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Inflammopharmacology OnlineFirst articles

15.12.2023 | Short Communication

Malvidin alleviates LPS-induced septic intestinal injury through the nuclear factor erythroid 2-related factor 2/reactive oxygen species/NLRP3 inflammasome pathway

Emerging evidence suggests that the gastrointestinal tract plays a crucial role in the pathophysiology of sepsis, a leading cause of mortality among patients admitted to the intensive care unit (ICU). Malvidin, belonging to the flavonoid family of …

verfasst von:
Guanglu Wang, Fenfen Ma, Wei Zhang, Yue Xin, Kaixin Ping, Yan Wang, Jingquan Dong

14.12.2023 | Original Article

Inhibition of TLR4, NF-κB, and INOS pathways mediates ameliorative effect of syringic acid in experimental ulcerative colitis in rats

The two most prevalent forms of inflammatory bowel disease (IBD) are ulcerative colitis (UC) and Crohn’s disease (CD) (Tekeli et al. 2019 ). In UC, the inflammation covers the entire colon and rectum and is associated with severe colonic mucosal …

verfasst von:
Maryam Ghasemi-Dehnoo, Hossein Amini-Khoei, Zahra Lorigooini, Maryam AnjomShoa, Elham Bijad, Mahmoud Rafieian-Kopaei

14.12.2023 | Review

Intravenous immunoglobulin for treatment of hospitalized COVID-19 patients: an evidence mapping and meta-analysis

Coronavirus disease 2019 (COVID-19) was declared a global pandemic by the World Health Organization (WHO) in March 2020. As of 10 February 2023, more than 755 million confirmed cases and 6.8 million deaths have been reported by the WHO (World …

verfasst von:
Mei-xuan Li, Yan-fei Li, Xin Xing, Jun-qiang Niu, Liang Yao, Meng-ying Lu, Ke Guo, Mi-na Ma, Xiao-tian Wu, Ning Ma, Dan Li, Zi-jun Li, Ling Guan, Xiao-man Wang, Bei Pan, Wen-ru Shang, Jing Ji, Zhong-yang Song, Zhi-ming Zhang, Yong-feng Wang, Ke-hu Yang

12.12.2023 | Review

Targeting cardiovascular risk factors with eugenol: an anti-inflammatory perspective

Inflammation is a multifaceted biological reaction to a wide range of stimuli, and it has been linked to the onset and progression of chronic diseases such as heart disease, cancer, and diabetes. Inflammatory markers found in the blood, including …

verfasst von:
Sushma Devi, Samrat Chauhan, Ashi Mannan, Thakur Gurjeet Singh

08.12.2023 | Commentary

Using aspirin to prevent and treat cancer

This review will discuss evidence that aspirin possesses anticancer activity. Long-term observational retrospective studies on nurses and health professionals demonstrated that regular aspirin users had a significantly lower incidence of …

verfasst von:
Lenard M. Lichtenberger

07.12.2023 | Review

Natural agents as wound-healing promoters

As the integumentary system, the skin is the largest and most exposed organ of the human body, performing a wide range of functions. It comprises multiple layers that serve as a protective barrier, shielding the body against various environmental …

verfasst von:
Negin Akhtari, Mahnaz Ahmadi, Yasaman Kiani Doust Vaghe, Elham Asadian, Sahar Behzad, Hossein Vatanpour, Fatemeh Ghorbani-Bidkorpeh

07.12.2023 | Original Article

Assessment of antiarthritic potential of Asparagus dumosus using formaldehyde and CFA-induced arthritic models in rats via modulation of oxidative stress biomarkers and mRNA expression of IL-1b, IL-6, RANKL, OPG, TNF-α and COX-2

Medicinal plants play a pivotal role in the prevention of chronic non-communicable diseases including arthritis. Despite the traditional use of Asparagus dumosus in arthritis, it has not been studied yet for its effectiveness in arthritis. This …

verfasst von:
Nimra Nazar, Malik Hassan Mehmood, Rida Siddique, Muhammad Naeem Faisal

Open Access 02.12.2023 | Original Article

Resveratrol protects against Schistosoma mansoni-induced liver fibrosis by targeting the Sirt-1/NF-κB axis

Hepatic schistosomiasis is a prevalent form of chronic liver disease that drastically affects human health. Nevertheless, an antifibrotic drug that could suppress the development of hepatic fibrosis does not exist yet. The current study aimed to …

verfasst von:
Dalia Kamal Mostafa, Maha M. Eissa, Doaa A. Ghareeb, Shaymaa Abdulmalek, Wafaa A. Hewedy

Open Access 01.12.2023 | Original Article

Empagliflozin repurposing in Parkinson’s disease; modulation of oxidative stress, neuroinflammation, AMPK/SIRT-1/PGC-1α, and wnt/β-catenin pathways

Parkinson's disease is a neuroprogressive disorder characterized by loss of dopaminergic neurons in substantia nigra pars compacta. Empagliflozin (EMPA), a SGLT-2 inhibitor, is an oral hypoglycemic agent with reported anti-inflammatory and …

verfasst von:
Noha Nabil Mohammed, Mariane G. Tadros, Mina Y. George

Open Access 27.11.2023 | Review

Therapeutic potential and possible mechanisms of ginseng for depression associated with COVID-19

Recently, a global outbreak of COVID-19 has rapidly spread to various national regions. As the number of COVID-19 patients has increased, some of those infected with SARS-CoV-2 have developed a variety of psychiatric symptoms, including …

verfasst von:
Fangyi Zhao, Kai Zhang, Hongyu Chen, Tianqi Zhang, Jiayu Zhao, Qianyu Lv, Qin Yu, Mengyu Ruan, Ranji Cui, Bingjin Li

Open Access 24.11.2023 | Original Article

Ibuprofen inhibits anaplastic thyroid cells in vivo and in vitro by triggering NLRP3-ASC-GSDMD-dependent pyroptosis

Pyroptosis is a novel type of proinflammatory programmed cell death that is associated with inflammation, immunity, and cancer. Anaplastic thyroid carcinoma (ATC) has a high fatality rate, and there is no effective or standard treatment. The …

verfasst von:
Haohao Guo, Runsheng Ma, Yifei Zhang, Keyu Yin, Gongbo Du, Fanxiang Yin, Hongqiang Li, Ziyang Wang, Detao Yin

23.11.2023 | Original Article

Liensinine reduces acute lung injury brought on by lipopolysaccharide by inhibiting the activation of the NF-κB signaling pathway through modification of the Src/TRAF6/TAK1 axis

ALI is characterized by macrophage-driven inflammation, causing severe lung damage. Currently, there are limited therapeutic options available for ALI. Liensinine (LIEN), with known anti-inflammatory properties, lacks extensive study in the ALI …

verfasst von:
Huizhen Chen, Feixue Liu, Dapeng Dai, Yuanyuan Ming, Yao Xu, Zhengqian Huang, Le Zhang, Yong Sun

Open Access 23.11.2023 | Original Article

L-Carnitine augments probenecid anti-inflammatory effect in monoiodoacetate-induced knee osteoarthritis in rats: involvement of miRNA-373/P2X7/NLRP3/NF-κB milieu

Osteoarthritis (OA) is a degenerative joint disease, whereas the underlying molecular trails involved in its pathogenesis are not fully elucidated. Hence, the current study aimed to investigate the role of miRNA-373/P2X7/NLRP3/NF-κB trajectory in …

verfasst von:
Rawan Mahfouz, Safaa H. El-Rewini, Asser I. Ghoneim, Eman Sheta, Mennatallah A. Ali, Sherihan Salaheldin Abdelhamid Ibrahim

23.11.2023 | Original Article

Synthesis of novel nonsteroidal anti-inflammatory galloyl β-sitosterol-loaded lignin-capped Ag-based drug

Biocompatible anti-inflammatory lignin-capped Ag (LCAg) nanoparticles (NPs) were synthesized for the delivery of galloyl β-sitosterol (Galloyl-BS). β-Sitosterol (BS) is effective against inflammatory responses, like cancer-induced inflammations.

verfasst von:
Sana Malik, Batool Fatima, Dilshad Hussain, Muhammad Imran, Tahir Ali Chohan, Muhammad Saqib Khan, Saadat Majeed, Muhammad Najam-ul-Haq

22.11.2023 | Review

Linking NLRP3 inflammasome and pulmonary fibrosis: mechanistic insights and promising therapeutic avenues

Pulmonary fibrosis is a devastating disorder distinguished by redundant inflammation and matrix accumulation in the lung interstitium. The early inflammatory cascade coupled with recurring tissue injury orchestrates a set of events marked by …

verfasst von:
Shobhit Gairola, Antarip Sinha, Ravinder K. Kaundal

20.11.2023 | Original Article

Synthesis, molecular docking, analgesic, anti-inflammatory, and ulcerogenic evaluation of thiophene-pyrazole candidates as COX, 5-LOX, and TNF-α inhibitors

The thiophene bearing pyrazole derivatives (7a-j) were synthesized and examined for their in vitro cyclooxygenase, 5-lipoxygenase, and tumour inducing factor-α inhibitory activities followed by the in vivo analgesic, anti-inflammatory, and …

verfasst von:
M. J. Nagesh Khadri, Ramith Ramu, N. Akshaya Simha, Shaukath Ara Khanum

16.11.2023 | Correction

Correction: Cardiovascular effect of inflammation and nonsteroidal anti-inflammatory drugs on renin–angiotensin system in experimental arthritis

verfasst von:
Waheed Asghar, Ali Aghazadeh-Habashi, Fakhreddin Jamali

15.11.2023 | Review

Nigella sativa and its chemical constituents: pre-clinical and clinical evidence for their potential anti-SARS-CoV-2 effects

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused over 500 million reported cases of COVID-19 worldwide with relatively high morbidity and mortality. Although global vaccination drive has helped control the pandemic, the …

verfasst von:
Asha Caroline Cyril, Najma Mohamed Ali, Anagha Nelliyulla Parambath, Cijo George Vazhappilly, Reem Kais Jan, Noushad Karuvantevida, Haneen Aburamadan, Yosra Lozon, Rajan Radhakrishnan

14.11.2023 | Original Article

Anti-inflammatory potential of some eudesmanolide and guaianolide sesquiterpenes

Ten sesquiterpene lactones isolated from Anvillea garcinii (Burm.f.) DC ethanolic extract were assessed for their anti-inflammatory potential by myeloperoxidase (MPO) activity assignment, and mice paw swelling model.

verfasst von:
Shagufta Perveen, Azadeh Hamedi, Ardalan Pasdaran, Reza Heidari, Muhammad Shafiq ul Azam, Sobia Tabassum, Rashad Mehmood, Jiangnan Peng

13.11.2023 | Original Article

Topical Nigella sativa L. product: a new candidate for the management of diabetic peripheral neuropathy

Diabetes is a common and non-communicable disease and is increasing due to the lifestyle and diet habits of people all over the world. This disease causes several long-term complications such as neuropathy, retinopathy, heart and genitourinary …

verfasst von:
Seyed-Ali Khodaie, Haniyeh Nikkhah, Nasim Namiranian, Marzie Abotorabi, Maryam Askari, Saeed Hosein Khalilzadeh, Amidoddin khatibi Aghda, Mohammad kamalinejad