a novel potential candidate against nociception, inflammation, and pyrexia: in vitro, in vivo, and computational approaches. Inflammopharmacology, 2023: p. 1–14. Ali, G., et al., 2-Hydroxybenzohydrazide as a novel potential candidate against nociception, inflammation, and pyrexia: in vitro, in vivo, and computational approaches. Inflammopharmacology, 2023: p. 1–14.
Zurück zum Zitat Alqahtani YS (2021) Bioactive stigmastadienone from Isodon rugosus as potential anticholinesterase, α-glucosidase and COX/LOX inhibitor: In-vitro and molecular docking studies. Steroids 172:108857CrossRefPubMed Alqahtani YS (2021) Bioactive stigmastadienone from Isodon rugosus as potential anticholinesterase, α-glucosidase and COX/LOX inhibitor: In-vitro and molecular docking studies. Steroids 172:108857CrossRefPubMed
Zurück zum Zitat Alqahtani, Y.S., et al., Anti-Inflammatory Potentials of β-Ketoester Derivatives of N-Ary Succinimides: In Vitro, In Vivo, and Molecular Docking Studies. Journal of Chemistry, 2022. 2022: p. 1–11. Alqahtani, Y.S., et al., Anti-Inflammatory Potentials of β-Ketoester Derivatives of N-Ary Succinimides: In Vitro, In Vivo, and Molecular Docking Studies. Journal of Chemistry, 2022. 2022: p. 1–11.
Zurück zum Zitat Alqahtani, Y.S., et al., Research Article Anti-Inflammatory Potentials of β-Ketoester Derivatives of N-Ary Succinimides: In Vitro, In Vivo, and Molecular Docking Studies. 2022. Alqahtani, Y.S., et al., Research Article Anti-Inflammatory Potentials of β-Ketoester Derivatives of N-Ary Succinimides: In Vitro, In Vivo, and Molecular Docking Studies. 2022.
Zurück zum Zitat Sadiq A, Mahnashi MH, Alyami BA, Alqahtani YS, Alqarni AO, Rashid U (2021) Tailoring the substitution pattern of pyrrolidine-2,5-dione for discovery of new structural template for dual COX/LOX inhibition. Bioorg Chem 112:104969CrossRefPubMed Sadiq A, Mahnashi MH, Alyami BA, Alqahtani YS, Alqarni AO, Rashid U (2021) Tailoring the substitution pattern of pyrrolidine-2,5-dione for discovery of new structural template for dual COX/LOX inhibition. Bioorg Chem 112:104969CrossRefPubMed
Zurück zum Zitat Huneif MA, Mahnashi MH, Jan MS, Shah M, Almedhesh SA, Alqahtani SM, Alzahrani MJ, Ayaz M, Ullah F, Rashid U, Sadiq A (2023) New Succinimide-Thiazolidinedione Hybrids as Multitarget Antidiabetic Agents: Design, Synthesis, Bioevaluation, and Molecular Modelling Studies. Molecules 28(3):1207CrossRefPubMedPubMedCentral Huneif MA, Mahnashi MH, Jan MS, Shah M, Almedhesh SA, Alqahtani SM, Alzahrani MJ, Ayaz M, Ullah F, Rashid U, Sadiq A (2023) New Succinimide-Thiazolidinedione Hybrids as Multitarget Antidiabetic Agents: Design, Synthesis, Bioevaluation, and Molecular Modelling Studies. Molecules 28(3):1207CrossRefPubMedPubMedCentral
Zurück zum Zitat Pervaiz A, Jan MS, Hassan Shah SM, Khan A, Zafar R, Ansari B, Shahid M, Hussain F, Ijaz Khan M, Zeb A, Mukarram Shah SM (2022) Comparative in-vitro anti-inflammatory, anticholinesterase and antidiabetic evaluation: Computational and kinetic assessment of succinimides cyano-acetate derivatives. J Biomol Struct Dyn 4:1–14CrossRef Pervaiz A, Jan MS, Hassan Shah SM, Khan A, Zafar R, Ansari B, Shahid M, Hussain F, Ijaz Khan M, Zeb A, Mukarram Shah SM (2022) Comparative in-vitro anti-inflammatory, anticholinesterase and antidiabetic evaluation: Computational and kinetic assessment of succinimides cyano-acetate derivatives. J Biomol Struct Dyn 4:1–14CrossRef
Zurück zum Zitat Anity Singh, D., Audit on assessment of adequacy of Postoperative Analgesia in a Tertiary Care Centre: An Observational study. 2013, Christian Medical College, Vellore. Anity Singh, D., Audit on assessment of adequacy of Postoperative Analgesia in a Tertiary Care Centre: An Observational study. 2013, Christian Medical College, Vellore.
Zurück zum Zitat Chandran D (2021) Veterinary phytomedicine in India: a review. Int J Sci Res Sci Tech 8(3):598–605CrossRef Chandran D (2021) Veterinary phytomedicine in India: a review. Int J Sci Res Sci Tech 8(3):598–605CrossRef
Zurück zum Zitat Chinsamy M, Finnie J, Van Staden J (2014) Anti-inflammatory, antioxidant, anti-cholinesterase activity and mutagenicity of South African medicinal orchids. S Afr J Bot 91:88–98CrossRef Chinsamy M, Finnie J, Van Staden J (2014) Anti-inflammatory, antioxidant, anti-cholinesterase activity and mutagenicity of South African medicinal orchids. S Afr J Bot 91:88–98CrossRef
Zurück zum Zitat Finch SC, Boundy MJ, Harwood DT (2018) The acute toxicity of tetrodotoxin and tetrodotoxin–saxitoxin mixtures to mice by various routes of administration. Toxins 10(11):423CrossRefPubMedPubMedCentral Finch SC, Boundy MJ, Harwood DT (2018) The acute toxicity of tetrodotoxin and tetrodotoxin–saxitoxin mixtures to mice by various routes of administration. Toxins 10(11):423CrossRefPubMedPubMedCentral
Zurück zum Zitat Genovese M et al (2021) Natural α-glucosidase and protein tyrosine phosphatase 1B inhibitors: A source of scaffold molecules for synthesis of new multitarget antidiabetic drugs. Molecules 26(16):4818CrossRefPubMedPubMedCentral Genovese M et al (2021) Natural α-glucosidase and protein tyrosine phosphatase 1B inhibitors: A source of scaffold molecules for synthesis of new multitarget antidiabetic drugs. Molecules 26(16):4818CrossRefPubMedPubMedCentral
Zurück zum Zitat Hussain F et al (2019) Synthesis, in-vitro α-glucosidase inhibition, antioxidant, in-vivo antidiabetic and molecular docking studies of pyrrolidine-2, 5-dione and thiazolidine-2, 4-dione derivatives. Bioorg Chem 91:103128CrossRefPubMed Hussain F et al (2019) Synthesis, in-vitro α-glucosidase inhibition, antioxidant, in-vivo antidiabetic and molecular docking studies of pyrrolidine-2, 5-dione and thiazolidine-2, 4-dione derivatives. Bioorg Chem 91:103128CrossRefPubMed
Zurück zum Zitat Jan MS et al (2020) Design, synthesis, in-vitro, in-vivo and in-silico studies of pyrrolidine-2, 5-dione derivatives as multitarget anti-inflammatory agents. Eur J Med Chem 186:111863CrossRefPubMed Jan MS et al (2020) Design, synthesis, in-vitro, in-vivo and in-silico studies of pyrrolidine-2, 5-dione derivatives as multitarget anti-inflammatory agents. Eur J Med Chem 186:111863CrossRefPubMed
Zurück zum Zitat Javed MA et al (2021) Structural modification, in vitro, in vivo, ex vivo, and in silico exploration of pyrimidine and pyrrolidine cores for targeting enzymes associated with neuroinflammation and cholinergic deficit in Alzheimer’s disease. ACS Chem Neurosci 12(21):4123–4143CrossRefPubMed Javed MA et al (2021) Structural modification, in vitro, in vivo, ex vivo, and in silico exploration of pyrimidine and pyrrolidine cores for targeting enzymes associated with neuroinflammation and cholinergic deficit in Alzheimer’s disease. ACS Chem Neurosci 12(21):4123–4143CrossRefPubMed
Zurück zum Zitat Javed MA et al (2022) Diclofenac derivatives as concomitant inhibitors of cholinesterase, monoamine oxidase, cyclooxygenase-2 and 5-lipoxygenase for the treatment of Alzheimer’s disease: synthesis, pharmacology, toxicity and docking studies. RSC Adv 12(35):22503–22517CrossRefPubMedPubMedCentral Javed MA et al (2022) Diclofenac derivatives as concomitant inhibitors of cholinesterase, monoamine oxidase, cyclooxygenase-2 and 5-lipoxygenase for the treatment of Alzheimer’s disease: synthesis, pharmacology, toxicity and docking studies. RSC Adv 12(35):22503–22517CrossRefPubMedPubMedCentral
Zurück zum Zitat Javed MA et al (2023) Evaluation of pyrimidine/pyrrolidine-sertraline based hybrids as multitarget anti-Alzheimer agents: In-vitro, in-vivo, and computational studies. Biomed Pharmacother 159:114239CrossRefPubMed Javed MA et al (2023) Evaluation of pyrimidine/pyrrolidine-sertraline based hybrids as multitarget anti-Alzheimer agents: In-vitro, in-vivo, and computational studies. Biomed Pharmacother 159:114239CrossRefPubMed
Zurück zum Zitat Khan J et al (2021) Mechanistic evaluation of a novel cyclohexenone derivative’s functionality against nociception and inflammation: an in-vitro, in-vivo and in-silico approach. Eur J Pharmacol 902:174091CrossRefPubMed Khan J et al (2021) Mechanistic evaluation of a novel cyclohexenone derivative’s functionality against nociception and inflammation: an in-vitro, in-vivo and in-silico approach. Eur J Pharmacol 902:174091CrossRefPubMed
Zurück zum Zitat Khan A et al (2022) Phytochemical profiling, anti-inflammatory, anti-oxidant and in-silico approach of cornus macrophylla bioss (Bark). Molecules 27(13):4081CrossRefPubMedPubMedCentral Khan A et al (2022) Phytochemical profiling, anti-inflammatory, anti-oxidant and in-silico approach of cornus macrophylla bioss (Bark). Molecules 27(13):4081CrossRefPubMedPubMedCentral
Zurück zum Zitat Kozarski M et al (2019) Ganoderma lucidum as a cosmeceutical: Antiradical potential and inhibitory effect on hyperpigmentation and skin extracellular matrix degradation enzymes. Archives of Biological Sciences 71(2):253–264CrossRef Kozarski M et al (2019) Ganoderma lucidum as a cosmeceutical: Antiradical potential and inhibitory effect on hyperpigmentation and skin extracellular matrix degradation enzymes. Archives of Biological Sciences 71(2):253–264CrossRef
Zurück zum Zitat Kumar N et al (2011) Anti-oxidative and immuno-hematological status of Tilapia (Oreochromis mossambicus) during acute toxicity test of endosulfan. Pestic Biochem Physiol 99(1):45–52CrossRef Kumar N et al (2011) Anti-oxidative and immuno-hematological status of Tilapia (Oreochromis mossambicus) during acute toxicity test of endosulfan. Pestic Biochem Physiol 99(1):45–52CrossRef
Zurück zum Zitat Mahmood F et al (2022) Anti-inflammatory, analgesic and antioxidant potential of new (2 S, 3 S)-2-(4-isopropylbenzyl)-2-methyl-4-nitro-3-phenylbutanals and their Corresponding carboxylic acids through in vitro, in silico and in vivo studies. Molecules 27(13):4068CrossRefPubMedPubMedCentral Mahmood F et al (2022) Anti-inflammatory, analgesic and antioxidant potential of new (2 S, 3 S)-2-(4-isopropylbenzyl)-2-methyl-4-nitro-3-phenylbutanals and their Corresponding carboxylic acids through in vitro, in silico and in vivo studies. Molecules 27(13):4068CrossRefPubMedPubMedCentral
Zurück zum Zitat Mahnashi MH et al (2022) In-vitro, in-vivo, molecular docking and ADMET studies of 2-substituted 3, 7-dihydroxy-4H-chromen-4-one for oxidative stress, inflammation and Alzheimer’s disease. Metabolites 12(11):1055CrossRefPubMedPubMedCentral Mahnashi MH et al (2022) In-vitro, in-vivo, molecular docking and ADMET studies of 2-substituted 3, 7-dihydroxy-4H-chromen-4-one for oxidative stress, inflammation and Alzheimer’s disease. Metabolites 12(11):1055CrossRefPubMedPubMedCentral
Zurück zum Zitat Jan MS, Alshehri OM, Zeb A, Mukarram SM, Mahnashi MH, Asiri S, Alqahtani O, Sadiq A, Ibrar M, Alshamrani S (2024) Investigation of anti-nociceptive, anti-inflammatory potential and ADMET studies of pure compounds isolated from isodon rugosus wall. ex Benth. Front Pharmacol 15:1328128CrossRefPubMedPubMedCentral Jan MS, Alshehri OM, Zeb A, Mukarram SM, Mahnashi MH, Asiri S, Alqahtani O, Sadiq A, Ibrar M, Alshamrani S (2024) Investigation of anti-nociceptive, anti-inflammatory potential and ADMET studies of pure compounds isolated from isodon rugosus wall. ex Benth. Front Pharmacol 15:1328128CrossRefPubMedPubMedCentral
Zurück zum Zitat Mahnashi, M.H., et al., Phytochemical profiling of bioactive compounds, anti-inflammatory and analgesic potentials of Habenaria digitata Lindl.: Molecular docking based synergistic effect of the identified compounds. Journal of ethnopharmacology, 2021. 273: p. 113976. Mahnashi, M.H., et al., Phytochemical profiling of bioactive compounds, anti-inflammatory and analgesic potentials of Habenaria digitata Lindl.: Molecular docking based synergistic effect of the identified compounds. Journal of ethnopharmacology, 2021. 273: p. 113976.
Zurück zum Zitat Mahnashi, M.H., et al., Antioxidant molecules isolated from edible prostrate knotweed: rational derivatization to produce more potent molecules. Oxidative medicine and cellular longevity, 2022. 2022. Mahnashi, M.H., et al., Antioxidant molecules isolated from edible prostrate knotweed: rational derivatization to produce more potent molecules. Oxidative medicine and cellular longevity, 2022. 2022.
Zurück zum Zitat Mansouri MT et al (2015) A study of the mechanisms underlying the anti-inflammatory effect of ellagic acid in carrageenan-induced paw edema in rats. Indian J Pharmacol 47(3):292CrossRefPubMedPubMedCentral Mansouri MT et al (2015) A study of the mechanisms underlying the anti-inflammatory effect of ellagic acid in carrageenan-induced paw edema in rats. Indian J Pharmacol 47(3):292CrossRefPubMedPubMedCentral
Zurück zum Zitat Mohammadifard F, Alimohammadi S (2018) Chemical composition and role of opioidergic system in antinociceptive effect of Ziziphora clinopodioides essential oil. Basic and Clinical Neuroscience 9(5):357CrossRefPubMedPubMedCentral Mohammadifard F, Alimohammadi S (2018) Chemical composition and role of opioidergic system in antinociceptive effect of Ziziphora clinopodioides essential oil. Basic and Clinical Neuroscience 9(5):357CrossRefPubMedPubMedCentral
Zurück zum Zitat Muhammad N, Saeed M, Khan H (2012a) Antipyretic, analgesic and anti-inflammatory activity of Viola betonicifolia whole plant. BMC Complement Altern Med 12(1):1–8CrossRef Muhammad N, Saeed M, Khan H (2012a) Antipyretic, analgesic and anti-inflammatory activity of Viola betonicifolia whole plant. BMC Complement Altern Med 12(1):1–8CrossRef
Zurück zum Zitat Muhammad N, Saeed M, Khan H (2012b) Antipyretic, analgesic and anti-inflammatory activity of Viola betonicifolia whole plant. BMC Complement Altern Med 12:1–8CrossRef Muhammad N, Saeed M, Khan H (2012b) Antipyretic, analgesic and anti-inflammatory activity of Viola betonicifolia whole plant. BMC Complement Altern Med 12:1–8CrossRef
Zurück zum Zitat Muhammad, N., et al., In-vitro and in-vivo assessment of the anti-diabetic, analgesic, and anti-inflammatory potenstials of metal-based carboxylates derivative. Heliyon, 2023. 9(8). Muhammad, N., et al., In-vitro and in-vivo assessment of the anti-diabetic, analgesic, and anti-inflammatory potenstials of metal-based carboxylates derivative. Heliyon, 2023. 9(8).
Zurück zum Zitat Munir A et al (2020) Synthesis, in-vitro, in-vivo anti-inflammatory activities and molecular docking studies of acyl and salicylic acid hydrazide derivatives. Bioorg Chem 104:104168CrossRefPubMed Munir A et al (2020) Synthesis, in-vitro, in-vivo anti-inflammatory activities and molecular docking studies of acyl and salicylic acid hydrazide derivatives. Bioorg Chem 104:104168CrossRefPubMed
Zurück zum Zitat Owoyele BV et al (2013) Analgesic, anti-inflammatory and antipyretic activities from flavonoid fractions of Chromolaena odorata. Journal of Medicinal Plants Research 2(9):219–225 Owoyele BV et al (2013) Analgesic, anti-inflammatory and antipyretic activities from flavonoid fractions of Chromolaena odorata. Journal of Medicinal Plants Research 2(9):219–225
Zurück zum Zitat Pant B (2013) Medicinal orchids and their uses: Tissue culture a potential alternative for conservation. African Journal of Plant Science 7(10):448–467CrossRef Pant B (2013) Medicinal orchids and their uses: Tissue culture a potential alternative for conservation. African Journal of Plant Science 7(10):448–467CrossRef
Zurück zum Zitat Portoghese PS (1965) A new concept on the mode of interaction of narcotic analgesics with receptors. J Med Chem 8(5):609–616CrossRefPubMed Portoghese PS (1965) A new concept on the mode of interaction of narcotic analgesics with receptors. J Med Chem 8(5):609–616CrossRefPubMed
Zurück zum Zitat Scarborough, B.M. and C.B. Smith, Optimal pain management for patients with cancer in the modern era. CA: a cancer journal for clinicians, 2018. 68(3): p. 182–196. Scarborough, B.M. and C.B. Smith, Optimal pain management for patients with cancer in the modern era. CA: a cancer journal for clinicians, 2018. 68(3): p. 182–196.
Zurück zum Zitat Shah M et al (2023) SAR and lead optimization of (Z)-5-(4-hydroxy-3-methoxybenzylidene)-3-(2-morpholinoacetyl) thiazolidine-2, 4-dione as a potential multi-target antidiabetic agent. Eur J Med Chem 258:115591CrossRefPubMed Shah M et al (2023) SAR and lead optimization of (Z)-5-(4-hydroxy-3-methoxybenzylidene)-3-(2-morpholinoacetyl) thiazolidine-2, 4-dione as a potential multi-target antidiabetic agent. Eur J Med Chem 258:115591CrossRefPubMed
Zurück zum Zitat Sinclair, R.R., et al., Occupational health science in the time of COVID-19: Now more than ever. 2020, Springer. p. 1–22. Sinclair, R.R., et al., Occupational health science in the time of COVID-19: Now more than ever. 2020, Springer. p. 1–22.
Zurück zum Zitat Thiruchenthooran V, Sánchez-López E, Gliszczyńska A (2023) Perspectives of the application of non-steroidal anti-inflammatory drugs in cancer therapy: Attempts to overcome their unfavorable side effects. Cancers 15(2):475CrossRefPubMedPubMedCentral Thiruchenthooran V, Sánchez-López E, Gliszczyńska A (2023) Perspectives of the application of non-steroidal anti-inflammatory drugs in cancer therapy: Attempts to overcome their unfavorable side effects. Cancers 15(2):475CrossRefPubMedPubMedCentral
Zurück zum Zitat Yu W-L et al (2023) Changes of local microenvironment and systemic immunity after acupuncture stimulation during inflammation: A literature review of animal studies. Front Neurol 13:1086195CrossRefPubMedPubMedCentral Yu W-L et al (2023) Changes of local microenvironment and systemic immunity after acupuncture stimulation during inflammation: A literature review of animal studies. Front Neurol 13:1086195CrossRefPubMedPubMedCentral
Zurück zum Zitat Zafar R et al (2021) Zinc metal carboxylates as potential anti-Alzheimer’s candidate: in vitro anticholinesterase, antioxidant and molecular docking studies. J Biomol Struct Dyn 39(3):1044–1054CrossRefPubMed Zafar R et al (2021) Zinc metal carboxylates as potential anti-Alzheimer’s candidate: in vitro anticholinesterase, antioxidant and molecular docking studies. J Biomol Struct Dyn 39(3):1044–1054CrossRefPubMed
Metadaten
Titel
Isolation, invitro, invivo anti-inflammatory, analgesic and antioxidant potential of Habenaria plantegania Lindl
verfasst von
Osama M. Alshehri
Madeeha Shabnam
Saeed Ahmed Asiri
Mater H. Mahnashi
Abdul Sadiq
Muhammad Saeed Jan
Publikationsdatum
09.02.2024
Verlag
Springer International Publishing
Erschienen in
Inflammopharmacology / Ausgabe 2/2024
Print ISSN: 0925-4692
Elektronische ISSN: 1568-5608
DOI
https://doi.org/10.1007/s10787-023-01425-4

Weitere Artikel der Ausgabe 2/2024

Inflammopharmacology 2/2024 Zur Ausgabe