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Inflammopharmacology OnlineFirst articles

Open Access 23.04.2024 | Original Article

Combined effect of pantoprazole and mesenchymal stem cells on experimentally induced gastric ulcer: implication of oxidative stress, inflammation and apoptosis pathways

Gastric ulcer (GU) is one of the most common diseases of the upper gastrointestinal tract that affects millions of people worldwide. This study aimed to investigate the possible alleviating effect of a combined treatment of pantoprazole (PANTO) …

verfasst von:
Alaa H. Sayed, Nadia S. Mahmoud, Ola A. M. Mohawed, Hanaa H. Ahmed

23.04.2024 | Review

Neuroinflammation and the role of epigenetic-based therapies for Huntington’s disease management: the new paradigm

Huntington’s disease (HD) is an inherited, autosomal, neurodegenerative ailment that affects the striatum of the brain. Despite its debilitating effect on its patients, there is no proven cure for HD management as of yet. Neuroinflammation …

verfasst von:
Pooja Temgire, Richmond Arthur, Puneet Kumar

22.04.2024 | Original Article

Molecular insights of Eucalyptol (1,8-Cineole) as an anti-arthritic agent: in vivo and in silico analysis of IL-17, IL-10, NF-κB, 5-LOX and COX-2

The monoterpene oxide, Eucalyptol (1,8-Cineole), a primary component of eucalyptus oil, has been evaluated pharmacologically for anti-inflammatory and analgesic activity. Current research aimed to evaluate Eucalyptol’s anti-arthritic potential in …

verfasst von:
Urooj Iqbal, Abdul Malik, Nabeela Tabassum Sial, Ambreen Malik Uttra, Muhammad Fayyaz ur Rehman, Malik Hassan Mehmood

20.04.2024 | Original Article

Efficacy and safety of proton pump inhibitors on cardiovascular events and inflammatory factors in patients with upper gastrointestinal bleeding undergoing dual antiplatelet therapy

Dual antiplatelet therapy (DAPT) is commonly applied after percutaneous coronary intervention (PCI) to prevent cardiovascular events (CVEs). It involves the simultaneous use of two antiplatelet drugs to reduce platelet aggregation and prevent …

verfasst von:
Shuting Yang, Linni Shi

20.04.2024 | Original Article

Therapeutic effects and mechanisms of isoxanthohumol on DSS-induced colitis: regulating T cell development, restoring gut microbiota, and improving metabolic disorders

Ulcerative colitis (UC) is a severe hazard to human health. Since pathogenesis of UC is still unclear, current therapy for UC treatment is far from optimal. Isoxanthohumol (IXN), a prenylflavonoid from hops and beer, possesses anti-microbial …

verfasst von:
Ya-Na Yang, Bing Han, Mao-Qing Zhang, Na-Nan Chai, Feng-Lin Yu, Wen-Hui Qi, Meng-Yuan Tian, Dong-Zhi Sun, Ying Huang, Qing-Xin Song, Yan Li, Mao-Cui Zhu, Yuan Zhang, Xing Li

Open Access 17.04.2024 | Original Article

Neuroprotective effect of Withania somnifera leaves extract nanoemulsion against penconazole-induced neurotoxicity in albino rats via modulating TGF-β1/Smad2 signaling pathway

Penconazole (PEN) is a systemic triazole fungicide used to control various fungal diseases on grapes, stone fruits, cucurbits, and strawberries. Still, it leaves residues on treated crops after collection with many hazardous effects on population …

verfasst von:
Mohamed Abomosallam, Basma M. Hendam, Amr A. Abdallah, Rasha Refaat, Heba Nageh Gad EL-Hak

15.04.2024 | Original Article

Evaluating the docetaxel effect in an animal model of polyarthritis

Rheumatoid arthritis (RA) is a common immune-mediated inflammatory disease that mostly affects synovial joints. Immune cell infiltration of joints is a characteristic of rheumatoid arthritis (van Delft and Huizinga 2020 ). Which is characterized by …

verfasst von:
Omar Mustafa Alghulami, Ghaith Ali Jasim, Suzan Yousif Jasim

Open Access 15.04.2024 | Original Article

Impact of prior antihypertensive treatment on COVID-19 outcomes, by active ingredient

The COVID-19 pandemic has highlighted the need to ascertain the effects of the use of different chronic medications on susceptibility to and severity of COVID-19. Identification of drugs that are associated with an increased risk would make it …

verfasst von:
Rosa María García-Álvarez, Maruxa Zapata-Cachafeiro, Irene Visos-Varela, Almudena Rodríguez-Fernández, Samuel Pintos-Rodríguez, Maria Piñeiro-Lamas, Teresa M. Herdeiro, Adolfo Figueiras, Angel Salgado-Barreira, COVID-Drug Group

14.04.2024 | Review

Comparison of different sources of mesenchymal stem cells: focus on inflammatory bowel disease

Inflammatory bowel disease (IBD) poses a significant challenge in modern medicine, with conventional treatments limited by efficacy and associated side effects, necessitating innovative therapeutic approaches. Mesenchymal stem cells (MSC) have …

verfasst von:
Lihao Shi, Leilei Chen, Xizhuang Gao, Xufan Sun, Guiyuan Jin, Yonghong Yang, Yiming Shao, Fengqin Zhu, Guangxi Zhou

12.04.2024 | Original Article

Artemisia herba-alba: antioxidant capacity and efficacy in preventing chronic arthritis in vivo

Arthritis is a debilitating condition impacting the quality of life for millions worldwide, characterized by pain and inflammation. Understanding the mechanisms of arthritis and developing effective treatments are crucial. This study investigated …

verfasst von:
Hicham Wahnou, Martin Ndayambaje, Zaynab Ouadghiri, Salma Benayad, Hicham Elattar, Oumaima Chgari, Abdallah Naya, Younes Zaid, Mounia Oudghiri

06.04.2024 | Review

Evaluation of efficacy and safety of glucosamine sulfate, chondroitin sulfate, and their combination regimen in the management of knee osteoarthritis: a systematic review and meta-analysis

Osteoarthritis (OA) is a chronic, degenerative joint disease characterized by the gradual loss of articular cartilage in the synovial joints. It is caused by an imbalance between catabolic and anabolic processes, due to which the tissues in the …

verfasst von:
Anvita Rabade, Gollapalle Lakshminarayanashastry Viswanatha, Krishnadas Nandakumar, Anoop Kishore

06.04.2024 | Review

Atopic dermatitis: treatment and innovations in immunotherapy

Atopic dermatitis (AD) is a common inflammatory skin disease characterized by itching and skin barrier dysfunction. Moderate to severe AD is often refractory to first-line topical treatments, and systemic immunosuppressants have been shown to be …

verfasst von:
Francesco Ferrara, Andrea Zovi, Maurizio Capuozzo, Roberto Langella

Open Access 06.04.2024 | Original Article

Terminalia ferdinandiana Exell. extracts reduce pro-inflammatory cytokine and PGE2 secretion, decrease COX-2 expression and down-regulate cytosolic NF-κB levels

Based on their high antioxidant capacity and noteworthy phytochemistry, Terminalia ferdinandiana fruit and leaves have attracted considerable recent interest for their therapeutic potential. Whilst those studies have reported a variety of …

verfasst von:
Ian E. Cock

04.04.2024 | Original Article

Protective effects of sinomenine against dextran sulfate sodium-induced ulcerative colitis in rats via alteration of HO-1/Nrf2 and inflammatory pathway

The gastrointestinal tract (GIT) is mainly affected by ulcerative colitis (UC), a common inflammatory condition (Mahmoud et al. 2021 ). It is characterized by a chronic and relapsing pattern, often causing nonspecific yet severe effects on the …

verfasst von:
Zhongbao Niu, Xinhong Li, Xiuhua Yang, Zhongwei Sun

03.04.2024 | Review

Therapeutic effects of tetrandrine in inflammatory diseases: a comprehensive review

Inflammation can be triggered by any factor. The primary pathological manifestations can be summarized as the deterioration, exudation, and proliferation of local tissues, which can cause systemic damage in severe cases. Inflammatory lesions are …

verfasst von:
Jiawen Song, Yushi Liu, Yurou Guo, Minghao Yuan, Wenxiao Zhong, Jiamei Tang, Yiping Guo, Li Guo

03.04.2024 | Original Article

Physiological healing of chronic gastric ulcer is not impaired by the hydrogen sulphide (H2S)-releasing derivative of acetylsalicylic acid (ATB-340): functional and proteomic approaches

Gastric ulcers affect approx. 10% of population. Non-steroidal anti-inflammatory drugs (NSAIDs), including acetylsalicylic acid (ASA) predispose to or impair the physiologically complex healing of pre-existing ulcers. Since H2S is an endogenous …

verfasst von:
Edyta Korbut, Maciej Suski, Zbigniew Śliwowski, Dominik Bakalarz, Urszula Głowacka, Dagmara Wójcik-Grzybek, Grzegorz Ginter, Kinga Krukowska, Tomasz Brzozowski, Marcin Magierowski, John L. Wallace, Katarzyna Magierowska

02.04.2024 | Original Article

In-vitro antioxidant and anti-inflammatory potential along with p.o. pharmacokinetic profile of key bioactive phytocompounds of Snow Mountain Garlic: a comparative analysis vis-à-vis normal garlic

Snow mountain garlic (SMG) is a trans-Himalayan medicinal plant used in the traditional medicine system for several ailments, including inflammatory arthritis. Research studies are insufficient to validate its folk medicinal applications. In the …

verfasst von:
Bhupinder Kaur, Nitish Kumar, Laxmi Kumari, Ajai P. Gupta, Rajni Sharma, Kanwaljit Chopra, Shweta Saxena

Open Access 02.04.2024 | Original Article

Autophagy and exosomes; inter-connected maestros in Alzheimer’s disease

Autophagy is a crucial process involved in the degradation and recycling of cytoplasmic components which are transported to the lysosomal compartment by autophagosomes. Exosomes are an important means of communication and signaling in both normal …

verfasst von:
Hanaa B. Atya, Nadia Mohamed Sharaf, Ragwa Mansour Abdelghany, Sara Nageeb El-Helaly, Heba Taha

31.03.2024 | Original Article

Anti-gouty arthritis and anti-inflammatory effects of curcumin nanoparticles in monosodium urate crystals induced Balb/C mice

Gout is a metabolic condition characterized by the accumulation of urate crystals in the synovial joints. These crystal depositions result in joint swelling and increased concentration of serum uric acid in blood. The commercially available drugs …

verfasst von:
Chanda Javed, Razia Noreen, Samia gul Niazi, Mubin Mustafa Kiyani, Qurat Ul Ain

Open Access 25.03.2024 | Review

Pathophysiology, diagnosis, and herbal medicine-based therapeutic implication of rheumatoid arthritis: an overview

Rheumatoid arthritis (RA) stands as an autoimmune disorder characterized by chronic joint inflammation, resulting in profound physiological alterations within the body. Affecting approximately 0.4–1.3% of the global population, this condition …

verfasst von:
Charanjit Kaur, Yachana Mishra, Rajesh Kumar, Gurvinder Singh, Sukhraj Singh, Vijay Mishra, Murtaza M. Tambuwala