Journal of Gastrointestinal Cancer OnlineFirst articles

Open Access 24.04.2024 | Case Report

SMARCA4-Deficient Undifferentiated Esophageal Carcinoma: A Clinical Case Series and Literature Review

As of 2020, esophageal cancer (EC) was reported to rank seventh in incidence and sixth in overall mortality among cancers worldwide [ 1 ]. Esophageal squamous cell carcinoma (ESCC) and adenocarcinoma (EAC) are the two main types with 80% of cases …

verfasst von:: Faris Shweikeh, Gordon Hong, Jacob Walter, Matthew Hoscheit, Anthony Lembo, Mohamad Mouchli, Jason Lane

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18.04.2024 | Research

Impact of D2 Total Gastrectomy Including Splenectomy for Scirrhous Gastric Cancer in the Era of Effective Adjuvant Chemotherapy

Scirrhous gastric cancer (SGC), which is an uncommon type of gastric cancer, invades diffusely into the whole stomach and lymph nodes [ 1 , 2 ]. Since SGC had poor prognosis due to frequent peritoneal seeding and lymph node metastases, some …

verfasst von:: Yukinori Yamagata, Takaki Yoshikawa, Ryota Sakon, Kenichi Ishizu, Takeyuki Wada, Tsutomu Hayashi

12.04.2024 | Research

Study of Short-Term and Long-Term Outcomes Between Esophagogastrostomy and Double-Tract Reconstruction After Proximal Gastrectomy

The prevalence of gastric cancer is diminishing due to the decreased incidence of Helicobacter pylori infection and Westernization of diet and lifestyle in Japan. However, the rate of proximal gastric cancer, including esophagogastric junction …

verfasst von:: Tsuyoshi Hasegawa, Naoshi Kubo, Katsunobu Sakurai, Junya Nishimura, Yasuhito Iseki, Takafumi Nishii, Sadatoshi Shimizu, Toru Inoue, Yukio Nishiguchi, Kiyoshi Maeda

12.04.2024 | Research

Colorectal Adenosquamous Carcinoma: Demographics, Tumor Characteristics, and Survival Benefits of Surgery with Chemoradiation

Colorectal carcinomas are a group of malignancies that may occur anywhere along the colon and the rectum and account for 7.9% of new cancer cases in the United States [ 1 ]. The most common type of colorectal carcinoma is adenocarcinoma (AC), which …

verfasst von:: Asad Ullah, Guirshney Samarah Kenol, Kue Tylor Lee, Abdul Qahar Khan Yasinzai, Agha Wali, Abdul Waheed, Saleh Heneidi, Bhavishya U. Ramamoorthy, Nabin R. Karki, Andrew M. Blakely

09.04.2024 | Research

Role of the Clinical Features and MRI Parameters on Ki-67 Expression in Hepatocellular Carcinoma Patients: Development of a Predictive Nomogram

Hepatocellular carcinoma (HCC) is the most common type of liver cancer, accounting for approximately 90% of primary malignant tumors in the liver [ 1 ]. Unfortunately, the incidence rate of HCC continues to rise and it may soon surpass 1 million …

verfasst von:: Ming-ge Li, Shu-bin Luo, Ying-ying Hu, Lei Li, Hai-lian Lyu

08.04.2024 | Correspondence

Letter to the Editor: Comment on: Role of the Microbiome in the Diagnosis and Management of Gastroesophageal Cancers

verfasst von:: Jannis Kountouras, Evangelos Kazakos, Stergios A. Polyzos, Christos Zavos

02.04.2024 | Review

Laparoscopic Versus Open Gastrectomy for Advanced Gastric Cancer: A Meta-Analysis of Randomized Controlled Trials

Gastric cancer is one of the most prevalent cancers and a leading cause of mortality, ranking fifth among all malignant tumors worldwide [ 1 ]. Surgical resection with lymph node dissection is the most effective treatment for gastric cancer [ 2 ].

verfasst von:: Vinicius Bittar, Mauricio Ferreira Boneli, Pedro C. Abrahão Reis, Nicole Felix, Marcelo Antonio Pinheiro Braga, Kian M. Rocha, Leonardo O. Fogaroli, Gamaliel B. Costa, Ana Carolina Comini, Gustavo Amaral, Danyelle Cristine Marini, Marcos P. G. Camandaroba

01.04.2024 | Review

Aspirin in Patients with Viral Hepatitis: Systematic Review and Meta-Analysis of Observational Studies

Hepatocellular carcinoma is one of the most common malignant tumors throughout the world, ranking fourth among the causes of tumor death and possessing a high degree of malignancy, strong invasiveness and metastasis, poor prognosis, and a serious …

verfasst von:: Wentao Bian, Wenkai Bian, Qingyu Li, Yulian Li

28.03.2024 | Research

Publication Bias in Upper Gastrointestinal Oncology Clinical Trials

The persistent issue of publication bias in clinical research has been a concern in medical literature for several decades, with the first evaluations of this phenomenon dating back to the 1980s, which provided the first concrete evidence of its …

verfasst von:: Trenton Lippert, Erin Schmucker, Anchal Shukla, Ruha Reddy, Pooja Neerumalla, Gabriella Blanco, Vic Velanovich

26.03.2024 | Research

PD-L1 Expression in Colorectal Carcinoma Correlates with the Immune Microenvironment

Colorectal carcinoma (CRC) is the 3rd most common cancer worldwide in terms of its incidence, while 2nd in terms of mortality. The disease was more common in the developed nations compared to the developing ones. However, the incidence in …

verfasst von:: Mohammed Shahin, Susama Patra, Suvendu Purkait, Madhabananda Kar, Saroj Kumar Das Majumdar, Tushar Subhadarshan Mishra, Subash Chandra Samal, Hemanta Kumar Nayak

19.03.2024 | Research

Non-Alcoholic Fatty Liver Disease May Be a Risk Factor for Liver Metastasis After Radical Surgery for Colorectal Cancer: A Retrospective Study

Colorectal cancer (CRC) is the third most common cancer and has the second highest cancer-related mortality rate worldwide [ 1 ]. Although radical surgery and postoperative adjuvant therapy have progressed, approximately 30% of patients with CRC …

verfasst von:: Takashi Miyata, Yuki Shinden, Shota Motoyama, Yuta Sannomiya, Hozumi Tamezawa, Taigo Nagayama, Hisashi Nishiki, Akifumi Hashimoto, Daisuke Kaida, Hideto Fujita, Nobuhiko Ueda, Hiroyuki Takamura

15.03.2024 | Review

Atezolizumab and Bevacizumab Targeted-Therapy in Advanced Hepatocellular Carcinoma: A Systematic Review of Cost-effectiveness Analyses

Hepatocellular carcinoma (HCC) has one of the highest cancer-induced mortality rates worldwide, ranking fourth among cancer-related deceases [ 1 , 2 ]. HCC incidence is currently increasing in North and Latin America and Central Europe. HCC …

verfasst von:: Ghader Mohammadnezhad, Hadi Esmaily, Maryam Talebi, Matin Jafari

14.03.2024 | Case Report

Downstaging Hepatocellular Carcinoma with Checkpoint Inhibitor Therapy Improves Access to Curative Liver Transplant

Hepatocellular carcinoma (HCC) is the third most common cause of malignancy-related mortality. While resection may be curative, in the setting of advanced liver disease, recurrence is high. Transplantation may also be considered curative with low …

verfasst von:: Margaret C. Liu, Blanca Lizaola-Mayo, Channa R. Jayasekera, Amit K. Mathur, Nitin Katariya, Bashar Aqel, Thomas J. Byrne, David M. H. Chascsa

12.03.2024 | Research

Efficacy and Safety of TACE Combined with a Tyrosine Kinase Inhibitor for the Treatment of TACE-Refractory Hepatocellular Carcinoma: A Retrospective Comparative Study

Transarterial chemoembolization (TACE) is considered as the standard treatment for intermediate or locally advanced stage hepatocellular carcinoma (HCC) patients [ 1 , 2 ]. Nevertheless, 37–49.5% of patients have a poor or even no response to TACE …

verfasst von:: Yu-Xing Chen, Jin-Xing Zhang, Chun-Gao Zhou, Jin Liu, Sheng Liu, Hai-Bin Shi, Qing-Quan Zu, Yuan Cheng

04.03.2024 | Research

Hepatitis C Virus-Related One-Year Hepatocellular Carcinoma Recurrence After Directly Acting Antivirals: A Randomized Controlled Trial

Hepatocellular carcinoma (HCC) is the sixth and first most prevalent malignancy worldwide and in Egypt, respectively [ 1 ]. Globally, it is the fourth reason for malignancy-related mortality [ 2 ], while in Egypt, it is the most common cause of …

verfasst von:: Ahmed Kamal, Marwa Metawea, Heba Omar, Mahmoud Ghallab, Ahmed Kassem, Hend Naguib

01.03.2024 | Research

Biological Clock Genes are Crucial and Promising Biomarkers for the Therapeutic Targets and Prognostic Assessment in Gastric Cancer

Gastric cancer is the fifth most common cancer and the third most common cause of cancer death worldwide [ 1 ]. The pathogenesis of gastric cancer is a multi-step complex process caused by environmental and genetic factors. To date, although …

verfasst von:: Yonggang Tian, Yunqian Xie, Feihu Bai, Jun Wang, Dekui Zhang

27.02.2024 | Review

Role of the Microbiome in the Diagnosis and Management of Gastroesophageal Cancers

Stomach and esophageal cancers are among the highest mortality from cancers worldwide, ranking third and sixth, respectively [ 1 ]. Esophageal cancer can develop as a result of uncontrolled gastroesophageal reflux disease (GERD). Approximately 7% …

verfasst von:: Federica Mascaretti, Salman Haider, Chiara Amoroso, Flavio Caprioli, Daryl Ramai, Michele Ghidini

27.02.2024 | Review

The Prognostic Importance of Ki-67 in Gastrointestinal Carcinomas: A Meta-analysis and Multi-omics Approach

Gastrointestinal cancers (GI), which include esophageal carcinoma (ESCC), gastric cancer (GC), colorectal cancer (CRC), hepatocellular cancer (HC), and pancreatic cancer (PC), are responsible for more than one quarter of all tumor cases and a …

verfasst von:: Mahdieh Razmi, Fatemeh Tajik, Farideh Hashemi, Ayna Yazdanpanah, Fatemeh Hashemi-Niasari, Adeleh Divsalar

26.02.2024 | Research

Prognostic Significance of Sarcopenia and Systemic Inflammatory Markers in Biliary Tract Cancer: A Retrospective Cohort Study

Biliary tract cancer (BTC), including gallbladder carcinoma, intrahepatic cholangiocarcinoma, perihilar cholangiocarcinoma, distal cholangiocarcinoma, and ampullary carcinoma, is a rare aggressive malignancy that has been increasing in incidence …

verfasst von:: Masashi Utsumi, Masaru Inagaki, Koji Kitada, Naoyuki Tokunaga, Kosuke Yonoki, Yuya Sakurai, Hiroki Okabayashi, Ryosuke Hamano, Hideaki Miyasou, Yousuke Tsunemitsu, Shinya Otsuka

21.02.2024 | Brief Report

Characteristics and Outcomes of Patients with Cystic Fibrosis and Pancreatic Cancer: A Large Database Analysis

Cystic fibrosis (CF) is a chronic disease associated with life-limiting complications due to multiple organ damage. Advancements in diagnosis and treatment of CF have allowed improvement in overall survival over the last 3 decades [ 1 ]. As a …

verfasst von:: Srija Manchkanti, Shiva Jashwanth Gaddam, Udhayvir Singh Grewal

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