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Inflammopharmacology OnlineFirst articles

19.02.2024 | Review

The effects of silymarin consumption on inflammation and oxidative stress in adults: a systematic review and meta-analysis

Oxidative stress is tissue damage caused by the uncontrolled production of pro-oxidant free radicals. This damage can be structural or functional (Ďuračková 2010 ; Hussain et al. 2016 ; Radi et al. 2014 ). When cells and tissues produce reactive …

verfasst von:
Hossein Bahari, Mostafa Shahraki Jazinaki, Mohammad Rashidmayvan, Shaghayegh Taheri, Mohammad Reza Amini, Mahsa Malekahmadi

19.02.2024 | Original Article

Glabridin reduces neuroinflammation by modulating inflammatory signals in LPS-induced in vitro and in vivo models

Neuroinflammation, which is more common in the central nervous system (CNS), is a complicated response that encompasses multiple stages and is brought on by the loss of nerve cells in the brain. These responses can include autoimmune activity …

verfasst von:
Jiyu Weng, Ying Wang, Zekai Tan, Yanghe Yuan, Shiyuan Huang, Zexi Li, Yiming Li, Lanyue Zhang, Zhiyun Du

17.02.2024 | Original Article

Ameliorative effects of Atriplex crassifolia (C.A.Mey) on pain and inflammation through modulation of inflammatory biomarkers and GC–MS-based metabolite profiling

Atriplex crassifolia (A. crassifolia) is a locally occurring member of Chenopodiaceae family that has been used in folk medicine for the treatment of joint pain and inflammation. The present study was focused to determine the analgesic and …

verfasst von:
Sarah Rehman, Saiqa Ishtiaq, Muhammad Khalil-Ur-Rehman, Sairah Hafeez Kamran

16.02.2024 | Original Article

Association of statin use with osteoporosis risk: a drug-targeted Mendelian randomization study

Due to the growing elderly population, primary osteoporosis is rapidly becoming an important health challenge (Arundel and Bishop 2015 ). At present, tens of millions of people have suffered from this disease all around the world (Sarafrazi et al.

verfasst von:
Zhaozhou Ren, Long Zhou

13.02.2024 | Original Article

Flavipin from fungi as a potential inhibitor of rheumatoid arthritis signaling molecules

Flavipin, a fungal lower molecular weight biomolecule (MW 196.16 g/mol), has not been yet extensively studied for beneficial preclinical and clinical applications. In recent years, various preclinical mouse models including adjuvant-induced …

verfasst von:
Emad A. Ahmed, Abdulaah M. Alzahrani, Salah A. Abdelsalam, Hairul-Islam M. Ibrahim

12.02.2024 | Review

Role of corticosteroids in the treatment of critically ill sepsis patients: a meta-analysis review

Sepsis is caused by infection of the human body with pathogenic microorganisms such as bacteria that cause an inflammatory response (Esposito et al. 2017 ). In addition to the manifestations of systemic inflammatory response syndrome and primary …

verfasst von:
Yutong Song, Jing Hao, Yanhua Liu

12.02.2024 | Original Article

Does non-steroidal anti-inflammatory drugs-related preemptive analgesia modulate SOCS3/IL-6 pathway in oral surgery?

The dental surgeon performs several surgical procedures that tend to significantly affect the patient's quality of life in the postoperative period; surgery of the mandibular third molars is a standard procedure that substantially involves the …

verfasst von:
Assis Filipe Medeiros Albuquerque, José Jackson do Nascimento Costa, José Roberto Viana Silva, Paulo Goberlânio de Barros Silva, Filipe Nobre Chaves, Eduardo Frederico Eduardo Maferano, Edson Luiz Cetira Filho, Karuza Maria Alves Pereira, Sérgio Lima Santiago, Thyciana Rodrigues Ribeiro, Fábio Wildson Gurgel Costa

09.02.2024 | Original Article

Isolation, invitro, invivo anti-inflammatory, analgesic and antioxidant potential of Habenaria plantegania Lindl

Habenaira plantaginea belong to orchid family which is native to Asia. Members of this family are commonly famous for the cure of pain and inflammation. To date, no research was found on isolation of compounds from this plant for the treatment of …

verfasst von:
Osama M. Alshehri, Madeeha Shabnam, Saeed Ahmed Asiri, Mater H. Mahnashi, Abdul Sadiq, Muhammad Saeed Jan

Open Access 08.02.2024 | Original Article

Evaluation of the biological efficiency of Terminalia chebula fruit extract against neurochemical changes induced in brain of diabetic rats: an epigenetic study

Diabetes mellitus (DM) is a chronic and progressive metabolic disorder that can stimulate neuroinflammation and increase oxidative stress in the brain. Therefore, the present study was aimed to assess the efficacy of ethanolic Terminalia chebula …

verfasst von:
Marwa E. A. El-Shamarka, Wael Mahmoud Aboulthana, Nagwa Ibrahim Omar, Marwa M. Mahfouz

08.02.2024 | Review

A systematic review of interleukin-31 inhibitors in the treatment of prurigo nodularis

Prurigo nodularis (PN) is a chronic, disabling, neuroimmunological skin disease characterized by the severe itch and symmetric dissemination of multiple hyperkeratotic, firm nodules and repetitious scratching, rubbing, and stinging (Zeidler et al.

verfasst von:
Mohammad Ali Nilforoushzadeh, Nazila Heidari, Yekta Ghane, Amirhossein Heidari, Arman Hajikarim-Hamedani, SeyedAyin Hosseini, Fariba Jaffary, Minou Najar Nobari, Pegah Tavakolzadeh, Niloufar Najar Nobari

06.02.2024 | Original Article

Phytochemical analysis and immunomodulatory activities in vitro and in vivo of Aframomum melegueta K Schum seed extracts

Aframomum melegueta K Schum (A. melegueta), an herbaceous plant renowned for its medicinal seeds, was investigated for its potential immunomodulatory effects in vitro and in vivo using ethanolic and methanolic extracts. The immunomodulatory effect …

verfasst von:
Mounia Latif, Ismail Elkoraichi, Othman El Faqer, Hicham Wahnou, El Mostafa Mtairag, Mounia Oudghiri, Samira Rais

06.02.2024 | Original Article

The effects of probiotic supplements on oxidative stress and inflammation in subjects with mild and moderate Alzheimer’s disease: a randomized, double-blind, placebo-controlled study

Through modulating effects on the gut-brain axis, probiotics are an effective adjuvant treatment for Alzheimer’s disease (AD), one of our century’s most important medical care challenges (Agahi et al. Front Neurol 9:662, 2018). This trial aimed to …

verfasst von:
Camellia Akhgarjand, Zahra Vahabi, Sakineh Shab-Bidar, Aliarash Anoushirvani, Kurosh Djafarian

Open Access 04.02.2024 | Original Article

Leaf extracts of eight selected southern African medicinal plants modulate pro-inflammatory cytokine secretion in LPS-stimulated RAW 264.7 macrophages

This study investigates the anti-inflammatory properties of extracts prepared from the leaves of eight southern African medicinal plants used traditionally to treat inflammation and pain. The inhibitory effect of aqueous and ethanol extracts on …

verfasst von:
Gugulethu P. Khumalo, Wendy Loa-Kum-Cheung, Ben-Erik Van Wyk, Yunjiang Feng, Ian E. Cock

03.02.2024 | Original Article

Observational analysis of the immunogenicity and safety of various types of spinal muscular atrophy vaccines

Spinal muscular atrophy (SMA) is a common acute enteric infectious disease primarily transmitted via the fecal–oral route. The infection of SMA can be classified into type I, type II, and type III (Chumakovet al. 2021 ; Tseha 2021 ). SMA is caused …

verfasst von:
Guojuan Sun, Guangzhi Wang, Heng Zhong

03.02.2024 | Original Article

Neuroprotective mechanism of trans,trans-Farnesol in an ICV-STZ-induced rat model of Alzheimer’s pathology

Alzheimer disease is one of the most progressive neurodegenerative diseases, causing a significant public health burden in both developing and developed nations globally. In accordance with research from the Alzheimer’s Association, one in nine …

verfasst von:
Monika Kadian, Neetu Saini, Alka Khera, Anil Kumar

03.02.2024 | Original Article

Quercetin attenuates Pseudomonas aeruginosa-induced acute lung inflammation by inhibiting PI3K/AKT/NF-κB signaling pathway

Pseudomonas aeruginosa is an opportunistic pathogen that commonly causes infections in immunocompromised individuals with significant morbidity and mortality. Quercetin is a natural flavonoid abundantly present in fruits and vegetables, exerting …

verfasst von:
Xiaolei Jia, Mengdi Gu, Jiangqin Dai, Jue Wang, Yingying Zhang, Zheng Pang

03.02.2024 | Original Article

D-limonene inhibits peritoneal adhesion formation in rats via anti-inflammatory, anti-angiogenic, and antioxidative effects

The aim of this research was to investigate the effects of d-limonene on decreasing post-operative adhesion in rats and to understand the mechanisms involved. Peritoneal adhesions were induced by creating different incisions and excising a 1 × 1 …

verfasst von:
Ali Razazi, Ali Kakanezhadi, Abbas Raisi, Behnam Pedram, Omid Dezfoulian, Farshid Davoodi

03.02.2024 | Original Article

Phytochemical profiling, antioxidant, cytotoxic, and anti-inflammatory activities of Plectranthus rugosus extract and fractions: in vitro, in vivo, and in silico approaches

Inflammation occurs when cells in an organism respond to a threat, such as an infection or tissue injury, by producing inflammatory cytokines. It seeks to get rid of pathogens, pinpoint the damage, and get normal tissue function back (Chen et al.

verfasst von:
Reyaz Hassan Mir, Roohi Mohi-ud-din, Lamya Ahmed Al-Keridis, Bilal Ahmad, Nawaf Alshammari, Mitesh Patel, Mohd Adnan, Mubashir Hussain Masoodi

Open Access 31.01.2024 | Review Article

Repurposing metformin to manage idiopathic or long COVID Tinnitus: self-report adopting a pathophysiological and pharmacological approach

Chronic tinnitus is a common neurological disorder that affects millions of patients globally with no available successful pharmacotherapy. It can be extremely bothersome to some patients to the extent that it occasionally qualifies as a …

verfasst von:
Mina T. Kelleni

Open Access 31.01.2024 | Original Article

Neuroprotective potential of Erigeron bonariensis ethanolic extract against ovariectomized/D-galactose-induced memory impairments in female rats in relation to its metabolite fingerprint as revealed using UPLC/MS

Erigeron bonariensis is widely distributed throughout the world's tropics and subtropics. In folk medicine, E. bonariensis has historically been used to treat head and brain diseases. Alzheimer’s disease (AD) is the most widespread form of …

verfasst von:
Weam W. Ibrahim, Rabab H. Sayed, Mohamed F. Abdelhameed, Enayat A. Omara, Mahmoud I. Nassar, Noha F. Abdelkader, Mohamed A. Farag, Abdelsamed I. Elshamy, Sherif M. Afifi