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Endocrine OnlineFirst articles

28.09.2022 | Original Article

Treatment with combined resveratrol and myoinositol ameliorates endocrine, metabolic alterations and perceived stress response in women with PCOS: a double-blind randomized clinical trial

Polycystic Ovary Syndrome (PCOS) is the prevalent heterogeneous endocrine-metabolic abnormality affecting 10–15% of women in their child bearing age. It is a many-faceted health issue identified by chronic oligo or anovulation, hyperandrogenism …

verfasst von:
Sehresh Hassan, Mohsin Shah, Muhammad Omar Malik, Ehtesham Ehtesham, Syed Hamid Habib, Bushra Rauf

27.09.2022 | Meta- Analysis

Thyroid hormone levels in Alzheimer disease: a systematic review and meta-analysis

Alzheimer disease (AD) is the most prevalent neurodegenerative and dementing condition in the world, mostly affecting the elderly population. Considering the fact that the incidence of AD is directly related to old age, it is expected to increase …

verfasst von:
Mahsa Dolatshahi, Arash Salehipour, Amene Saghazadeh, Hossein Sanjeari Moghaddam, Vajiheh Aghamollaii, Akbar Fotouhi, Abbas Tafakhori

24.09.2022 | Original Article

The combination of BRAFV600E mutation and Chinese Thyroid Imaging Reporting and Data System is helpful in the management of AUS/FLUS thyroid nodules

Ultrasound (US)-guided fine-needle aspiration (FNA) cytology is a reliable and effective diagnostic approach in patients with thyroid nodules (TNs) [ 1 ]. FNA can determine up to 70% of benign and 50% of malignant TNs without subjecting them to …

verfasst von:
Qiang Li, Lu Yang, Jianghong Lv, Lilong Xu, Murui Zhang, Shiyan Li

23.09.2022 | Original Article

Distress response in granulosa cells of women affected by PCOS with or without insulin resistance

Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age, with a prevalence of 6–10%, and is the leading cause of anovulatory infertility [ 1 ]. The pathophysiology of PCOS is complex and involves …

verfasst von:
Mauro Cozzolino, Sonia Herraiz, Yigit Cakiroglu, Juan Antonio Garcia-Velasco, Bulent Tiras, Alberto Pacheco, Susana Rabadan, Graciela Kohls, Ana Isabel Barrio, Antonio Pellicer, Emre Seli

23.09.2022 | Meta- Analysis

Ketogenic state improves testosterone serum levels—results from a systematic review and meta-analysis

Male hypogonadism is characterized by testosterone deficiency and a large spectrum of signs and symptoms, including sexual dysfunction, fatigue and decreased muscular strength and/or mass [ 1 ]. The exact estimation of male hypogonadism prevalence …

verfasst von:
Chiara Furini, Giorgia Spaggiari, Manuela Simoni, Carla Greco, Daniele Santi

22.09.2022 | Original Article

Cortex or cancellous—which is early for the decrease of bone content for vertebral body in health?

Osteoporosis is a skeletal disease that is characterized by low bone mass and micro-architectural deterioration of bone tissue, resulting in weakened bone strength and consequently higher fracture risk [ 1 – 3 ]. In the past 30 years, the risk rate …

verfasst von:
Lin Bai, Jujia Li, Congcong Ren, Ming Wang, Fan Yang, Qian Li, Jian Zhao, Ping Zhang

21.09.2022 | Original Article

2021 Asia-Pacific Graves’ Disease Consortium Survey of Clinical Practice Patterns in the Management of Graves’ Disease

Graves’ disease (GD) is the most common cause of hyperthyroidism [ 1 ], and its treatment is highly heterogeneous worldwide. The use of anti-thyroid drugs (ATD), radioactive iodine (RAI) or surgery is guided by local practices, based on …

verfasst von:
Rajeev Parameswaran, Mechteld Christine de Jong, James Lee Wai Kit, Kathleen Sek, Tran Quang Nam, Tran Viet Thang, Nguyen Thy Khue, Than Than Aye, Phone Myint Tun, Timothy Cole, Julie A. Miller, Michael Villa, Benjapa Khiewvan, Sirinart Sirinvaravong, Yong Lit Sin, Rohaizak Muhammad, Tjin Shing Jap, Amit Agrawal, Rajesh Rajput, Ranil Fernando, Manilka Sumanatilleke, Ketut Suastika, Young Kee Shong, Brian Lang, Luigi Bartalena, Samantha Peiling Yang, on behalf of the Asian Graves Consortium Study

21.09.2022 | COVID-19 | Original Article

Impact of the COVID-19 pandemic on the incidence, seasonal distribution, and characteristics of subacute thyroiditis

Subacute thyroiditis (SAT) is an inflammatory disease of the thyroid gland that mostly affects women (female to male ratio of 4:1), with peak incidence in the 4th and 5th decades of life [ 1 , 2 ]. Although it is a self-limiting pathology, neck …

verfasst von:
Hayri Bostan, Muhammed Erkam Sencar, Murat Calapkulu, Serdar Kayihan, Sema Hepsen, Aykut Cimsir, Umran Gul, Ilknur Ozturk Unsal, Ozgur Ozcelik, Muhammed Kizilgul, Bekir Ucan, Erman Cakal

20.09.2022 | Original Article

Mutation screening of eight genes and comparison of the clinical data in a Chinese cohort with congenital hypothyroidism

Congenital hypothyroidism (CH) is one of the frequent neonatal endocrine diseases and is characterized by irreversible intellectual disability and physical developmental disorder if left untreated, affecting 1 out of 3000 live births worldwide [ 1 …

verfasst von:
Liangshan Li, Xiaole Li, Xiaoyu Wang, Mengmeng Han, Dehua Zhao, Fang Wang, Shiguo Liu

Open Access 17.09.2022 | Original Article

Physiological linkage of thyroid and pituitary sensitivities

Thyroid function, and consequently thyroid hormone levels, are regulated predominantly by feedback control from the hypothalamus-pituitary [ 1 ]. Thyrotropin (TSH) released from the pituitary thyrotropes, under the influence of …

verfasst von:
Stephen Paul Fitzgerald, Nigel G. Bean, Henrik Falhammar, Rudolf Hoermann

16.09.2022 | Original Article

Acetate restores hypothalamic-adipose kisspeptin status in a rat model of PCOS by suppression of NLRP3 immunoreactivity

Reproductive disorders, including polycystic ovary syndrome (PCOS) is largely the cause of infertility in premenopausal women, causing 70–80% of infertility cases [ 1 , 2 ]. Globally, 6–21% of women of reproductive age is affected by PCOS [ 1 , 3 …

verfasst von:
Kehinde S. Olaniyi, Stephanie E. Areloegbe, Mosunmola B. Oyeleke

14.09.2022 | Original Article

MiR-203a-3p, miR-204-3p, miR-222-3p as useful diagnostic and prognostic tool for thyroid neoplasia spectrum

Neoplasias of the thyroid gland represent a spectrum of morphologically and biologically diverse lesions with very often overlapping histopathological features. As a consequence, they pose diagnostic difficulties for pathologists and doubts in …

verfasst von:
Stefana Stojanović, Zorana Dobrijević, Sonja Šelemetjev, Ilona Đorić, Jelena Janković Miljuš, Vladan Živaljević, Tijana Išić Denčić

12.09.2022 | Original Article

Effects of TSH suppressive therapy on bone mineral density (BMD) and bone turnover markers (BTMs) in patients with differentiated thyroid cancer in Northeast China: a prospective controlled cohort study

Differentiated thyroid cancer (DTC) is a common endocrine malignant tumor in the head and neck. In recent years, the incidence of thyroid cancer has increased rapidly and substantially in many countries, but the prognosis of DTC is favorable and …

verfasst von:
Shiwei Wang, Yu Wang, Li Zhu, Liang He, Mutian Lv, Hao Zhang, Haoyu Wang, Fan Zhang, Yaxin Lai, Yushu Li, Zhongyan Shan, Weiping Teng

09.09.2022 | Letter to the Editor

Diabetes technology and cybersecurity—a growing cause for concern

verfasst von:
Henrique Carmona Alexandrino, Marta Almeida Ferreira, Maria João Oliveira

08.09.2022 | Original Article

Pre- and peri-operative characteristics, complications and outcomes of patients with biochemically silent pheochromocytomas; a case series

Pheochromocytomas (PCs) and sympathetic paragangliomas (sPGLs) are rare neuroendocrine tumors, arising from chromaffin cells of the sympathoadrenal system, which autonomously synthesize and secrete catecholamines and their metabolites. According …

verfasst von:
Athanasios Fountas, Georgia Kanti, Spyridoula Glycofridi, Maria A. Christou, Athanasia Kalantzi, Irene Giagourta, Athina Markou, Georgia Ntali, Chrysanthi Aggeli, Eleftheria Saoulidou, Antonia Dimakopoulou, George N. Zografos, Theodora Kounadi, Stelios Tigas, Labrini Papanastasiou

08.09.2022 | Original Article

Incomplete response to therapy in intermediate- and high-risk thyroid cancer

In the last decade, the management of differentiated thyroid cancer (DTC) has undergone significant changes and is currently based on the estimated risk of recurrence and mortality [ 1 – 3 ]. The American thyroid Association (ATA) and the American …

verfasst von:
Ali S. Alzahrani, Noha Mukhtar

07.09.2022 | Original Article

Integrated analysis of novel macrophage related signature in anaplastic thyroid cancer

Although it accounts for just 1-2 percent of all thyroid cancers, anaplastic thyroid carcinoma (ATC) is one of the most aggressive cancers, with a median overall survival of 3–6 months [ 1 ]. For inoperable and metastatic ATCs, tumor debulking …

verfasst von:
Yi Luo, Yi-Chen Yang, Ben Ma, Wei-Bo Xu, Tian Liao, Yu Wang

07.09.2022 | Original Article

Identification of the collagen family as prognostic biomarkers in papillary thyroid carcinoma

Thyroid cancer is one of the malignancies with the fastest growth rate in recent years and is the most common malignant tumor of the endocrine system. Of these, papillary thyroid carcinoma is the most common type of pathology [ 1 , 2 ]. Most …

verfasst von:
Juntao Niu, Wenyu Guo, Yu-Zhou Chen, Ning Jiang

07.09.2022 | Original Article

Prognostic significance of lung metastasis-related finding in lenvatinib treatment for differentiated thyroid cancer

Thyroid cancer is the most common type of endocrine-related malignancy [ 1 ]. Papillary thyroid cancer and follicular thyroid cancer are types of differentiated thyroid cancer (DTC), and they account for >90% of all thyroid cancers [ 2 ]. DTC has a …

verfasst von:
Haruhiko Yamazaki, Hiroyuki Iwasaki, Katsuhiko Masudo, Soji Toda, Ai Matsui, Yasushi Rino

06.09.2022 | Original Article

Integrated bioinformatics analysis and screening of hub genes in polycystic ovary syndrome

Polycystic ovary syndrome (PCOS) is one of the most common endocrine and metabolic disorders, characterized by polycystic ovaries, hyperandrogenemia, hypermenorrhea, hyperinsulinemia, chronic anovulation, and metabolic disorders [ 1 – 3 ]. PCOS has …

verfasst von:
Gan Qiao, Jinshan Xing, Xin Luo, Chunxiang Zhang, Jingyan Yi