Damage of the endothelial glycocalyx (eGC) plays a central role in the development of vascular hyperpermeability and organ damage during systemic inflammation. However, the specific signalling pathways for eGC damage remain poorly defined. Aim of …
verfasst von:
Carolin Christina Drost, Alexandros Rovas, Irina Osiaevi, Klaus Schughart, Alexander Lukasz, Wolfgang A. Linke, Hermann Pavenstädt, Philipp Kümpers
Sustained angiogenesis stands as a hallmark of cancer. The intricate vascular tumor microenvironment fuels cancer progression and metastasis, fosters therapy resistance, and facilitates immune evasion. Therapeutic strategies targeting tumor …
In European countries, nearly 10% of all hospital admissions are related to respiratory diseases, mainly chronic life-threatening diseases such as COPD, pulmonary hypertension, IPF or lung cancer. The contribution of blood vessels and angiogenesis …
verfasst von:
Maximilian Ackermann, Christopher Werlein, Edith Plucinski, Sophie Leypold, Mark P. Kühnel, Stijn E. Verleden, Hassan A. Khalil, Florian Länger, Tobias Welte, Steven J. Mentzer, Danny D. Jonigk
Diabetic retinopathy has a high probability of causing visual impairment or blindness throughout the disease progression and is characterized by the growth of new blood vessels in the retina at an advanced, proliferative stage. Microglia are a …
Vascular mimicry has been thoroughly investigated in tumor angiogenesis. In this study, we demonstrate for the first time that a process closely resembling tumor vascular mimicry is present during physiological blood vessel formation in tissue …
Age-related macular degeneration (AMD) is a common retinal neurodegenerative disease among the elderly. Neovascular AMD (nAMD), a leading cause of AMD-related blindness, involves choroidal neovascularization (CNV), which can be suppressed by …
verfasst von:
Gideon Obasanmi, Manjosh Uppal, Jing Z. Cui, Jeanne Xi, Myeong Jin Ju, Jun Song, Eleanor To, Siqi Li, Wania Khan, Darian Cheng, John Zhu, Lyden Irani, Isa Samad, Julie Zhu, Hyung-Suk Yoo, Alexandre Aubert, Jonathan Stoddard, Martha Neuringer, David J. Granville, Joanne A. Matsubara
Pathological retinal angiogenesis profoundly impacts visual function in vascular eye diseases, such as retinopathy of prematurity (ROP) in preterm infants and age-related macular degeneration in the elderly. While the involvement of photoreceptors …
verfasst von:
Xudong Wang, Tianxi Wang, Satoshi Kaneko, Emil Kriukov, Enton Lam, Manon Szczepan, Jasmine Chen, Austin Gregg, Xingyan Wang, Angeles Fernandez-Gonzalez, S. Alex Mitsialis, Stella Kourembanas, Petr Baranov, Ye Sun
