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Digestive Diseases and Sciences OnlineFirst articles

30.09.2022 | Original Article

Side Effects of COVID-19 Vaccines in Patients with Inflammatory Bowel Disease in Japan

A novel coronavirus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged at the end of 2019 in the City of Wuhan, China, causing an outbreak of an unusual viral pneumonia known as coronavirus disease 2019 (COVID-19) [ 1 , 2 …

verfasst von:
Haruka Miyazaki, Daisuke Watanabe, Yuki Ito, Norihiro Okamoto, Eri Tokunaga, Yuna Ku, Makoto Ooi, Namiko Hoshi, Yuzo Kodama

Open Access 30.09.2022 | Original Article

Primary Care Providers and Nonalcoholic Fatty Liver Disease: A Needs Assessment Survey

The estimated US prevalence of nonalcoholic fatty liver disease (NAFLD) is 25% and rising, resulting in exponential increases in cirrhosis, hepatocellular carcinoma, and liver-related deaths [ 1 , 2 ]. NAFLD encompasses a range of severity from …

verfasst von:
Kendall B. Islam, Danielle Brandman, Janet N. Chu, Max L. Goldman, Rena K. Fox

30.09.2022 | Original Article

Efficacy and Safety of Bezafibrate Alone or in Combination with Ursodeoxycholic Acid in Primary Biliary Cholangitis: Systematic Review and Meta-Analysis

Primary biliary cholangitis (PBC), a chronic autoimmune cholestatic liver disease characterized by the destruction of small intrahepatic bile ducts, has a slow, progressive course that leads to periportal inflammation, fibrosis, cirrhosis, and …

verfasst von:
Nidah Shabbir Khakoo, Shahnaz Sultan, John M. Reynolds, Cynthia Levy

29.09.2022 | Original Article

Age- and Gender-Based Differences in Anorectal Function, Gastrointestinal Symptoms, and Constipation-Specific Quality of Life in Patients with Chronic Constipation

Chronic constipation (CC) is a common disorder with an estimated global prevalence of ~ 16% [ 1 ]. The disorder is commonly reported in older individuals and females [ 2 ]. Although only a minority of constipated individuals seek health care, CC is …

verfasst von:
Borko Nojkov, Jason R. Baker, William D. Chey, Richard Saad, Lydia Watts, Moira Armstrong, Kristen Collins, Gabrielle Ezell, Cari Phillips, Stacy Menees

29.09.2022 | Original Article

Prepandemic Prevalence Estimates of Fatty Liver Disease and Fibrosis Defined by Liver Elastography in the United States

Fatty liver disease is responsible for considerable morbidity, mortality, and economic cost and is a growing public health burden [ 1 ]. Chronic liver disease and cirrhosis lead to increased morbidity and ranked as the 11th leading cause of death …

verfasst von:
Aynur Unalp-Arida, Constance E. Ruhl

Open Access 28.09.2022 | COVID-19 | Original Article

COVID-19 Pandemic Had Minimal Impact on Colonoscopy Completion After Colorectal Cancer Red Flag Sign or Symptoms in US Veterans

In March 2020, the Coronavirus-2019 (COVID-19) pandemic dramatically impacted how patients interacted with healthcare providers and how they handled urgent and emergent medical conditions [ 1 ]. The Veterans Health Administration (VHA) postponed …

verfasst von:
Joshua Demb, Lin Liu, Ranier Bustamante, Jason A. Dominitz, Ashley Earles, Shailja C. Shah, Andrew J. Gawron, Maria Elena Martinez, Samir Gupta

28.09.2022 | Original Article

Electronic Health Record Work Demands for Gastroenterology and Hepatology Providers: A Prospective Use Analysis and Survey Study

Over the past decade, there has been a rapid adoption of Electronic Health Record (EHR) systems by US hospitals [ 1 ]. EHRs have the potential to improve patient care but, with this adoption, there has been a contemporaneous increase in healthcare …

verfasst von:
Mark Benson, Deepak Gopal, Patrick Pfau

27.09.2022 | Original Article

Similar Time Trends of Hodgkin Lymphoma, Multiple Sclerosis, and Inflammatory Bowel Disease

The etiology of Crohn’s disease (CD) and ulcerative colitis (UC) is still unknown. Several previous studies have shown that the time trends of CD and UC are shaped by underlying birth-cohort patterns [ 1 – 3 ]. Mortality from UC rose in subjects …

verfasst von:
Amnon Sonnenberg

25.09.2022 | Original Article

Antibody Response and Safety of ChAdOx1-nCOV (Covishield) in Patients with Cirrhosis: A Cross-Sectional, Observational Study

ChAdOx1-nCOV is safe with high seroconversion rates in patients with cirrhosis. Antibody response is not affected by the severity of liver disease.

verfasst von:
Amandeep Singh, Arka De, Mini P. Singh, Sahaj Rathi, Nipun Verma, Madhumita Premkumar, Sunil Taneja, Ajay Duseja, Virendra Singh

25.09.2022 | Multicenter Seminars: IBD (MUSE: IBD)

A Dancer with Fractures: What Lies Beneath?

A 34-year-old male was hospitalized with severe abdominal pain, non-bloody diarrhea and an intra-abdominal abscess adjacent to the terminal ileum that did not resolve with antibiotic therapy. He underwent an ileocecectomy, with pathology revealing …

verfasst von:
Samima Habbsa, Andrew Canakis, Lauren George, Afton Thomas, Yinin Hu, Raymond K. Cross, Hilary B. Whitlatch

25.09.2022 | Image of the Month

Cholangioscopy-Guided Surgical Clip Extraction During Giant Stone Lithotripsy

verfasst von:
Pedro López-Muñoz, María García-Campos, Vicente Lorenzo-Zúñiga, Noelia Alonso-Lázaro, Lidia Argüello, Marco Bustamante-Balén, Vicente Pons-Beltrán

25.09.2022 | Image of the Month

Interstitial Lung Disease, Intestinal Pseudo-obstruction, Biliary Tract Dilatation in a Patient with Sjogren’s Syndrome

verfasst von:
Xiaojun Mai, Jiajia Wu, Shuping Cai, Xiuji Huang, Hui Li, Canmao Xie

22.09.2022 | Image of the Month

Modified Percutaneous Endoscopic Gastrojejunostomy for Duodenal Fistula

verfasst von:
Juanjuan Zhang, Xiaoli Qian, Ming Duan, Yi Li, Zhiming Wang

21.09.2022 | Original Article

Band Ligation Can Be Used to Treat Barrett’s Esophagus and Concurrent Esophageal Varices: A Case Series

Barrett’s esophagus (BE) involves metaplasia in which the normal nonkeratinized stratified squamous epithelium of the distal esophagus is replaced by nonciliated columnar epithelium resembling intestinal epithelium [ 1 ]. BE is estimated to affect …

verfasst von:
Colin Hartgerink, Faisal M. Nimri, Tobias Zuchelli, Syed-Mohammed Jafri, Cyrus Piraka

20.09.2022 | Multicenter Seminars: IBD (MUSE: IBD)

An Old Bridge to the Newer Biologics: Cyclosporine for Rescue Therapy in Acute Severe Ulcerative Colitis

A 45-year-old man with an 11-year history of extensive ulcerative colitis (UC) was evaluated for acute severe UC (ASUC), manifest as increased stool frequency, urgency, hematochezia, and left-sided abdominal pain. He had previously been …

verfasst von:
Divya Ashat, Animesh Jain, Kimberly N. Weaver, Millie D. Long, Hans H. Herfarth, Edward L. Barnes

Open Access 20.09.2022 | Original Article

A Method Using Longitudinal Laboratory Data to Predict Future Intestinal Complication in Patients with Crohn’s Disease

Crohn’s disease is a chronic inflammatory condition of the human gastrointestinal tract of undetermined etiology. It is characterized by a relapsing and remitting course [ 1 ] and by significant morbidity from chronic abdominal pain, diarrhea …

verfasst von:
James Irwin, Anton Lord, Emma Ferguson, Lisa A. Simms, Katherine Hanigan, Carlos A. Montoya, Graham Radford-Smith

20.09.2022 | Stanford Multidisciplinary Seminars

Erasing Giant Folds: Ménétrier's Disease Treated with Cetuximab

A 65-year-old man was evaluated for complaints of diarrhea, loss of appetite, and substantial (25 lbs) unintentional weight loss over several months. His past medical history was unremarkable. On initial evaluation he appeared cachectic, weighing …

verfasst von:
Hannah Ramrakhiani, George Triadafilopoulos

Open Access 20.09.2022 | Original Article

Isolation and Characterization of Stem Cells from the Anal Canal Transition Zone in Pigs

Stem cell therapy is a promising approach to cure degenerative diseases and has been proposed for the treatment of various disease, including anal sphincter incontinence (ASI) [ 1 – 3 ]. Despite more than 20 years of research in this field with …

verfasst von:
Alexandre Balaphas, Jeremy Meyer, Nicolas C. Buchs, Ali Modarressi, Leo H. Bühler, Christian Toso, Carmen Gonelle-Gispert, Frédéric Ris

20.09.2022 | Stanford Multidisciplinary Seminars

Hiding in Planus Sight: Localized Ulcerative Jejunitis in a Patient with Celiac Disease

A 52-year-old woman with a history of hypothyroidism, celiac disease, and small bowel ulcerations was referred to Stanford Digestive Health for a tertiary opinion. She was initially evaluated in the Emergency Department of another hospital 9 …

verfasst von:
Wendy Zhou, George Triadafilopoulos, Nielsen Fernandez-Becker

20.09.2022 | Original Article

Stratification Based on Risk Factors at Diagnosis Could Predict Progression in Patients with Pancreatic Cysts

Pancreatic cysts, including branched duct intraductal papillary mucinous neoplasms (IPMNs), are common and often incidentally detected on medical imaging, such as computed tomography (CT) in 2.1% of cases [ 1 ] and magnetic resonance imaging (MRI) …

verfasst von:
Ryo Sugio, Tsutomu Nishida, Kengo Matsumoto, Kosuke Kawamura, Miyoung Park, Tomoya Hamabe, Kana Hosokawa, Shinji Kuriki, Li-sa Chang, Yoshifumi Fujii, Naoto Osugi, Aya Sugimoto, Kaori Mukai, Dai Nakamatsu, Shiro Hayashi, Masashi Yamamoto, Sachiko Nakajima, Koji Fukui, Masami Inada