Delirium, the most common hospital-acquired complication worldwide, is characterized by shifting attention, incoherence, disorientation, and impaired cognition. 1 It is a frightening experience for the person affected, and their sudden change in …
Dihydropyridine calcium channel blockers (DCCBs), such as amlodipine and nifedipine, are first-line antihypertensive agents alongside thiazide diuretics, angiotensin-converting enzyme (ACE) inhibitors, and angiotensin receptor blockers (ARB). 1 …
verfasst von:
Matthew F. Blum, MD, MHS, Aditya Surapaneni, PhD, Alexander Chang, MD, MSc, Lesley A. Inker, MD, MS, Teresa K. Chen, MD, MHS, Lawrence J. Appel, MD, MPH, Jung-Im Shin, MD, PhD, Morgan E. Grams, MD, PhD
Pragmatism in clinical trials is focused on increasing the generalizability of research findings for routine clinical care settings. Hybridism in clinical trials (i.e., assessing both clinical effectiveness and implementation success) is focused …
verfasst von:
John C. Fortney, PhD, Geoffrey M. Curran, PhD, Aaron R. Lyon, PhD, Devon K. Check, PhD, David R. Flum, MD
Depression is a leading cause of disability and disease burden in the United States (U.S.) with a lifetime prevalence of up to 21% and widespread impact on social and emotional functioning. 1 Past research has demonstrated medical conditions …
verfasst von:
Jason I. Chen, PhD, David Bui, PhD, Theodore J. Iwashyna, MD, PhD, Troy A. Shahoumian, MPH, PhD, Alex Hickok, MS, Megan Shepherd-Banigan, PhD, Eric J. Hawkins, PhD, Jennifer Naylor, PhD, Diana J. Govier, MPH, PhD, Thomas F. Osborne, MD, Valerie A. Smith, DrPh, C. Barrett Bowling, MD, MSPH, Edward J. Boyko, MD, MPH, George N. Ioannou, BMBCh, MS, Matthew L. Maciejewski, PhD, Ann M. O’Hare, MA, MD, Elizabeth M. Viglianti, MD, MPH, Amy S.-B. Bohnert, PhD, Denise M. Hynes, MPH, PhD, RN, for the V. A. HSRDSARS-C.O.V.-2 Observational Research Collaboratory (CORC)
The COVID-19 pandemic disrupted patients’ usual patterns of receiving in-person primary care services. The Veterans Health Administration (VHA) rapidly mobilized synchronous telemedicine (real-time video or telephone visits) in primary care. 1 Like …
verfasst von:
Jonathan Staloff, MD, MSc, Eric Gunnink, MS, Jorge Rojas Jr., MS, Edwin S. Wong, PhD, Karin Nelson, MD, MSHS, Ashok Reddy, MD, MSc
Cough is the most common illness-related reason for an ambulatory care visit, accounting for 2.7 million outpatient visits and more than 4 million emergency department visits annually. 1 Cough is a symptom; acute bronchitis is inflammation of …
verfasst von:
Daniel J. Merenstein, MD, Bruce Barrett, MD, PhD, Mark H. Ebell, MS, MD
The integration of ultrasound into medical education has not yet been adequately addressed. There is no international consensus on how ultrasound teaching should be incorporated into the traditional curriculum or the way skills testing should be …
verfasst von:
E. Höhne, MD, F. Recker, MD, PhD, MME, P. Brossart, MD, PhD, V. S. Schäfer, MD, PhD
Over the past 40 years, sociological and epidemiological studies have shown that self-rated health is an independent predictor of mortality. 1 , 2 Self-rated health is a global summary obtained by asking an individual to categorize their own health …
verfasst von:
Scott Z. Mu, MD, MHS, Caitlin W. Hicks, MD, MS, Natalie R. Daya, MPH, Randi E. Foraker, PhD, MA, Anna M. Kucharska-Newton, PhD, MPH, Pamela L. Lutsey, PhD, MPH, Josef Coresh, MD, PhD, Elizabeth Selvin, PhD, MPH
Nirmatrelvir-ritonavir received emergency use authorization by the U.S. Food and Drug Administration in December 2021 to treat ambulatory patients diagnosed with COVID-19 at risk of developing severe disease. 1 Ritonavir is an inhibitor of hepatic …
verfasst von:
Nicholas Spetko, MD, Brianna X. Wang, BS, Shoshana J. Herzig, MD, MPH, Timothy S. Anderson, MD, MAS
Economists describe three types of unemployment: frictional unemployment, structural unemployment, and demand-deficient unemployment. Frictional unemployment stems from the job search that matches employers and employees. When searching, people are …
Heart failure (HF) poses a substantial economic burden worldwide, 1 , 2 a large part attributed to inpatient costs resulting from multiple readmissions. 3 HF is among the leading causes of 30-day readmissions, 4 a substantial portion of which are …
verfasst von:
Ishwarya Balasubramanian, PhD, Chetna Malhotra, MD, on behalf of the SCOPAH study group
The patient-physician relationship, especially in the case of severely ill patients, is often fraught with anxiety, grief, and guilt in the physician who may come to feel that he or she has failed the patient and thereby becomes a “second victim.” …
verfasst von:
Catherine Pressimone, MD, Renusha Indralingam, BS, Cameron Dowiak Metz, BS, Arthur S. Levine, MD
Multiple case reports have suggested a potential association between sodium glucose co-transporter 2 inhibitors (SGLT2i) and elevated hemoglobin (hgb) levels. 1 , 2 Our objective was to evaluate the change in hgb among patients with type 2 diabetes …
verfasst von:
Mats C. Højbjerg Lassen, MD, Michael Colacci, MD, Manan Pareek, MD, PhD, FAHA, Stephanie G. Lee, MD, MSc, Gunnar Gislason, MD, PhD, Michael Fralick, MD, PhD, SM, Tor Biering-Sørensen, MD, MSc, MPH, PhD
Frailty is a clinical state of reduced physiologic reserve and increased vulnerability to poor health outcomes. The prevalence of frailty is 12 to 24% in community-dwelling older adults 1 and almost 50% in hospitalized patients 2 and nursing home …
verfasst von:
Aaron Yao, PhD, Linhui Gao, MS, Jiajun Zhang, MS, Joyce M. Cheng, BA, Dae Hyun Kim, MD, ScD
Overdoses and mortality associated with opioids continue to be a public health crisis in the USA 1 , 2 , especially for patients in the Veterans Health Administration (VA) health care system 3 , 4 . Opioid overdose mortality rates rose over 50% …
verfasst von:
Alicia A. Bergman, PhD, Rebecca S. Oberman, MPH, MSW, Stephanie L. Taylor, PhD, Bridget Kranke, MSSA, LSW, Evelyn T. Chang, MD, MSHS
Patients with diabetes have higher hospitalization rates compared to those without diabetes due to diabetes related complications including ischemic heart disease, heart failure, renal failure, neuropathy, and infections. 1 , 2 Studies have shown …
verfasst von:
Yuting Ye, M.D., Bernardo A. Acevedo-Mendez, M.D., Stephanie Izard, M.P.H, Alyson K. Myers, M.D.
The use of chronological age as a central metric for prognosticating outcomes in older adults presents limitations, yet older age is considered a risk factor for poor COVID-19 prognosis. 1 , 2 In line with the concept of immunosenescence, aging can …
verfasst von:
Valerie Danesh, PhD RN, Alaina Tellson, PhD RN, Leanne M. Boehm, PhD RN ACNS-BC, Alan B. Stevens, PhD, Gerald O. Ogola, PhD, Anisha Shrestha, MS, Jinmyoung Cho, PhD, Edgar J. Jimenez, MD, Alejandro C. Arroliga, MD MSc
