Frontiers of Medicine OnlineFirst articles

15.04.2024 | Review

Pathological progression of osteoarthritis: a perspective on subchondral bone

Osteoarthritis (OA) is a degenerative bone disease associated with aging. The rising global aging population has led to a surge in OA cases, thereby imposing a significant socioeconomic burden. Researchers have been keenly investigating the …

verfasst von:: Xuefei Li, Wenhua Chen, Dan Liu, Pinghua Chen, Shiyun Wang, Fangfang Li, Qian Chen, Shunyi Lv, Fangyu Li, Chen Chen, Suxia Guo, Weina Yuan, Pan Li, Zhijun Hu

11.04.2024 | Review

Cancer stem cell-immune cell crosstalk in the tumor microenvironment for liver cancer progression

Crosstalk between cancer cells and the immune microenvironment is determinant for liver cancer progression. A tumor subpopulation called liver cancer stem cells (CSCs) significantly accounts for the initiation, metastasis, therapeutic resistance …

verfasst von:: Yue Ma, Hongwei Lv, Fuxue Xing, Wei Xiang, Zixin Wu, Qiyu Feng, Hongyang Wang, Wen Yang

02.04.2024 | Review

Trajectory of COVID-19 response and management strategy in China: scientific rationale driven strategy adjustments

The pneumonia caused by novel coronavirus SARS-CoV-2 infection in early December 2019, which was later named coronavirus disease 2019 (COVID-19) by the World Health Organization (WHO), rapidly spread across the world. China has made extraordinary …

verfasst von:: Zeyu Zhang, Yue Yan, Lina Zhao, Yizhou Bian, Ning Zhao, You Wu, Dahai Zhao, Zongjiu Zhang

02.04.2024 | Review

Emergence of SARS and COVID-19 and preparedness for the next emerging disease X

Severe acute respiratory syndrome (SARS) and Coronavirus disease 2019 (COVID-19) are two human Coronavirus diseases emerging in this century, posing tremendous threats to public health and causing great loss to lives and economy. In this review …

verfasst von:: Ben Hu, Hua Guo, Haorui Si, Zhengli Shi

16.03.2024 | Research Article

A distinct “repair” role of regulatory T cells in fracture healing

Regulatory T cells (Tregs) suppress immune responses and inflammation. Here, we described the distinct nonimmunological role of Tregs in fracture healing. The recruitment from the circulation pool, peripheral induction, and local expansion rapidly …

verfasst von:: Tingting Wu, Lulu Wang, Chen Jian, Zhenhe Zhang, Ruiyin Zeng, Bobin Mi, Guohui Liu, Yu Zhang, Chen Shi

16.03.2024 | Research Article

Dysregulated N6-methyladenosine modification in peripheral immune cells contributes to the pathogenesis of amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis (ALS) is a progressive neurogenerative disorder with uncertain origins. Emerging evidence implicates N6-methyladenosine (m6A) modification in ALS pathogenesis. Methylated RNA immunoprecipitation sequencing (MeRIP-seq) …

verfasst von:: Di He, Xunzhe Yang, Liyang Liu, Dongchao Shen, Qing Liu, Mingsheng Liu, Xue Zhang, Liying Cui

11.03.2024 | Research Article

Arginine methylation of ALKBH5 by PRMT6 promotes breast tumorigenesis via LDHA-mediated glycolysis

ALKBH5 is a master regulator of N6-methyladenosine (m6A) modification, which plays a crucial role in many biological processes. Here, we show that ALKBH5 is required for breast tumor growth. Interestingly, PRMT6 directly methylates ALKBH5 at R283 …

verfasst von:: Xue Han, Chune Ren, Aifang Jiang, Yonghong Sun, Jiayi Lu, Xi Ling, Chao Lu, Zhenhai Yu

08.03.2024 | Review

Immune landscape and response to oncolytic virus-based immunotherapy

Oncolytic virus (OV)-based immunotherapy has emerged as a promising strategy for cancer treatment, offering a unique potential to selectively target malignant cells while sparing normal tissues. However, the immunosuppressive nature of tumor …

verfasst von:: Chaolong Lin, Wenzhong Teng, Yang Tian, Shaopeng Li, Ningshao Xia, Chenghao Huang

Open Access 01.03.2024 | Review

Gut microbiota-dependent phenylacetylglutamine in cardiovascular disease: current knowledge and new insights

Phenylacetylglutamine (PAGln) is an amino acid derivate that comes from the amino acid phenylalanine. There are increasing studies showing that the level of PAGln is associated with the risk of different cardiovascular diseases. In this review, we …

verfasst von:: Yaonan Song, Haoran Wei, Zhitong Zhou, Huiqing Wang, Weijian Hang, Junfang Wu, Dao Wen Wang

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08.02.2024 | Case Report

EBV-associated lymphoproliferative disease post-CAR-T cell therapy

Epstein–Barr virus (EBV)-associated lymphoproliferative diseases (EBV-LPDs) are common complications that occur after solid organ transplantation or allogeneic hematopoietic stem-cell transplantation (HSCT). However, their occurrence and treatment …

verfasst von:: Shiyuan Zhang, Xiaoxi Zhou, Shangkun Zhang, Na Wang, Tongcun Zhang, Donghua Zhang, Qilin Ao, Yang Cao, Liang Huang

13.01.2024 | Review

Insights into optimizing exosome therapies for acute skin wound healing and other tissue repair

Exosome therapy holds great promise as a novel approach to improve acute skin wound healing. This review provides a comprehensive overview of the current understanding of exosome biology and its potential applications in acute skin wound healing …

verfasst von:: Tianjing Sun, Mo Li, Qi Liu, Anyong Yu, Kun Cheng, Jianxing Ma, Sean Murphy, Patrick Michael McNutt, Yuanyuan Zhang

02.01.2024 | Review

Unraveling the complex roles of macrophages in obese adipose tissue: an overview

Macrophages, a heterogeneous population of innate immune cells, exhibit remarkable plasticity and play pivotal roles in coordinating immune responses and maintaining tissue homeostasis within the context of metabolic diseases. The activation of …

verfasst von:: Chang Peng, Jun Chen, Rui Wu, Haowen Jiang, Jia Li

29.12.2023 | Research Article

Decitabine induces IRF7-mediated immune responses in p53-mutated triple-negative breast cancer: a clinical and translational study

p53 is mutated in half of cancer cases. However, no p53-targeting drugs have been approved. Here, we reposition decitabine for triple-negative breast cancer (TNBC), a subtype with frequent p53 mutations and extremely poor prognosis. In a …

verfasst von:: Haoyu Wang, Zhengyuan Wang, Zheng Wang, Xiaoyang Li, Yuntong Li, Ni Yan, Lili Wu, Ying Liang, Jiale Wu, Huaxin Song, Qing Qu, Jiahui Huang, Chunkang Chang, Kunwei Shen, Xiaosong Chen, Min Lu

29.12.2023 | Research Article

Multi-omics joint analysis revealed the metabolic profile of retroperitoneal liposarcoma

Retroperitoneal liposarcoma (RLPS) is the main subtype of retroperitoneal soft sarcoma (RSTS) and has a poor prognosis and few treatment options, except for surgery. The proteomic and metabolic profiles of RLPS have remained unclear. The aim of …

verfasst von:: Fu’an Xie, Yujia Niu, Lanlan Lian, Yue Wang, Aobo Zhuang, Guangting Yan, Yantao Ren, Xiaobing Chen, Mengmeng Xiao, Xi Li, Zhe Xi, Gen Zhang, Dongmei Qin, Kunrong Yang, Zhigang Zheng, Quan Zhang, Xiaogang Xia, Peng Li, Lingwei Gu, Ting Wu, Chenghua Luo, Shu-Hai Lin, Wengang Li

29.12.2023 | Comment

Human pangenome: far-reaching implications in precision medicine

verfasst von:: Yingyan Yu, Hongzhuan Chen

27.12.2023 | Research Article

Cross-sectional network analysis of plasma proteins/metabolites correlated with pathogenesis and therapeutic response in acute promyelocytic leukemia

The treatment of PML/RARA+ acute promyelocytic leukemia (APL) with all-trans-retinoic acid and arsenic trioxide (ATRA/ATO) has been recognized as a model for translational medicine research. Though an altered microenvironment is a general cancer …

verfasst von:: Niu Qiao, Yizhu Lyu, Feng Liu, Yuliang Zhang, Xiaolin Ma, Xiaojing Lin, Junyu Wang, Yinyin Xie, Ruihong Zhang, Jing Qiao, Hongming Zhu, Li Chen, Hai Fang, Tong Yin, Zhu Chen, Qiang Tian, Saijuan Chen

27.12.2023 | Review

Effects and mechanisms of acupuncture on women related health

Globally, public health interventions have resulted in a 30-year increase in women’s life expectancy. However, women’s health has not increased when socioeconomic status is ignored. Women’s health has become a major public health concern, for …

verfasst von:: Huichao Qin, Jiaxing Feng, Xiaoke Wu

15.12.2023 | Letter to Frontiers of Medicine

Microbiome subsets determine tumor prognosis and molecular characteristics of clear-cell renal cell carcinoma: a multi-center integrated analysis of microbiome, metabolome, and transcriptome data

verfasst von:: Wenjin Chen, Xiuwu Pan, Wang Zhou, Da Xu, Jiaxin Chen, Keqin Dong, Weijie Chen, Brian Rini, Xingang Cui

05.12.2023 | Research Article

Associations of sleeping patterns and isotemporal substitution of other behavior with the prevalence of CKD in Chinese adults

Studies have found a U-shaped relationship between sleep duration and chronic kidney disease (CKD) risk, but limited research evaluated the association of reallocating excessive sleep to other behavior with CKD. We included 104 538 participants …

verfasst von:: Yi Ding, Xiaoli Xu, Zhuojun Xin, Qiuyu Cao, Jiaojiao Huang, Xianglin Wu, Yanan Huo, Qin Wan, Yingfen Qin, Ruying Hu, Lixin Shi, Qing Su, Xuefeng Yu, Li Yan, Guijun Qin, Xulei Tang, Gang Chen, Min Xu, Tiange Wang, Zhiyun Zhao, Zhengnan Gao, Guixia Wang, Feixia Shen, Zuojie Luo, Li Chen, Qiang Li, Zhen Ye, Yinfei Zhang, Chao Liu, Youmin Wang, Tao Yang, Huacong Deng, Lulu Chen, Tianshu Zeng, Jiajun Zhao, Yiming Mu, Shengli Wu, Yuhong Chen, Jieli Lu, Weiqing Wang, Guang Ning, Yu Xu, Yufang Bi, Mian Li

22.11.2023 | Research Article

Association between ICU quality and in-hospital mortality of V-V ECMO-supported patients—the ECMO quality improvement action (EQIA) study: a national cohort study in China from 2017 to 2019

This cohort study was performed to explore the influence of intensive care unit (ICU) quality on in-hospital mortality of veno-venous (V-V) extracorporeal membrane oxygenation (ECMO)-supported patients in China. The study involved all V-V …

verfasst von:: Wei Cheng, Jieqing Chen, Xudong Ma, Jialu Sun, Sifa Gao, Ye Wang, Longxiang Su, Lu Wang, Wei Du, Huaiwu He, Yujie Chen, Zunzhu Li, Qi Li, Jianhua Sun, Hongbo Luo, Jinbang Liu, Guangliang Shan, Bing Du, Yanhong Guo, Dawei Liu, Chang Yin, Xiang Zhou, China National Critical Care Quality Control Center – the ECMO quality improvement action (EQIA) study

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