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Reviews in Endocrine and Metabolic Disorders OnlineFirst articles

22.02.2021 Open Access

Cardiovascular risk and testosterone – from subclinical atherosclerosis to lipoprotein function to heart failure

The cardiovascular (CV) benefit and safety of treating low testosterone conditions is a matter of debate. Although testosterone deficiency has been linked to a rise in major adverse CV events, most of the studies on testosterone replacement …

Baris Gencer, Marco Bonomi, Maria Pia Adorni, Cesare R. Sirtori, François Mach, Massimiliano Ruscica

22.02.2021 | COVID-19 Zur Zeit gratis

Diabetes is most important cause for mortality in COVID-19 hospitalized patients: Systematic review and meta-analysis

The presence of SARS-CoV-2 was officially documented in Europe at the end of February 2020. Despite many observations, the real impact of COVID-19 in the European Union (EU), its underlying factors and their contribution to mortality and morbidity …

Giovanni Corona, Alessandro Pizzocaro, Walter Vena, Giulia Rastrelli, Federico Semeraro, Andrea M Isidori, Rosario Pivonello, Andrea Salonia, Alessandra Sforza, Mario Maggi

18.02.2021 Open Access

Renal complications in patients with chronic hypoparathyroidism on conventional therapy: a systematic literature review

Renal disease in chronic hypoparathyroidism

A systematic literature review was performed to summarize the frequency and nature of renal complications in patients with chronic hypoparathyroidism managed with conventional therapy. Methodology was consistent with the recommendations outlined …

Elvira O. Gosmanova, Pascal Houillier, Lars Rejnmark, Claudio Marelli, John P. Bilezikian

10.02.2021 Open Access

GH deficiency and insensitivity in children and adults

This thematic review includes short reviews on GH deficiency and insensitivity in children and adults from basic science to clinical significance.

Gudmundur Johannsson, John J. Kopchick

05.02.2021 | COVID-19 Zur Zeit gratis

Management of hyponatraemia and hypernatraemia during the Covid-19 pandemic: a consensus statement of the Spanish Society for Endocrinology (Acqua Neuroendocrinology Group)

SARS-COV2 infection has swiftly become a pandemic disease of historic relevance and widely variable outcomes. This variable prognosis is related both to uneven damage, among others, to lungs, heart and kidneys, and to a multisystemic inflammatory …

Alberto Fernandez Martinez, David Barajas Galindo, Jorge Ruiz Sanchez

30.01.2021 Open Access

Paediatric Cushing’s disease: Epidemiology, pathogenesis, clinical management and outcome

Cushing’s disease (CD) is rare in paediatric practice but requires prompt investigation, diagnosis and therapy to prevent long-term complications. Key presenting features are a change in facial appearance, weight gain, growth failure …

Rosario Ferrigno, Valeria Hasenmajer, Silvana Caiulo, Marianna Minnetti, Paola Mazzotta, Helen L Storr, Andrea M Isidori, Ashley B Grossman, Maria Cristina De Martino, Martin O Savage

16.01.2021 Open Access

Effects of offloading devices on static and dynamic balance in patients with diabetic peripheral neuropathy: A systematic review

Patients with diabetic peripheral neuropathy (DPN) usually have reduced somatosensory information and altered perception in feet and ankles. Somatosensory information acts as feedback for movement control and loss of somatosensation leads to …

Koen Andre Horstink, Lucas Henricus Vincentius van der Woude, Juha Markus Hijmans


Update in carcinoid heart disease - the heart of the matter

Carcinoid heart disease (CHD) is a paraneoplastic cardiac manifestation occurring in patients with carcinoid syndrome (CS) and advanced neuroendocrine malignancy. In about 20–40% of patients with CS, chronic exposure to tumor-released circulating …

Kira Oleinikov, Amit Korach, David Planer, Dan Gilon, Simona Grozinsky-Glasberg


Intercellular and interorgan crosstalk through adipocyte extracellular vesicles

Functional adipose tissue is essential for homeostatic maintenance of systemic metabolism. As such, adipose tissue dysfunction, like that seen in the obese state, directly contributes to system-wide pathological metabolism, leading to the …

Clair Crewe, Philipp E. Scherer


Diabetes mellitus induced by immune checkpoint inhibitors: type 1 diabetes variant or new clinical entity? Review of the literature

Immune Check-Point Inhibitors (CPIs) have improved long-term patients’ outcomes in several advanced cancers. Diabetes mellitus induced by CPIs (CPI-DM) is considered the second most frequent endocrine CPIs’ side effects with a variable prevalence …

V. Lo Preiato, S. Salvagni, C. Ricci, A. Ardizzoni, U. Pagotto, C. Pelusi

06.01.2021 | Correction

Correction to: Endocrine and metabolic aspects of the COVID-19 pandemic

A Correction to this paper has been published: …

Mónica Marazuela, Andrea Giustina, Manuel Puig-Domingo


Lean NAFLD: an underrecognized and challenging disorder in medicine

Classically, Non-Alcoholic Fatty Liver Disease (NAFLD) has been thought to be driven by excessive weight gain and obesity. The overall greater awareness of this disorder has led to its recognition in patients with normal body mass index (BMI).

Sheila Maier, Amanda Wieland, Melanie Cree-Green, Kristen Nadeau, Shelby Sullivan, Miguel A. Lanaspa, Richard J. Johnson, Thomas Jensen


The endocannabinoid system in the adipose organ

The endocannabinoid system is found in most, if not all, mammalian organs and is involved in a variety of physiological functions, ranging from the control of synaptic plasticity in the brain to the modulation of smooth muscle motility in the …

Kwang-Mook Jung, Lin Lin, Daniele Piomelli


Polyphenols and their anti-obesity role mediated by the gut microbiota: a comprehensive review

Obesity is a global public health problem that results in chronic pathologies such as diabetes, cardiovascular diseases, and cancer. The treatment approach based on energy restriction and promotion of physical activity is ineffective in the long …

Lissette Duarte, Naschla Gasaly, Carlos Poblete-Aro, Denisse Uribe, Francisca Echeverria, Martin Gotteland, Diego F Garcia-Diaz

02.12.2020 Open Access

How the love of muscle can break a heart: Impact of anabolic androgenic steroids on skeletal muscle hypertrophy, metabolic and cardiovascular health

It is estimated 6.4% of males and 1.6% of females globally use anabolic-androgenic steroids (AAS), mostly for appearance and performance enhancing reasons. In combination with resistance exercise, AAS use increases muscle protein synthesis …

Deaglan McCullough, Richard Webb, Kevin J. Enright, Katie E. Lane, Jim McVeigh, Claire E. Stewart, Ian G. Davies


Modelling gestational diabetes mellitus: large animals hold great promise

Gestational diabetes mellitus (GDM) characterized by hyperglycemia during pregnancy is a risk factor for various maternal and fetal complications. The key pathophysiological mechanisms underlying its development have not been elucidated, largely …

Xiang Gao, Junsheng He, Anming Zhu, Kang Xie, Kaixuan Yan, Xue Jiang, Ying Xu, Qin Li, Aimin Xu, Dewei Ye, Jiao Guo

25.11.2020 | COVID-19 Open Access

COVID-19 und die Schilddrüse – ein Fall von wechselseitiger Beeinflussung?

Zwischen Schilddrüse und Virusinfektionen entspinnt sich über Hormone und immunmodulatorische Signalmoleküle ein komplexes Zusammenspiel. Welche Bedeutung hat das bei COVID-19? Lesen Sie hier eine englischsprachige Arbeit, in der ein internationales Team die aktuellen Erkenntnisse zusammenfasst.

Lorenzo Scappaticcio, Fabián Pitoia, Katherine Esposito, Arnoldo Piccardo, Pierpaolo Trimboli


Skeletal abnormalities in Hypoparathyroidism and in Primary Hyperparathyroidism

Both hypoparathyroidism (HypoPT), as well as its pathological counterpart, primary hyperparathyroidism (PHPT), can lead to skeletal abnormalities. Chronic deficiency of PTH in patients with HypoPT is associated with a profound reduction in bone …

Barbara C. Silva, John P. Bilezikian


The experiences of pregnant women with gestational diabetes mellitus: a systematic review of qualitative evidence

Gestational diabetes mellitus (GDM) can have serious adverse effects on pregnant women and their fetuses. The purpose of this systematic review is to explore responses from women diagnosed with GDM and to describe their real-life experiences with …

Jing He, Xiaoli Chen, Yuchen Wang, Yanqun Liu, Jinbing Bai

09.11.2020 Open Access

Classification of neuroendocrine neoplasms: lights and shadows

Neuroendocrine neoplasms (NENs) are a heterogeneous group of neoplastic proliferations showing different morphological features, immunophenotype, molecular background, clinical presentation, and outcome. They can virtually originate in every organ …

Stefano La Rosa, Silvia Uccella