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Inflammation Research OnlineFirst articles

19.02.2021 | Review

Pharmacological mechanism of immunomodulatory agents for the treatment of severe cases of COVID-19 infection

The three recent coronaviruses (CoVs) diseases, including Severe Acute Respiratory Syndrome CoV 1 (SARS-CoV-1), Middle East respiratory syndrome (MERS-CoV), and SARS-CoV-2 (or COVID-19) is associated with the presence of the hyper-inflammatory …

Zahra Bahari, Zohreh Jangravi, Hassan Ghoshooni, Mohammad Reza Afarinesh, Gholam Hossein Meftahi

13.02.2021 | Original Research Paper Open Access

Manifestation of lipopolysaccharide-induced tolerance in neuro-glial primary cultures of the rat afferent somatosensory system

Nociception is the sensory response of an organism to potentially harmful stimuli. It protects the organism from injury and tissue damage [ 1 ]. Peripheral nociceptive nerve endings detect painful stimuli, e.g. strong heat, intense cold, mechanical …

Franz Nürnberger, Stephan Leisengang, Daniela Ott, Jolanta Murgott, Rüdiger Gerstberger, Christoph Rummel, Joachim Roth

12.02.2021 | Original Research Paper

Potential of anthocyanin as an anti-inflammatory agent: a human clinical trial on type 2 diabetic, diabetic at-risk and healthy adults

Metabolic inflammation in type 2 diabetes (T2D), caused by over-nutrition, has given impetus to the further investigation of immuno-metabolism linking inflammation to beta cell (β-cell) dysfunction and insulin resistance [ 1 ]. Excess intake of …

Elham Nikbakht, Indu Singh, Jelena Vider, Lauren T. Williams, Lada Vugic, Almottesembellah Gaiz, Avinash Reddy Kundur, Natalie Colson

10.02.2021 | Original Research Paper

Activated M1 macrophages suppress c-kit expression via TNF-α-mediated upregulation of miR-222 in Neonatal Necrotizing Enterocolitis

Neonatal necrotizing enterocolitis (NEC) is the most common and fatal gastrointestinal emergency in newborns, particularly in premature infants, carrying a mortality rate of 20–50%[ 1 ]. It is thought to be a type of over-reactive intestinal …

Xue Xia, Di Wang, Lei Yu, Bin Wang, Wenjing Wang, Chunlei Jiao, Xuyong Chen, Hongyi Zhang, Feng Chen, Jiexiong Feng

10.02.2021 | Original Research Paper

Therapeutic treatment of dietary docosahexaenoic acid for particle-induced pulmonary inflammation in Balb/c mice

Two important families of polyunsaturated fatty acids (PUFA) are omega-6 and omega-3 which encompass the essential fatty acids of linoleic and α-linolenic acids, respectively. These essential fatty acids are converted into other fatty acids within …

Paige Fletcher, Raymond F. Hamilton Jr., Joseph F. Rhoderick, Britten Postma, Mary Buford, James J. Pestka, Andrij Holian

09.02.2021 | Original Research Paper

Tripterine ameliorates monosodium urate crystal-induced gouty arthritis by altering macrophage polarization via the miR-449a/NLRP3 axis

Gouty arthritis (GA) is an ancient form of inflammatory arthritis that causes hot, red, tender, swollen joints, and is commonly observed in the metatarsal–phalangeal joint [ 1 , 2 ]. GA can develop as a response to the deposition of monosodium …

Yu Wang

09.02.2021 | Review

Notch signaling pathway in infectious diseases: role in the regulation of immune response

The Notch signaling pathway was first described in 1916 through genetic research on Drosophila melanogaster, in which a locus was identified upon the event of mutation, and notches in the wings of the insect were found [ 1 ], hence the name "Notch …

Ricardo Cardoso Castro, Relber Aguiar Gonçales, Fabiana Albani Zambuzi, Fabiani Gai Frantz

29.01.2021 | Review

Tetracycline use in treating osteoarthritis: a systematic review

Idiopathic osteoarthritis is traditionally considered a disease of mechanical cartilage degradation [ 1 ]. Research now characterizes osteoarthritis as a complex disease process involving both mechanical factors and inflammatory contributors [ 2 ].

Brooks N. Platt, Cale A. Jacobs, Caitlin E. W. Conley, Austin V. Stone

28.01.2021 | Original Research Paper

Regulation of Toll-like receptor-mediated inflammatory response by microRNA-152-3p-mediated demethylation of MyD88 in systemic lupus erythematosus

Systemic lupus erythematosus (SLE), a complicated and clinically diverse autoimmune disease, is primarily caused by autoantibodies production and immune complexes deposition, ultimately altering the functions of multiple organs [ 1 ]. The immune …

Bei Tao, Wei Xiang, Xianglong Li, Chengsong He, Ligang Chen, Xiangguo Xia, Tangming Peng, Lilei Peng, Xiaobo Yang, Chuanhong Zhong

27.01.2021 | Original Research Paper

VIP modulates human macrophages phenotype via FPRL1 via activation of RhoA-GTPase and PLC pathways

Macrophages are mononuclear cells that play prominent roles in immune responses. They exhibit their defensive roles mainly through phagocytosis. In addition, they regulate lymphocytes’ activation and proliferation, and they have crucial role in …

Zeina Harhous, Wissam H. Faour, Nabil El Zein

23.01.2021 | Original Research Paper

microRNA-155-3p attenuates intervertebral disc degeneration via inhibition of KDM3A and HIF1α

Intervertebral disc degeneration (IDD) is a long-term, expensive and high-occurrence musculoskeletal disorder, and causes back/neck and radicular-related pain, or even leads to disability [ 1 , 2 ]. IDD is an age-related illness and has high …

Xianwei Zhou, Jitian Li, Junyan Teng, Yufeng Liu, Di Zhang, Linyun Liu, Wenming Zhang

03.12.2019 | Original Research Paper

Acute changes in colonic PGE2 levels as a biomarker of efficacy after treatment of the Pirc (F344/NTac-Apc am1137) rat with celecoxib

Familial adenomatous polyposis (FAP) is a rare inherited disease that results from an autosomal dominant genetic alteration in the adenomatous polyposis coli ( APC ) gene [ 1 ]. Patients with this disease [ 2 ] characteristically develop hundreds …

Changhong Yun, Wan-Mohaiza Dashwood, Li Li, Taijun Yin, Ahmet M. Ulusan, Katherine Shatzer, Song Gao, Ke-He Ruan, Ming Hu

14.11.2019 | Original Research Paper

Genetic association between IL23R rs11209026 and rs10889677 polymorphisms and risk of Crohn’s disease and ulcerative colitis: evidence from 41 studies

Inflammatory bowel disease (IBD) is a complex chronic inflammatory disorder characterized by a chronic illness of unknown etiology [ 1 ]. Crohn’s disease (CD) and ulcerative colitis (UC) are two similar, yet distinct subtypes of IBD [ 2 ]. Both …

Yi Zhu, HongGang Jiang, ZhiHeng Chen, BoHao Lu, Jin Li, XuNing Shen