Journal of Natural Medicines OnlineFirst articles

09.04.2024 | Note

New biflavonoids isolated from Xylia kerrii leaves extract with selective cytotoxicity against MH7A human rheumatoid arthritis synovial fibroblast cells

Three new biflavonoids (1–3) and two known flavonoids (4, 5) were isolated from Xylia kerrii collected in Thailand. Compounds 1–5 showed selective cytotoxicity against the rheumatoid fibroblast-like synovial MH7A cell line, and these compounds …

verfasst von:: Kazuki Fujii, Itsuki Iwata, Akiko Takaya, Masami Ishibashi, Yasumasa Hara

08.04.2024 | Note

Hypoglycemic effects of mountain caviar extract and inhibitory mechanism of saponins, including momordin Ic, on glucose absorption

Mountain caviar is a fruit of Kochia scoparia that contains momordin Ic as a major saponin constituent. Its extract (MCE) has been shown to suppress blood glucose elevations in the human oral glucose tolerance test (OGTT) as well as increases in …

verfasst von:: Kenchi Miyasaka, Ryuya Takada, Jianbo Wu, Shogo Takeda, Yoshiaki Manse, Toshio Morikawa, Hiroshi Shimoda

08.04.2024 | Original Paper

Proposal for structure revision of pinofuranoxin A through total syntheses of stereoisomers

The relative configuration of the epoxide functionality in pinofuranoxin A (1), α-alkylidene-β-hydroxy-γ-methyl-γ-butyrolactone with trans-epoxy side chain isolated by Evidente et al. in 2021, was revised by DFT-based spectral reinvestigations and …

verfasst von:: Kazuki Ujiie, Chiaki Tanaka, Masayoshi Arai, Masaru Hashimoto, Yuki Yoshida, Tomikazu Kawano, Satoru Tamura

04.04.2024 | Note

Alkylphthalides with intracellular triglyceride metabolism-promoting activity from the rhizomes of Cnidium officinale Makino

Methanol extract of the Cnidium officinale Makino rhizome, which is used as a crude drug Cnidium Rhizome (Cnidii Rhizoma; “Senkyu” in Japanese) and is listed in the Japanese Pharmacopoeia XVIII, showed intracellular triglyceride …

verfasst von:: Toshio Morikawa, Naoki Inoue, Saya Yamamoto, Miyuki Shiotani, Yoshiaki Manse, Kiyofumi Ninomiya

04.04.2024 | Original Paper

Compound–compound interaction analysis of baicalin and berberine derivatives in aqueous solution

Baicalin and berberine are biologically active constituents of the crude drugs Scutellaria root and Coptis rhizome/Phellodendron bark, respectively. Baicalin and berberine are reported to combine together as a 1:1 complex that forms yellow …

verfasst von:: Yoshinori Uekusa, Chiharu Tanioka, Kenjiro Nakamoto, Riina Tsutsumi, Chihiro Iida, Naoto Enshu, Takehiro Nishimura, Fumiyuki Kiuchi, Haruhisa Kikuchi

04.04.2024 | Note

Cryptobuchanosides A–G: seven previously undescribed triterpene glycosides from Cryptolepis buchananii R.Br. ex Roem. and Schult. with nitric oxide production inhibition activity

In this study, nine triterpene glycosides including seven previously undescribed compounds (1–7), were isolated from leaves of Cryptolepis buchananii R.Br. ex Roem. and Schult. using various chromatographic methods. The chemical structures of the …

verfasst von:: Ngo Anh Bang, Nguyen Duc Duy, Bui Huu Tai, Nguyen Thi Kim Thuy, Pham Hai Yen, Duong Thi Dung, Nguyen Huy Hoang, Nguyen Xuan Nhiem, Ninh Khac Ban, Phan Van Kiem

Open Access 03.04.2024 | Correction

Correction: Evaluation of rooting characteristics of Ephedra cuttings by anatomy and promising strain selection based on rooting characteristics and alkaloid content

verfasst von:: Yoshitomi Kudo, Hirokazu Ando, Ai Kaneda, Honoka Ito, Kazuki Umemoto, Si-ran Ni, Masayuki Mikage, Yohei Sasaki

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Open Access 03.04.2024 | Correction

Correction: Heating or ginger extract reduces the content of Pinellia ternata lectin in the raphides of Pinellia tuber

verfasst von:: Yan Liu, Itsuki Nose, Kazuyoshi Terasaka, Tsukasa Fueki, Toshiaki Makino

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02.04.2024 | Rapid Communication

Vincarostine A, a novel anti-malarial trimeric monoterpenoid indole alkaloid from Catharanthus roseus

A novel trimeric monoterpenoid indole alkaloid, vincarostine A (1) consisting of an aspidosperma-iboga-aspidosperma type skeleton, was isolated from the whole plant of Catharanthus roseus. The structure including absolute stereochemistry was …

verfasst von:: Yusuke Hirasawa, Yusuke Kakizoe, Takahiro Tougan, Nahoko Uchiyama, Toshihiro Horii, Hiroshi Morita

02.04.2024 | Original Paper

Oxomollugin, an oxidized substance in mollugin, inhibited LPS-induced NF-κB activation via the suppressive effects on essential activation factors of TLR4 signaling

Oxomollugin is a degraded product of mollugin and was found to be an active compound that inhibits LPS-induced NF-κB activation. In this study, we investigated the inhibitory activity of oxomollugin, focusing on TLR4 signaling pathway, resulting …

verfasst von:: Yuki Nakajima, Naohide Tsuboi, Kumiko Katori, Maigunuer Waili, Alfarius Eko Nugroho, Kazunori Takahashi, Hitomi Nishino, Yusuke Hirasawa, Yoko Kawasaki, Yukihiro Goda, Toshio Kaneda, Hiroshi Morita

Open Access 02.04.2024 | Correction

Correction: Preparation and pharmaceutical properties of Hangeshashinto oral ointment and its safety and efficacy in Syrian hamsters with 5-fluorouracil-induced oral mucositis

verfasst von:: Takashi Ogihara, Masato Kagawa, Rintarou Yamanaka, Satoshi Imai, Kotaro Itohara, Daiki Hira, Shunsaku Nakagawa, Atsushi Yonezawa, Michiho Ito, Takayuki Nakagawa, Tomohiro Terada, Kazuo Matsubara

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26.03.2024 | Original Paper

Bajitianwan formula extract ameliorates bone loss induced by iron overload via activating RAGE/PI3K/AKT pathway based on network pharmacology and transcriptomic analysis

Osteoporosis (OP) is closely related to iron overload. Bajitianwan (BJTW) is a traditional Chinese medicine formulation used for treating senile diseases such as dementia and osteoporosis. Modern pharmacological researches have found that BJTW has …

verfasst von:: Weifan Xu, Tao Jiang, Luying Ding, Yiping Jiang, Lichao Zhang, Tianshuang Xia, Hailiang Xin

22.03.2024 | Original Paper

A new 3,4-seco-isopimarane and three new isopimarane diterpenoids from Kaempferia champasakensis collected from Vietnam and their cytotoxic activities

A phytochemical investigation of Kaempferia champasakensis rhizomes led to the isolation of a new 3,4-seco-isopimarane diterpene, kaempferiol A (1), and three new isopimarane diterpenes, kaempferiols B–D (2–4), together with six known isopimarane …

verfasst von:: Kiep Minh Do, Shotaro Hoshino, Takeshi Kodama, Hien Minh Nguyen, Son Van Le, Naotaka Ikumi, Hiroyasu Onaka, Hiroyuki Morita

Open Access 22.03.2024 | Mini-Review

Non-enzymatic reactions in biogenesis of fungal natural products

Fungi have long been regarded as abundant sources of natural products (NPs) exhibiting significant biological activities. Decades of studies on the biosynthesis of fungal NPs revealed that most of the biosynthetic steps are catalyzed by …

verfasst von:: Shinji Kishimoto

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22.03.2024 | Original Paper

Alliaxylines A–E: five new mexicanolides from the stem barks of Dysoxylum alliaceum (Blume) Blume ex A.Juss

A total of five new mexicanolides (1–5), namely alliaxylines A–E, together with two known limonoids 6 and 7, were isolated and identified from Dysoxylum alliaceum (Blume) Blume ex. A.Juss. (Meliaceae). The structures of these compounds were …

verfasst von:: Sandra Amalia Riyadi, Al Arofatus Naini, Tri Mayanti, Ronny Lesmana, Mohamad Nurul Azmi, Sofa Fajriah, Siriporn Jungsuttiwong, Unang Supratman

21.03.2024 | Natural Resource Letter

Inhibitory effects of senkyuchachosan on SARS-CoV-2 papain-like protease activity in vitro

COVID-19, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has emerged as one of the most significant global pandemics in recent years [ 1 ]. According to the World Health Organization, SARS-CoV-2 has infected over 760 …

verfasst von:: Yuka Kiba, Takashi Tanikawa, Tsuyoshi Hayashi, Takami Yokogawa, Aiko Sano, Ryuichiro Suzuki, Masashi Kitamura

21.03.2024 | Original Paper

Photoreaction products of extract from the fruiting bodies of Polyozellus multiplex

Photochemical reactions are powerful tools for synthesizing organic molecules. The input of energy provided by light offers a means to produce strained and unique molecules that cannot be assembled using thermal protocols, allowing for the …

verfasst von:: Hayato Otsuka, Keiyo Nakai, Emi Shimizu, Takamasa Yamaguchi, Mitsuhisa Yamano, Hiroaki Sasaki, Kiyotaka Koyama, Kaoru Kinoshita

21.03.2024 | Mini-Review

Recent trends in ginseng research

Ginseng, the dried root of Panax ginseng, contains ginsenosides and has long been used in Korea, China, and Japan to treat various symptoms. Many studies on the utility of ginseng have been conducted and in this paper we investigate recent trends …

verfasst von:: Honoka Ito, Michiho Ito

19.03.2024 | Natural Resource Letter

Resultant compound from sublimation test for Gentianae Radix in Japanese Pharmacopoeia was 5-(hydroxymethyl)furfural

Gentianae Radix, an herbal medicine, has been used as a gastrointestinal drug in Japan. In the Japanese Pharmacopoeia 18th Revision, the sublimation test is specified as an identification test for Gentianae Radix. The compound obtained in this …

verfasst von:: Atsushi Tsuge, Yuto Goto, Sayaka Masada, Michiho Ito

Open Access 18.03.2024 | Original Paper

The protective effects of Ninjin’yoeito against liver steatosis/fibrosis in a non-alcoholic steatohepatitis model mouse

Non-alcoholic steatohepatitis (NASH) is a progressive fibrotic form of non-alcoholic fatty liver disease. Liver fibrosis leads to liver cancer and cirrhosis, and drug therapy for NASH remains lacking. Ninjin’yoeito (NYT) has shown antifibrotic …

verfasst von:: Kyohei Takano, Marisa Kaneda, Yayoi Aoki, Nina Fujita, Shigeki Chiba, Seiwa Michihara, Li-Kun Han, Ryuji Takahashi

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Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

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