Waldenström macroglobulinemia (WM) is a rare indolent, low-grade B cell lymphoma that accounts for 1–2% of hematologic malignancies and is characterized by lymphoplasmacytic infiltration of the bone marrow and circulating monoclonal immunoglobulin …

T-cell lymphomas (TCLs) are a rare and diverse subgroup of non-Hodgkin lymphoma (NHL) characterized by the clonal expansion of mature T-lymphocytes. Traditionally, TCLs are classified into systemic peripheral T-cell lymphomas (PTCLs) which present …

Myelofibrosis (MF) is a progressive myeloproliferative neoplasm (MPN) characterized by bone marrow reticulin and/or collagen fibrosis with megakaryocytic proliferation and atypia [ 1 ]. Somatic driver mutations in JAK2 , CALR , or MPL occur in most …

Chronic myeloid leukemia (CML) is caused by the occurrence in the hematopoietic stem cell (HSC) pool of a reciprocal translocation between chromosome 9 and 22, the t(9;22)(q34;q11) [ 1 ]. This translocation generates a fusion between the BCR and …

Telomere biology disorders (TBDs) are multisystemic disorders which clinically present at degrees of organ involvement such as bone marrow failure (BMF), interstitial lung disease (ILD), non-regenerative hyperplasia (NRH) and/or cirrhosis, and T …

Telomere biology disorders (TBDs) are a heterogeneous group of genetic conditions characterized by accelerated aging of somatic cells due to prematurely shortened telomere lengths, frequently leading to organ dysfunction [ 1 •, 2 ]. They are also …