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Inflammopharmacology OnlineFirst articles

Open Access 07.11.2023 | Original Article

Comprehensive phytochemical characterization of Persea americana Mill. fruit via UPLC/HR-ESI–MS/MS and anti-arthritic evaluation using adjuvant-induced arthritis model

Persea americana Mill. (avocado fruit) has many health benefits when added to our diet due to various pharmacological activities, such as preventing bone loss and inflammation, modulating immune response and acting as an antioxidant. In the …

verfasst von:
Dina Atef Waly, Aisha Hussein Abou Zeid, Hanan Naeim Attia, Kawkab A. Ahmed, El-Sayeda Ahmed El-Kashoury, Ali Mahmoud El Halawany, Reda Sayed Mohammed

04.11.2023 | Review

Targeting memory loss with aspirin, a molecular mechanism perspective for future therapeutic approaches

Acetylsalicylic acid (ASA), also known as aspirin, was discovered in 1897 as an acetylated form of salicylate. It has been widely used for its anti-inflammatory and antiplatelet effects. It is commonly used for its cardiovascular benefits and is …

verfasst von:
Masoumeh Gholami, Mehdi Sadegh, Masoumeh Koroush-arami, Shaghayegh Norouzi, Rasoul Jafari Arismani, Erfan Asadi, Mohammad Amini, Nahid Khodayari

03.11.2023 | Original Article

Effect of nitro-conjugated linoleic acid on the inflammatory response of murine macrophages activated with lipopolysaccharide derived from Prevotella intermedia

Nitro-conjugated linoleic acid (NO2-CLA) has been observed to manifest salutary signaling responses, including anti-inflammatory and antioxidant properties. Here, the authors have explored the influence and underlying mechanisms of NO2-CLA on the …

verfasst von:
Jung Eun Lee, Ah Rim Lee, Eun-Young Choi, In Soon Choi, Sung-Jo Kim

03.11.2023 | Review

Plant-based green synthesis of nanoparticles as an effective and safe treatment for gastric ulcer

Gastric ulcer is a chronic disease that affects about 10% of the world’s population. This disease is caused by factors such as stress, smoking, alcohol consumption, nonsteroidal anti-inflammatory drugs (NSAIDs), Helicobacter pylori infection, and …

verfasst von:
Seifollah Bahramikia, Rezvan Izadi

Open Access 30.10.2023 | Original Article

Management of ulcerative colitis by dichloroacetate: Impact on NFATC1/NLRP3/IL1B signaling based on bioinformatics analysis combined with in vivo experimental verification

The inflammatory response in ulcerative colitis (UC) could be relieved by the conventional immunomodulatory agents; 5-aminosalicylic acid, corticosteroids, or azathioprine. However, the low remission rates and the intolerance to these agents …

verfasst von:
Esraa Abdel-Nassir Abdel-Razek, Heba M. Mahmoud, Amany A. Azouz

Open Access 24.10.2023 | Review

Innovative preconditioning strategies for improving the therapeutic efficacy of extracellular vesicles derived from mesenchymal stem cells in gastrointestinal diseases

Gastrointestinal (GI) diseases have become a global health issue and an economic burden due to their wide distribution, late prognosis, and the inefficacy of recent available medications. Therefore, it is crucial to search for new strategies for …

verfasst von:
Manar A. Didamoony, Ayman A. Soubh, Ahmed M. Atwa, Lamiaa A. Ahmed

21.10.2023 | Original Article

Attenuation of CFA-induced arthritis through regulation of inflammatory cytokines and antioxidant mechanisms by Solanum nigrum L. leaves extracts

Solanum nigrum L. is a popular traditional medicine for various inflammatory conditions including rheumatism and joint pain. The current study aimed to evaluate the anti-arthritic mechanism of Solanum nigrum L. Four extracts were prepared using …

verfasst von:
Bazgha Gul, Rukhsana Anwar, Mohammad Saleem, Mobasher Ahmad, Muhammad Ihsan Ullah, Shahzad Kamran

21.10.2023 | Original Article

2-Hydroxybenzohydrazide as a novel potential candidate against nociception, inflammation, and pyrexia: in vitro, in vivo, and computational approaches

The current study was designed to evaluate the 2-hydroxybenzohydrazide (HBH) as a drug having efficacy against pyrexia, inflammation, and nociception. Besides, the therapeutic effects of HBH on oxidative stress and C-reactive proteins were also …

verfasst von:
Gowhar Ali, Nazar Ul Islam, Muhammad Qaim, Rahim Ullah, Muhammad Saeed Jan, Khadija Shabbiri, Muhammad Shafique, Muhammad Ayaz

19.10.2023 | Original Article

Anti-inflammatory activity of peiminine in acetic acid-induced ulcerative colitis model

Ulcerative colitis is a chronic inflammatory disorder of the intestinal mucosa and a prevalent gastrointestinal condition in developed countries. Peiminine, derived from the Fritillaria imperialis plant, exhibits remarkable anti-inflammatory and …

verfasst von:
Maryam Ranjbar Bushehri, Nahid Babaei, Hadi Esmaeili Gouvarchin Ghaleh, Gholamreza Khamisipour, Gholamreza Farnoosh

Open Access 19.10.2023 | Original Article

Potential role of SNP rs2071475 in rheumatoid arthritis and inflammatory bowel disease in the East Asian population: a Mendelian randomization study

Rheumatoid arthritis (RA) is a chronic inflammatory joint disease of unknown etiology, which can result in cartilage and skeletal damage, as well as disability. Although primarily affecting the joints, RA should be regarded as a syndrome …

verfasst von:
Bo Wang, Yongqiang Xiong, Ren Li, Shu Zhang

17.10.2023 | Original Article

Efficacy and safety of licorice (Glycyrrhiza glabra) in moderately ill patients with COVID-19: a randomized controlled trial

Licorice extract (glycyrrhizin), a potent antiviral, anti-inflammatory, and antioxidant remedy, is a potential therapeutic option for COVID-19. We evaluated the efficacy and safety of licorice in patients with moderate COVID-19. In this study, 60 …

verfasst von:
Ali Ameri, Mehdi Farashahinejad, Parivash Davoodian, Omid Safa, Amin Kusha, Habib Dadvand, Soheil Hassanipour, Mohammad Fathalipour

17.10.2023 | Original Article

Protective effect of olopatadine hydrochloride against LPS-induced acute lung injury: via targeting NF-κB signaling pathway

The acute respiratory distress syndrome (ARDS) is a more severe manifestation of acute lung injury (ALI) (ARDS). ALI or ARDS is an important cause of mortality in the human population and continues to be a significant challenge for the critical …

verfasst von:
Jaspreet Kaur, Priyanka Rana, Tushar Matta, Rupinder Kaur Sodhi, Khushboo Pathania, Sandip V. Pawar, Anurag Kuhad, Kanthi Kiran Kondepudi, Tanzeer Kaur, Neelima Dhingra, Sangeeta Pilkhwal Sah

Open Access 17.10.2023 | Original Article

Sesamol defends neuronal damage following cerebral ischemia/reperfusion: a crosstalk of autophagy and Notch1/NLRP3 inflammasome signaling

Cardiac arrest is considered a significant risk factor for global cerebral ischemia, as it leads to the cessation of cerebral blood flow. The brain tissue exhibits a high degree of sensitivity to ischemia, wherein even short periods of ischemia in …

verfasst von:
Shorouk Mohamed El-Sayyad, Dina M. Abo El-Ella, Mohamed M. Hafez, Asmaa K. Al-Mokaddem, Bassam Mohamed Ali, Magdy M. Awny, Soad Z. El-Emam

17.10.2023 | Short Communication

The effect of probiotics on the risk of mortality in patients with COVID-19: systematic review and meta-analysis of randomized trials

Probiotics have been hypothesized to play a beneficial role in modulating immune responses and gut microbiota in various clinical settings. This systematic review and meta-analysis aimed to assess the effectiveness of probiotics in reducing …

verfasst von:
Chia Siang Kow, Dinesh Sangarran Ramachandram, Syed Shahzad Hasan

16.10.2023 | Original Article

Systems pharmacology and multi-scale mechanism of Enicostema axillare bioactives in treating Alzheimer disease

As a progressive neurological disease with increased morbidity and mortality, Alzheimer Disease (AD) is characterized by neuron damage that controls memory and mental functions. Enicostema axillare (EA), an herb with a history of combativeness and …

verfasst von:
Madhana Vigneshwari Gopal Samy, Sasidharan Perumal

16.10.2023 | Original Article

The efficacy of thymosin alpha-1 therapy in moderate to critical COVID-19 patients: a systematic review, meta-analysis, and meta-regression

Coronavirus disease 2019 (COVID-19) is still a global health challenge, even more than 3 years since its first appearance at the end of 2019 (The Lancet 2023 ). Nearly 7 million people have died as a result of the severe acute respiratory …

verfasst von:
Arto Yuwono Soeroto, Hendarsyah Suryadinata, Theo Audi Yanto, Timotius Ivan Hariyanto

16.10.2023 | Review

A narrative review of the effects of dexamethasone on traumatic brain injury in clinical and animal studies: focusing on inflammation

Traumatic brain injury (TBI) is a type of brain injury resulting from a sudden physical force to the head. TBI can range from mild, such as a concussion, to severe, which might result in long-term complications or even death. The initial impact or …

verfasst von:
Afsaneh Soltani, Uliana Y. Chugaeva, Montather F. Ramadan, Ebraheem Abdu Musad Saleh, Shaker Shanawa Al-Hasnawi, Rosario Mireya Romero-Parra, Ali Alsaalamy, Yasser Fakri Mustafa, Mohammad Yasin Zamanian, Maryam Golmohammadi

13.10.2023 | Review

Pro-resolving and anti-inflammatory effects of resolvins and protectins in rheumatoid arthritis

Rheumatoid arthritis (RA) is typified by persistent joint inflammation, which leads to the deterioration of bone and cartilage and a reduction in overall quality of life. The global prevalence of pain as a primary symptom in RA is influenced by …

verfasst von:
Xiurong Zhang, Hongting Zhang

13.10.2023 | Commentary

Cytokine profiles in COVID-19 patients undergoing adjunct ozone therapy: some comments

A comment to: Ghaleh HEG, Izadi M, Javanbakht M, Ghanei M, Einollahi B, Jafari NJ, Alishiri G, Aslani J, Abolghasemi H, Simonetti V, Khafaei M, Zhao S, Saadat SH, Ahmadi M, Parvin S, Vazifedoust S, Alvanagh AG. Cytokine profile and antioxidants …

verfasst von:
Salvatore Chirumbolo, Sergio Pandolfi, Marianno Franzini, Luigi Valdenassi

12.10.2023 | Original Article

Development of gel containing Psidium glaziovianum essential oil has in vitro antimicrobial activity and improves healing of excisional wounds in mice

Wounds encompass physical, chemical, biological, induced damages to the skin or mucous membranes. In wound treatment, combating infections is a critical challenge due to their potential to impede recovery and inflict systemic harm on patients.

verfasst von:
Wêndeo Kennedy Costa, Valquíria Bruna Guimarães, Beatriz Meyruze Barros da Fonsêca, Magda Rhayanny Assunção Ferreira, Luiz Alberto Lira Soares, Thiago Henrique Napoleão, Patrícia Maria Guedes Paiva, Maria Tereza dos Santos Correia, Fábio André Brayner dos Santos, Alisson Macário de Oliveira, Márcia Vanusa da Silva