The global rise of non-communicable diseases (NCDs) presents an urgent public health challenge, particularly in regions undergoing rapid economic and demographic transitions. Guangdong Province, China’s most populous and economically advanced …

Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy. While space–time clustering of ALL cases has been suggested, only one prior study has examined clustering by genetic subtype. We investigated space–time clustering of …

Mendelian randomization has emerged as a powerful tool for exploring causal relationships in observational studies by using genetic variants as instrumental variables. While multivariable Mendelian randomization extends this approach to …

Observational studies have linked maternal hormonal contraception use to childhood cancer risk, but findings are inconsistent. A systematic review was conducted of this potential relationship. A systematic search was performed in PubMed, Embase …

The Danish National Patient Registry (DNPR) and the Danish Cancer Registry (DCR) are central to registry-based cancer research. This systematic review evaluates studies assessing the quality of cancer-related data in these registries under their …

There is a high need for accurate prognostic models among stage II melanoma to determine who may benefit from (neo)adjuvant systemic therapy. The Dutch Early- Stage Melanoma (D-ESMEL) study was designed to identify new prognostic features in a …

Women with endometriosis have a higher burden of anxiety and depression. Whether they are at increased risk of postpartum depression (PPD) remains unclear. We aimed to compare the risk of PPD between women with and without endometriosis and to …

Age-related macular degeneration (AMD) is a leading cause of irreversible vision loss worldwide. However, evidence regarding the relationship between air pollution and AMD is limited, and the modifying effect of genetic susceptibility on this …

Machine learning (ML) algorithms are increasingly used to estimate propensity score with expectation of improving causal inference. However, the validity of data-driven ML-based approaches for confounder selection and adjustment remains unclear.

This study tests the “longevity hypothesis,” which posits that women’s greater number of years spent in poor health is primarily a direct consequence of their longer survival. We analyse gender differences in unhealthy life years (ULY) at age 50 …

Brain tumour is the second most common type of childhood cancer and the most common solid tumour in children, but its aetiology is largely unknown. Some previous studies have suggested that elevated ultraviolet radiation (UVR) exposures decrease …

Clinical trials have shown favorable effects of exercise on frailty, supporting physical activity (PA) as a treatment and prevention strategy. Proteomics studies suggest that PA alters levels of many proteins, some of which may function as …

The associations of coffee and tea intake with long-term risk of dementia have not been thoroughly established. Additionally, the potential mediating roles of circulating inflammatory biomarkers in these associations remain less explored. We …

Pro-inflammatory diets are associated with cognitive decline and dementia, but their impact on brain aging is unclear. We investigated the association between a pro-inflammatory diet and brain age, taking into account age, genetic risk for …

Purpose: To assess the validity of information on the date of diagnosis of intracranial tumors in the Swedish National Cancer Register. Materials and Methods: The study was conducted in Region Stockholm, covering approximately 2.4 million …

Since 2019, death data published by the Institute of Statistics and Economic Studies (INSEE) are available, raising questions regarding methodology and potential biases in overall survival analyses. We conducted a simulation study to quantify …

The co-occurrence of Hashimoto’s thyroiditis (HT) and Sjogren’s syndrome (SS), two seemingly unrelated diseases that both affect huge amounts of people worldwide, has been indicated previously in several case reports. However, there is a lack of …

Severe chronic disease (SCD) in childhood may hinder not only physical health but also academic performance. In this population-based cohort study, we investigated educational outcomes among 20,979 Danish children with SCD (54.7% male) and 423,814 …

Hematological neoplasms (HN) were the first cause of death in children aged 5–9 years in Spain. The aim of this registry-based study is to provide a detailed overview of the survival of HN in the Spanish pediatric population. All pediatric HN …