Clinical and Experimental Nephrology OnlineFirst articles

Open Access 22.04.2024 | Invited review article

Targeting ferroptosis for treating kidney disease

Ferroptosis is a type of regulated cell death hallmarked by iron-mediated excessive lipid oxidation. Over the past decade since the coining of the term ferroptosis, advances in research have led to the identification of intracellular processes …

verfasst von:: Eikan Mishima

PDF-Version jetzt herunterladen Zum Volltext

Open Access 20.04.2024 | Rapid communication

Effects of empagliflozin in patients with chronic kidney disease from Japan: exploratory analyses from EMPA–KIDNEY

Four large-scale placebo-controlled outcome trials have studied the effects of sodium–glucose co-transporter-2 (SGLT2) inhibitors in different populations of patients with chronic kidney disease (CKD). Meta-analysis has demonstrated clear net …

verfasst von:: Masaomi Nangaku, William G. Herrington, Shinya Goto, Shoichi Maruyama, Naoki Kashihara, Kohjiro Ueki, Jun Wada, Hirotaka Watada, Eitaro Nakashima, Ryonfa Lee, Dan Massey, Kaitlin J. Mayne, Aiko Tomita, Richard Haynes, Sibylle J. Hauske, Takashi Kadowaki

PDF-Version jetzt herunterladen Zum Volltext

Open Access 20.04.2024 | Original article

Effects of 1-week inpatient multidisciplinary care for chronic kidney disease prior to outpatient collaborative care

Chronic kidney disease (CKD) is a disease for which continuous multidisciplinary care, including nephrologists, nurses, pharmacists, and dietitians, is important. Multidisciplinary care for CKD has been reported to prevent deterioration of renal …

verfasst von:: Natsuko Okuno, Hiroshi Kado, Hiroyoshi Segawa, Tsuguru Hatta

PDF-Version jetzt herunterladen Zum Volltext

Open Access 20.04.2024 | Original article

Circulating galectin-3 level association with cardiovascular risk factors during peritoneal dialysis

Chronic kidney disease (CKD) represents a substantial clinical and public health challenge due to its escalating incidence and prevalence rates. It stands as a prominent contributor to both morbidity and mortality associated with end-stage renal …

verfasst von:: Xuerui Yang, Jun Yang, Youjia Zeng, Ling Peng, Xingzheng Liu, Jinying Mo, Taifen Wang, Yutong Yao, Yihou Zheng, Gaofeng Song

PDF-Version jetzt herunterladen Zum Volltext

Open Access 17.04.2024 | Invited review article

Targeting inflammation in perivascular cells and neuroimmune interactions for treating kidney disease

Inflammation plays a crucial role in the pathophysiology of various kidney diseases. Kidney perivascular cells (pericytes/fibroblasts) are responsible for producing proinflammatory molecules, promoting immune cell infiltration, and enhancing …

verfasst von:: Shinji Tanaka

PDF-Version jetzt herunterladen Zum Volltext

14.04.2024 | Original article

Renal outcome of living kidney donors aged more than 70 years

Although kidney transplantation is described as an effective treatment modality for patients with end-stage kidney disease (ESKD), the shortage of organ donations is critical problem in Japan [ 1 ]. According to a report from the International …

verfasst von:: Rikako Oki, Kohei Unagami, Taro Banno, Toshihito Hirai, Kazuya Omoto, Tomokazu Shimizu, Sekiko Taneda, Junichi Hoshino, Toshio Takagi, Hideki Ishida

Open Access 13.04.2024 | Original article

Letermovir safety and efficacy for cytomegalovirus prophylaxis in adult Japanese kidney transplant recipients: a multicenter, open-label, noncomparative Phase 3 study

In solid organ transplant (SOT) recipients receiving immunosuppressive drugs, cytomegalovirus (CMV) disease is associated with substantial morbidity and mortality [ 1 , 2 ]. Direct (CMV syndrome, end-organ disease) and indirect (e.g., allograft …

verfasst von:: Hideki Ishida, Norihiko Goto, Ryoichi Imamura, Hajime Sasaki, Kohei Unagami, Kenta Futamura, Yoshihiko Murata, Nobuyuki Oshima, Toshiko Eto, Barbara Haber

PDF-Version jetzt herunterladen Zum Volltext

13.04.2024 | Original article

Efficacy and safety of telitacicept in patients with lupus nephritis: a single-center, real-world retrospective study

When systemic lupus erythematosus (SLE) disease involves the kidneys, patients may present with symptoms such as hematuria, proteinuria, edema, hypertension, and anemia, indicating SLE nephritis [ 1 ]. The kidneys are the most commonly affected …

verfasst von:: Xiaolu Huang, Fuan Lin, Hongpu Chen

13.04.2024 | Original article

Comparative effects of sodium–glucose cotransporter 2 inhibitors versus dipeptidyl peptidase-4 inhibitors on kidney function decline in Japanese individuals with type 2 diabetes

Sodium-glucose cotransporter 2 inhibitors (SGLT2is) have become a silver lining in the dark cloud of diabetic nephropathy [ 1 – 3 ], a global public health concern [ 4 – 7 ]. The Canagliflozin and Renal Events in Diabetes with Established …

verfasst von:: Naoshi Yoshida, Ko Hanai, Tetsuya Babazono

09.04.2024 | Original article

Calcium-based phosphate binders and bone mineral density in patients undergoing hemodialysis: a retrospective cohort study

Patients on hemodialysis face a high risk of fracture, approximately five times that of the general population [ 1 ]. Furthermore, the risk of death in these patients is known to increase after the occurrence of fracture [ 2 , 3 ]. This underscores …

verfasst von:: Kazuhiko Kato, Akio Nakashima, Masamitsu Morishita, Ichiro Ohkido, Takashi Yokoo

08.04.2024 | Original article

Association between lactate dehydrogenase to albumin ratio and acute kidney injury in patients with sepsis: a retrospective cohort study

Acute kidney injury (AKI) is a frequent clinical complication caused by a variety of events that affect the perfusion or parenchyma of the kidney, including sepsis, nephrotoxic drugs, and renal ischemia [ 1 ]. Approximately 55–73% of patients …

verfasst von:: Weigan Xu, Jianyang Huo, Qiaohua Hu, Jingtao Xu, Guojun Chen, Jierong Mo, Tianen Zhou, Jun Jiang

08.04.2024 | Review article

Ability of NAD and Sirt1 to epigenetically suppress albuminuria

The time for diabetic nephropathy (DN) to progress from mild to severe is long. Thus, methods to continuously repress DN are required to exert long-lasting effects mediated through epigenetic regulation. In this study, we demonstrated the ability …

verfasst von:: Kazuhiro Hasegawa, Masanori Tamaki, Eriko Shibata, Taizo Inagaki, Masanori Minato, Sumiyo Yamaguchi, Ikuko Shimizu, Shinji Miyakami, Miho Tada, Shu Wakino

06.04.2024 | Original article

Zinc deficiency induces hypertension by paradoxically amplifying salt sensitivity under high salt intake in mice

Chronic kidney disease (CKD) is a global health problem that deteriorates renal function, leading to end-stage renal disease and cardiovascular diseases [ 1 , 2 ]. The importance of preventing the progression of CKD is widely recognized.

verfasst von:: Marie Yamamoto, Tomoaki Takata, Hinako Hanada, Sosuke Taniguchi, Shintaro Hamada, Yukari Mae, Takuji Iyama, Tsutomu Kanda, Hajime Isomoto

06.04.2024 | Original article

Cigarette smoking and progression of kidney dysfunction: a longitudinal cohort study

Chronic kidney disease (CKD) is one of the important common diseases, because CKD causes not only end stage kidney disease requiring dialysis therapy, also cardiovascular diseases [ 1 – 5 ]. CKD affects around 10% of the general population in the …

verfasst von:: Ayako Matsumoto, Yasuyuki Nagasawa, Ryouhei Yamamoto, Maki Shinzawa, Hiromitsu Yamazaki, Kensaku Shojima, Ken Shinmura, Yoshitaka Isaka, Kunitoshi Iseki, Kunihiro Yamagata, Ichiei Narita, Tsuneo Konta, Masahide Kondo, Kazuhiko Tsuruya, Masato Kasahara, Yugo Shibagaki, Shouichi Fujimoto, Koichi Asahi, Tsuyoshi Watanabe, Toshiki Moriyama

Open Access 27.03.2024 | Original article

Machine learning in risk prediction of continuous renal replacement therapy after coronary artery bypass grafting surgery in patients

Coronary artery bypass grafting (CABG) as an effective way of myocardial revascularization is a remarkably successful operation and is commonly employed for patients with high-grade or complex coronary artery stenosis. However, the high incidence …

verfasst von:: Qian Zhang, Peng Zheng, Zhou Hong, Luo Li, Nannan Liu, Zhiping Bian, Xiangjian Chen, Hengfang Wu, Sheng Zhao

PDF-Version jetzt herunterladen Zum Volltext

Open Access 26.03.2024 | Original article

Multicenter randomized controlled trial of intensive uric acid lowering therapy for CKD patients with hyperuricemia: TARGET-UA

In many countries, prevention of chronic kidney disease (CKD) is an important issue. Hyperuricemia is known to reduce renal function through endothelial dysfunction [ 1 ], renal tubular injury [ 2 ], and glomerular sclerosis [ 3 ]. Clinical studies …

verfasst von:: Tetsuya Yamamoto, Masato Kasahara, Kenji Ueshima, Shiro Uemura, Naoki Kashihara, Kenjiro Kimura, Tsuneo Konta, Tetsuo Shoji, Akira Mima, Masashi Mukoyama, Yoshihiko Saito

PDF-Version jetzt herunterladen Zum Volltext

20.03.2024 | Correction

Correction to: AHA Life’s Essential 8 and new‑onset CKD: a prospective cohort study from the UK Biobank

verfasst von:: Yong-Xiang Ruan, Mao-Xiong Wu, Jing-Wei Gao, Da-Chuan Guo, Yang-Wei Cai, Ze-Gui Huang, Wan-Bing He, Yang-Xin Chen, Jing-Feng Wang, Hai-Feng Zhang

20.03.2024 | Original article

Kidney damage relates to agonal bacteremia: a single-center retrospective study

Agonal bacteremia is diagnosed based on a positive blood culture result obtained after death (agonal state). Previously, biases such as agonal spread, postmortem translocation, and contamination of the positive results were of concern; …

verfasst von:: Yumiko Mikami, Meiko Ogawa, Yuuki Hayasaka, Asuka Yamakami, Kanako Hattori, Chizumi Fukazawa, Takafumi Ito, Naoki Kanomata, Hiroyuki Terawaki

20.03.2024 | Original article

Association of serum magnesium levels with renal prognosis in patients with chronic kidney disease

Magnesium is a vital mineral involved in bone formation, enzyme activation, cell signaling, energy production, and metabolism. Most magnesium is found in bones and cells, with a small amount found extracellularly [ 1 , 2 ]. Maintaining proper …

verfasst von:: Seiji Kishi, Takaya Nakashima, Tadahiro Goto, Hajime Nagasu, Craig R. Brooks, Hirokazu Okada, Kouichi Tamura, Toshiaki Nakano, Ichiei Narita, Shoichi Maruyama, Yuichiro Yano, Takashi Yokoo, Takashi Wada, Jun Wada, Masaomi Nangaku, Naoki Kashihara

13.03.2024 | Original article

Genotype–phenotype correlations in children with Gitelman syndrome

Gitelman syndrome (GS) is a rare hereditary salt-losing tubulopathy characterized by chronic hypokalemia due to the inappropriate kidney potassium wasting, hypochloremic metabolic alkalosis, hypomagnesemia, hypocalciuria, and high renin and …

verfasst von:: Myung Hyun Cho, Peong Gang Park, Ji Hyun Kim, Kyung Mi Jang, Jiwon M. Lee, Eun Mi Yang, Se Jin Park, Jin-Soon Suh, Heeyeon Cho, Jung Won Lee, Joo Hoon Lee, Ja Wook Koo, Mee Kyung Namgoong, Kee Hyuck Kim, Yo Han Ahn, Hee Gyung Kang, Hae Il Cheong

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin