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Forensic Toxicology OnlineFirst articles

10.08.2022 | Short Communication

Analysis of vaporized caffeine in smoke from e-cigarettes using liquid chromatography–tandem mass spectrometry and clarification of minor components

Electronic cigarettes (e-cigarettes) and heat-not-burn tobaccos have attracted considerable attention recently as alternatives to smoking tobacco and are marketed globally by tobacco companies. However, research has raised issues about their risk …

verfasst von:
Makoto Takada, Suzuna Saruwatari, Yutaro Yanagita, Junpei Mutoh, Hajime Harada, Naoya Kishikawa, Takashi Kitahara, Naotaka Kuroda, Mitsuhiro Wada

Open Access 06.08.2022 | Original Article

Influence of long-term storage temperatures and sodium fluoride preservation on the stability of synthetic cathinones and dihydro-metabolites in human whole blood

Synthetic cathinones (SCt), a class of new psychoactive substances (NPS), are structurally derived from cathinone, which is the principal psychoactive component of the “Khat” plant ( Catha edulis ) [ 1 ]. These drugs, also known as “legal highs’ …

verfasst von:
Abdulaziz A. Aldubayyan, Erika Castrignanò, Simon Elliott, Vincenzo Abbate

03.08.2022 | Letter to the Editor

Blood transfusion causing false positive PEth

verfasst von:
Brian Lewis, Daniel Brooks

06.07.2022 | Original Article

Analysis of degradation products of nerve agents in biological fluids by ion chromatography–tandem mass spectrometry

Nerve agents such as sarin and VX are highly toxic organophosphorus compounds that inhibit the activity of cholinesterase [ 1 ]. Their production, storage, and use are strictly controlled by national and international law [ 2 ]. Nevertheless, these …

verfasst von:
Mai Otsuka, Hajime Miyaguchi

28.06.2022 | Original Article

The next addiction-causing drug class 4-quinazolinone derivatives: analyses of methaqualone analogs including recently discovered 2-methoxyqualone by different modes of mass spectrometry

The sedative-hypnotic activity of methaqualone (structure see Fig. 1 a), a 4-quinazolinone derivative, was first noted in 1955 in Europe. In 1962, methaqualone was patented in the U.S.A. by Wallace and Tiernan [ 1 ]. It was peaked in early 1970s …

verfasst von:
Hongkun Yang, Yue Wang, Jinlei Liu, Shi Qiu, Jie Gu, Huiru Bai, Jun Li, Amin Wurita, Koutaro Hasegawa

Open Access 28.06.2022 | Case Report

Simultaneous fatal poisoning of two victims with 4F-MDMB-BINACA and ethanol

Synthetic cannabinoid receptor agonists (SCRAs) gained popularity in the late 2000s [ 1 ]. The limited information to date regarding their pharmacology and toxicology and the increasing diversity in their structures raises public health concerns [ …

verfasst von:
Gábor Simon, Dénes Tóth, Veronika Heckmann, Mátyás Mayer, Mónika Kuzma

04.06.2022 | Original Article

Methyl (S)-2-(1–7 (5-fluoropentyl)-1H-indole-3-carboxamido)-3,3-dimethylbutanoate (5F-MDMB-PICA) intoxication in a child with identification of two new metabolites (ultra-high-performance liquid chromatography–tandem mass spectrometry)

Synthetic cannabinoids (SCs) are one of groups of compounds that have an ability to bind to cannabinoid receptors. Aside from them, there are ligands such as endocannabinoids (e.g., anandamide) and natural compounds that are produced by plants …

verfasst von:
Paweł Szpot, Karolina Nowak, Olga Wachełko, Kaja Tusiewicz, Agnieszka Chłopaś-Konowałek, Marcin Zawadzki

06.12.2019 | Case Report

A fatal case report of acute yohimbine intoxication

Yohimbine is an indole alkaloid extracted from the bark of the Pausinystalia yohimbe tree, which mainly grows in West Africa [ 1 ]. Yohimbine acts as an adrenoceptor blocking agent acting selectively on α 2-receptors [ 1 ]. Yohimbine has a low and …

verfasst von:
Guillaume Drevin, Maeva Palayer, Patricia Compagnon, Donca Zabet, Nathalie Jousset, Marie Briet, Chadi Abbara

02.12.2019 | Original Article

Identification and imaging of indole-3-carboxamide cannabinoids in hair using matrix-assisted laser-desorption/ionization mass spectrometry

Segmental hair analysis provides an alternative tool in additive drug monitoring and forensic analysis. Compared with drug analysis in biological fluids including blood or urine, hair sample analysis can provide a prolonged detection window …

verfasst von:
Houwei Lin, Xiaoyan Zeng, Qian Wang, Yinnan Li, Bin Sun, Ying Wang, Hang Wang

Open Access 17.11.2019 | Short Communication

Development and application of a forensic toxicological library for identification of 56 natural toxic substances by liquid chromatography–quadrupole time-of-flight mass spectrometry

Natural toxins are chemicals that are naturally produced by living organisms such as some plants, mushrooms, marine animals, and so on [ 1 ]. These toxins are not harmful to the organisms themselves but they may be toxic to other creatures …

verfasst von:
Tadashi Ogawa, Kei Zaitsu, Tetsuo Kokaji, Kayako Suga, Fumio Kondo, Masae Iwai, Takayoshi Suzuki, Akira Ishii, Hiroshi Seno

15.10.2019 | Original Article

Targeting the administration of ecdysterone in doping control samples

Ecdysterone (chemical structure in Fig. 1 ) is widely marketed as a “natural anabolic agent”, advertised to increase strength and muscle mass during resistance training to reduce fatigue and to ease recovery. Growth promoting and anabolic effects …

verfasst von:
Maria Kristina Parr, Gabriella Ambrosio, Bernhard Wuest, Monica Mazzarino, Xavier de la Torre, Francesca Sibilia, Jan Felix Joseph, Patrick Diel, Francesco Botrè

Open Access 30.09.2019 | Case Report

Identification of the designer benzodiazepine 8-chloro-6-(2-fluorophenyl)-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine (flualprazolam) in an anesthesia robbery case

In recent years, a large number of new psychoactive substances (NPS) have emerged on the drugs market, with 899 substances being reported to the United Nations Office on Drugs and Crime (UNODC) in 2019 [ 1 ]. Many different classes of NPS, such as …

verfasst von:
Zhenhua Qian, Cuimei Liu, Jian Huang, Qingqing Deng, Zhendong Hua

24.08.2019 | Original Article

Determination of drug distributions in decomposed and buried postmortem tissues and bones of pigs administered of drugs

Postmortem toxicological analyses may provide significant information in determining the cause of death or in explanation of forensic cases. Traditionally, body fluids such as blood and urine are investigated in cases of intoxication and …

verfasst von:
Ismail Ethem Goren, Nebile Gokce Daglioglu, Yusuf Kenan Daglioglu, Mete Korkut Gülmen

31.07.2019 | Case Report

Attempt of scopolamine-facilitated robbery: an original case of poisoning by inhalation confirmed by LC–MS/MS and review of the literature

The use of scopolamine, an alkaloid found in certain plants, has been reported to be used to incapacitate people for criminal gain. Preparations containing scopolamine are known in South America as Burundanga and in Asia as Devil’s breath, and are …

verfasst von:
Laurène Dufayet, Elizabeth Alcaraz, Jack Dorol, Caroline Rey-Salmon, Jean-Claude Alvarez

03.07.2019 | Original Article

Metabolism of the benzodiazepines norflurazepam, flurazepam, fludiazepam and cinolazepam by human hepatocytes using high-resolution mass spectrometry and distinguishing their intake in authentic urine samples

Benzodiazepines are central nervous system depressants that have been prescribed for their anticonvulsant, anxiolytic, sedative or hypnotic effects since the 1960s [ 1 ]. They induce the effects by acting on the gamma-aminobutyric acid A (GABA A ) …

verfasst von:
Shimpei Watanabe, Svante Vikingsson, Anna Åstrand, Volker Auwärter, Henrik Gréen, Robert Kronstrand

17.06.2019 | Case Report

Case report on two-cathinones abuse: MPHP and N-ethyl-4′methylnorpentedrone, with a fatal outcome

New psychoactive drugs (NPS) are increasingly being identified in cases of drugs abuse. It is a major public health problem in the world. Logan et al. reviewed NPS use in the USA between 2013 and 2016, which included: synthetic cannabinoids, new …

verfasst von:
Lelievre Benedicte, Richeval Camille, Coulon Audrey, Iwanikow Deborah, Brofferio Morgan, Deguigne Marie, Boels David, Allorge Delphine, Ferec Severine, Drevin Guillaume, Jousset Nathalie, Gaulier Jean-Michel

Open Access 04.06.2019 | Case Report

Fatal intoxication with N-ethylpentylone: a case report and method for determining N-ethylpentylone in biological material

N -Ethylpentylone (IUPAC name: 1-(2H-1,3-benzodioxol-5-yl)-2-(ethylamino)pentan-1-one) belongs to the group of synthetic cathinones, which in recent years have gained popularity on the illegal drug market. The increased interest in N …

verfasst von:
Marcin Zawadzki, Karolina Nowak, Paweł Szpot