Clinical and Experimental Nephrology OnlineFirst articles

12.01.2018 | Original article

Glucosuria and all-cause mortality among general screening participants

In Japan, diabetes mellitus (DM) has been a leading cause of end-stage renal disease (ESRD) since 1998 [ 1 ]. Obesity and metabolic syndrome are considered pre-disease states as they are often associated with the conventional risk factors of …

verfasst von:: Kunitoshi Iseki, Tsuneo Konta, Koichi Asahi, Kunihiro Yamagata, Shouichi Fujimoto, Kazuhiko Tsuruya, Ichiei Narita, Masato Kasahara, Yugo Shibagaki, Toshiki Moriyama, Masahide Kondo, Chiho Iseki, Tsuyoshi Watanabe, For the “Design of the Comprehensive Health Care System for Chronic Kidney Disease (CKD) Based on the Individual Risk Assessment by Specific Health Check”

04.01.2018 | Letter to the editor

Reduction of 50% of renal mass in children: consequences of hyperfiltration up to the fifth decade of life

verfasst von:: Denis A. Cozzi, Silvia Ceccanti, Francesco Cozzi

Open Access 04.01.2018 | Original article

Risk of cardiovascular mortality predicted by the serum calcium level and calcification score at the initiation of dialysis

Cardiovascular disease (CVD) is the leading cause of mortality among patients on hemodialysis (HD) and, therefore, assessing CVD risk factors in these patients is clinically meaningful [ 1 ]. Several factors, including high-sensitivity C-reactive …

verfasst von:: Hiroyuki Sato, Tasuku Nagasawa, Ayako Saito, Mariko Miyazaki

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Open Access 29.12.2017 | Original article

Plasma lyso-Gb3: a biomarker for monitoring fabry patients during enzyme replacement therapy

Fabry disease (OMIM 301500) is an X-linked genetic disorder characterized by deficient activity of α-galactosidase A (GLA, EC 3.2.1.22). The enzymatic defect leads to systemic accumulation of glycolipids, predominantly globotriaosylceramide (Gb3) …

verfasst von:: Hitoshi Sakuraba, Tadayasu Togawa, Takahiro Tsukimura, Hiroshi Kato

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27.12.2017 | Letter to the editor

Controversies of the classification of TMA and the terminology of aHUS

verfasst von:: Hideki Kato, Masaomi Nangaku, Hirokazu Okada, Shoji Kagami

26.12.2017 | Original Article

High-normal albuminuria and incident chronic kidney disease in a male nondiabetic population

Chronic kidney disease (CKD) affects more than 10% of the population globally and is a world health concern [ 1 ]. The financial impact of CKD is also great, with particularly high costs depending on renal replacement therapy and cardiovascular …

verfasst von:: Aki Ashitani, Toshinori Ueno, Ayumu Nakashima, Shigehiro Doi, Kiminori Yamane, Takao Masaki

23.12.2017 | Images in Nephrology

Emphysematous cystitis complicated by unilateral hydronephrosis

verfasst von:: Yoichi Iwafuchi, Yuko Oyama, Ichiei Narita

Open Access 23.12.2017 | Original article

The renoprotective effect and safety of a DPP-4 inhibitor, sitagliptin, at a small dose in type 2 diabetic patients with a renal dysfunction when changed from other DPP-4 inhibitors: REAL trial

In Japan, an investigation conducted by the Japanese Society for Dialysis Therapy showed that the number of patients on dialysis was 324,986 at the end of 2015, which increased by 4,538 from the previous year [ 1 ]. The number indicates that 1 out …

verfasst von:: Koichi Kanozawa, Yuichi Noguchi, Souichi Sugahara, Satoko Nakamura, Hirohisa Yamamoto, Keiko Kaneko, Rika Kono, Saeko Sato, Tomonari Ogawa, Hajime Hasegawa, Shigehiro Katayama

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Open Access 21.12.2017 | Invited review article

Vitamin D and renal outcome: the fourth outcome of CKD-MBD? Oshima Award Address 2015

Bone fracture, cardiovascular events, and mortality are three outcomes of chronic kidney disease-mineral and bone disorder (CKD-MBD), and the umbrella concept originally described for dialysis patients. The reported association of serum phosphorus …

verfasst von:: Takayuki Hamano

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12.12.2017 | Original article

The clinical relevance of plasma CD147/basigin in biopsy-proven kidney diseases

Regardless of the primary process, persistent kidney injury provokes irreversible pathological changes such as glomerular obsolescence and interstitial fibrosis, eventually leading to the development of chronic kidney disease (CKD) with an …

verfasst von:: Yoshiko Mori, Tomohiro Masuda, Tomoki Kosugi, Tomoki Yoshioka, Mayuko Hori, Hiroshi Nagaya, Kayaho Maeda, Yuka Sato, Hiroshi Kojima, Noritoshi Kato, Takuji Ishimoto, Takayuki Katsuno, Yukio Yuzawa, Kenji Kadomatsu, Shoichi Maruyama

11.12.2017 | Original article

Arterial wall hypertrophy is ameliorated by α2-adrenergic receptor antagonist or aliskiren in kidneys of angiotensinogen-knockout mice

Angiotensinogen-knockout ( Atg −/− ) mice lack angiotensinogen, the upstream substrate of the renin-angiotensin system (RAS), and express phenotypes associated with low RAS activity such as hypotension and impaired urinary concentrating capacity [ …

verfasst von:: Haruka Nakamori, Shin-ichiro Yoshida, Hiroaki Ishiguro, Shota Suzuki, Hiroaki Yasuzaki, Tatsuo Hashimoto, Tomoaki Ishigami, Nobuhito Hirawa, Yoshiyuki Toya, Satoshi Umemura, Kouichi Tamura

Open Access 07.12.2017 | Original article

Ionized and total serum magnesium in hemodialysis: predictors and variability. A longitudinal cross-sectional study

Ionized Magnesium (ion-Mg) represents the active and the most abundant biological fraction of the serum magnesium [ 1 , 2 ]. Nevertheless, despite having several limitations, the assessment of the total serum Mg (tot-Mg) concentration is the only …

verfasst von:: Rosaria Del Giorno, Hilary Riva, Gaetano Donato, Luca Gabutti

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Open Access 06.12.2017 | Original article

Clinical features and pathogenesis of membranoproliferative glomerulonephritis: a nationwide analysis of the Japan renal biopsy registry from 2007 to 2015

Membranoproliferative glomerulonephritis (MPGN), also termed as mesangiocapillary glomerulonephritis, is a morphological pattern of injury characterized by mesangial hypercellularity, endocapillary proliferation, capillary wall remodeling, double …

verfasst von:: Naoki Nakagawa, Naoyuki Hasebe, Motoshi Hattori, Michio Nagata, Hitoshi Yokoyama, Hiroshi Sato, Hitoshi Sugiyama, Akira Shimizu, Yoshitaka Isaka, Shoichi Maruyama, Ichiei Narita

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04.12.2017 | Original article

The functionality of African-specific variants in the TGFB1 regulatory region and their potential role in HIVAN

Transforming growth factor beta-1 (TGF-β1) plays an important role in immune signalling. In the kidney TGF-β1 is expressed in proximal renal tubular epithelial cells and the glomerular basement membrane [ 1 , 2 ]. The effect of TGF-β1 is context …

verfasst von:: M. Nel, J.-M. Buys, F. C. J. Botha, N. Wearne, S. Prince, J. M. Heckmann

02.12.2017 | Original article

Prognostic value of intraoperative measurements of renal tissue oxygenation and microcirculation on renal function in partial nephrectomy

The era of radical nephrectomy as the main treatment for renal cell carcinoma (RCC) belongs to the past. In the past 20 years, organ preservation by nephron-sparing surgery has become increasingly important. And partial nephrectomy has become …

verfasst von:: Matthias Maruschke, Katja Hagel, Oliver Hakenberg, Thomas Scheeren

02.12.2017 | Letter to the editor

Distinct renal outcomes for transcatheter aortic valve replacement and surgical repair

verfasst von:: Abhilash Koratala, Shahab Bozorgmehri, Amir Kazory

02.12.2017 | Original Article

Comparison of long-term follow-up outcomes between multiple-drugs combination therapy and tonsillectomy pulse therapy for pediatric IgA nephropathy

Primary immunoglobulin A nephropathy (IgAN) is characterized clinically by microhematuria and proteinuria, and histologically by the deposition of immunoglobulin A. IgAN is the most common form of chronic glomerulonephritis worldwide, and …

verfasst von:: Yukihiko Kawasaki, Ryo Maeda, Syuto Kanno, Yuichi Suzuki, Shinichiro Ohara, Kazuhide Suyama, Mitsuaki Hosoya

01.12.2017 | Original Article

Inverse correlation between left ventricular end-diastolic pressure and contrast-induced nephropathy in patients undergoing percutaneous coronary intervention

Contrast-induced nephropathy (CIN), defined as either a 25% relative increase or an absolute increase of 0.5 mg/dL (44.2 µmol/L) in the serum creatinine (Scr) level at 48–72 h after administration of iodinated contrast media (CM) [ 1 ], is a common …

verfasst von:: Guoqiang Gu, Hanghang Xing, Yaqing Zhou, Wei Cui

28.11.2017 | Original article

Long-term outcome of congenital nephrotic syndrome after kidney transplantation in Japan

Congenital nephrotic syndrome, particularly of the Finnish type (CNF), is a severe hereditary disease that is clinically characterized by a large placenta, albuminuria, hypoalbuminemia, and severe edema [ 1 , 2 ]. Although the incidence of CNF is …

verfasst von:: Yuko Hamasaki, Masaki Muramatsu, Riku Hamada, Kenji Ishikura, Hiroshi Hataya, Hiroyuki Satou, Masataka Honda, Koichi Nakanishi, Seiichiro Shishido

28.11.2017 | Original article

Patient knowledge and adherence to maintenance hemodialysis: an International comparison study

Hemodialysis (HD) is a life-saving procedure for patients with end-stage kidney disease (ESKD). However, some patients skip dialysis sessions, which puts them at an increased risk of hospitalization and death [ 1 – 3 ]. Improved adherence to …

verfasst von:: Kana N. Miyata, Jenny I. Shen, Yasuhide Nishio, Manabu Haneda, Kobena A. Dadzie, Nijal R. Sheth, Renjiro Kuriyama, Chika Matsuzawa, Ken Tachibana, Nikolas B. Harbord, James F. Winchester

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

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