Hepatology International OnlineFirst articles

Open Access 16.04.2024 | Original Article

PIVKA-II combined with alpha-fetoprotein for the diagnostic value of hepatic tumors in children: a multicenter, prospective observational study

Although hepatic tumors rarely occur during childhood, they are associated with significantly higher morbidity and mortality in affected patients. Hepatoblastoma (HB) is the most common malignant hepatic tumor in children under the age of 3 years …

verfasst von:: Hongxiang Gao, Chenjie Xie, Jing Wang, Ji Ma, Shijian Liu, Li Xie, Yijie Zheng, Rui Dong, Shan Wang, Yongjun Fang, Yurui Wu, Xianwei Zhang, Xianying Lu, Yang Li, Weisong Li, Qiuhui Pan, Min Xu, Song Gu

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Open Access 09.04.2024 | Original Article

Efficacy and safety of precision-guided transjugular extrahepatic portosystemic shunt (TEPS) in the management of cavernous transformation of the portal vein with portal hypertension: a case series

Transjugular intrahepatic portosystemic shunt (TIPS) has emerged as a crucial therapeutic option for managing portal vein thrombosis (PVT) in liver cirrhosis [ 1 , 2 ]. TIPS effectively controls ascites, prevents esophageal varices rebleeding, and …

verfasst von:: Liu Zhang, Yi-Jiang Zhu, Xue-qing Wang, Rui-feng Wang, Li Dong, Liang Yin, Wei-Fu Lv, De-Lei Cheng, Chun-Ze Zhou

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09.04.2024 | Special supplement : MAFLD

MAFLD as part of systemic metabolic dysregulation

Nonalcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases worldwide. In recent years, a new terminology and definition of metabolic dysfunction-associated fatty liver disease (MAFLD) has been proposed. Compared to …

verfasst von:: Jing Zhao, Lu Liu, Ying-Ying Cao, Xin Gao, Giovanni Targher, Christopher D. Byrne, Dan-Qin Sun, Ming-Hua Zheng

05.04.2024 | Guidelines

APASL clinical practice guidelines on the management of acute kidney injury in acute-on-chronic liver failure

Acute-on-chronic liver failure (ACLF) is a syndrome that is characterized by the rapid development of organ failures predisposing these patients to a high risk of short-term early death. The main causes of organ failure in these patients are …

verfasst von:: Rakhi Maiwall, Satender Pal Singh, Paolo Angeli, Richard Moreau, Aleksander Krag, Virender Singh, Ashwani K. Singal, S. S. Tan, Puneet Puri, Mamun Mahtab, George Lau, Qin Ning, Manoj Kumar Sharma, P. N. Rao, Dharmesh Kapoor, Subhash Gupta, Ajay Duseja, Manav Wadhawan, Dinesh Jothimani, Sanjiv Saigal, Sunil Taneja, Akash Shukla, Pankaj Puri, Deepak Govil, Gaurav Pandey, Kaushal Madan, C. E. Eapen, Jaya Benjamin, Ashok Chowdhury, Shweta Singh, Vaishali Salao, Jin Mo Yang, Saeed Hamid, Shalimar, Sanjiv Jasuja, Anand V. Kulkarni, Madund A. Niriella, Harsh Vardhan Tevethia, Vinod Arora, R. P. Mathur, Akash Roy, Ankur Jindal, Neeraj Saraf, Nipun Verma, Arka De, Narendra S. Choudhary, Rohit Mehtani, Phool Chand, Omkar Rudra, Shiv Kumar Sarin

02.04.2024 | Original Article

Liver fibrosis showed a two-phase regression rate during long-term anti-HBV therapy by three-time biopsies assessments

Liver fibrosis and cirrhosis in chronic hepatitis B (CHB) patients are now considered to be reversible following sustained antiviral treatment as demonstrated by several clinical studies based on both short- and long-term antiviral treatment [ 1 – …

verfasst von:: Shuyan Chen, Jialing Zhou, Xiaoning Wu, Tongtong Meng, Bingqiong Wang, Hui Liu, Tailing Wang, Xinyan Zhao, Xinyu Zhao, Yuanyuan Kong, Xiaojuan Ou, Jidong Jia, Yameng Sun, Hong You

Open Access 27.03.2024 | Original Article

Evaluation of the histologic and immunohistochemical (CD34, glutamine synthetase) findings in idiopathic non-cirrhotic portal hypertension (INCPH)

Portal hypertension (PH) has various etiologies other than cirrhosis including prehepatic, hepatic, and posthepatic conditions [ 1 , 2 ]. When signs and symptoms of PH develop in the absence of liver cirrhosis, the condition is designated as …

verfasst von:: Melek Büyük, Neslihan Berker, Doğu Vurallı Bakkaloğlu, İbrahim Volkan Şenkal, Zerrin Önal, Mine Güllüoğlu

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26.03.2024 | Original Article

Global burden and trends of acute viral hepatitis among children and adolescents from 1990 to 2019: a systematic analysis of the Global Burden of Disease Study 2019

Viral hepatitis poses a significant global public health threat and is the primary cause of liver disease worldwide. It arises from five predominant hepatitis viruses: HAV, HBV, HCV, HDV, and HEV. Acute viral hepatitis (AVH) symptoms can range …

verfasst von:: Wanglong Xiao, Jingwei Zhao, Yiwen Chen, Xingzhu Liu, Chang Xu, Jiaxu Zhang, Yongbing Qian, Qiang Xia

16.03.2024 | Review Article

Prophylaxis of hepatic encephalopathy: current and future drug targets

Hepatic encephalopathy is described by a broad spectrum of neurological and psychiatric aberrations resulting due to advanced liver dysfunction. It is a neurological disorder due to hepatic insufficiency and/or portosystemic shunts. Its clinical …

verfasst von:: Sudhir Maharshi, Barjesh Chander Sharma

15.03.2024 | Original Article

Safety of right liver donation after improving steatosis through weight loss in living donors: a retrospective study

The incidence of obesity has dramatically increased worldwide over the past few decades. As the obesity rates continue to rise, hepatic steatosis (HS) has become increasingly common in both living and deceased donors. Some studies have …

verfasst von:: Young-In Yoon, Sung-Gyu Lee, Shin Hwang, Ki-Hun Kim, Chul-Soo Ahn, Deok-Bog Moon, Tae-Yong Ha, Gi-Won Song, Dong-Hwan Jung, Gil-Chun Park

14.03.2024 | Original Article

Laparoscopic liver resection is superior to radiofrequency ablation for small hepatocellular carcinoma: a systematic review and meta-analysis of propensity score-matched studies

Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide and the incidence of HCC has doubled in the last 20 years, which makes it the third leading cause of cancer-related deaths worldwide [ 1 ]. Hepatectomy, hepatic artery …

verfasst von:: Wen Chen, Xiaodan Lin, Zhenheng Wu, Wei Pan, Qiming Ke, Yanling Chen

Open Access 13.03.2024 | Letter to the Editor

“Dosis sola facit venenum”—Evidence for causality in the association between ketamine and cholestatic liver injury

verfasst von:: Pedro David Wendel-Garcia, Rea Andermatt, Christian Bode, Sascha David, Klaus Stahl

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12.03.2024 | Review Article

Surgical risk stratification in patients with cirrhosis

Individuals with cirrhosis experience higher morbidity and mortality rates than the general population, irrespective of the type or scope of surgery. This increased risk is attributed to adverse effects of liver disease, encompassing coagulation …

verfasst von:: Ana Ostojic, Nadim Mahmud, K. Rajender Reddy

09.03.2024 | Guidelines

Expert consensus on the diagnosis and treatment of end-stage liver disease complicated by infections

End-stage liver disease (ESLD) is a life-threatening clinical syndrome and when complicated with infection the mortality is markedly increased. In patients with ESLD, bacterial or fungal infection can induce or aggravate the occurrence or …

verfasst von:: Tao Chen, Guang Chen, Guiqiang Wang, Sombat Treeprasertsuk, Cosmas Rinaldi Adithya Lesmana, Han-Chieh Lin, Mamun Al-mahtab, Yogesh K. Chawla, Soek-Siam Tan, Jia-Horng Kao, Man-Fung Yuen, Guan-Huei Lee, Diana Alcantara-Payawal, Nobuaki Nakayama, Zaigham Abbas, Wasim Jafri, Dong-Joon Kim, Ashok Choudhury, Rakhi Mahiwall, Jinlin Hou, Saeed Hamid, Jidong Jia, J. S. Bajaj, Fusheng Wang, Shiv K. Sarin, Qin Ning

Open Access 09.03.2024 | Original Article

Predictors of HBsAg seroclearance in patients with chronic HBV infection treated with pegylated interferon-α: a systematic review and meta-analysis

Hepatitis B virus (HBV) infection is a significant global public health issue. According to the World Health Organization (WHO), approximately 296 million people suffer from chronic HBV infection, and there are 1.5 million new infections each year …

verfasst von:: Shaowen Jiang, Simin Guo, Yan Huang, Yalin Yin, Jingwen Feng, Huijuan Zhou, Qing Guo, Weijing Wang, Haiguang Xin, Qing Xie

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07.03.2024 | Letter to the Editor

Impact of chronic hepatitis B and concurrent steatosis on the risk of hepatocellular carcinoma

verfasst von:: Ibrahim Ayada, Jiajing Li, Willem Pieter Brouwer, Robert J. de Knegt, Qiuwei Pan

07.03.2024 | Editorial

Are dairy products the answer to metabolic dysfunction-associated fatty liver disease?

verfasst von:: Kristopher Cho-Hei Lau, Vincent Wai-Sun Wong

07.03.2024 | Correction

Correction to: Complementary role of peripheral and central autonomic nervous system on insulin-like growth factor-1 activation to prevent fatty liver disease

verfasst von:: Itsuo Nagayama, Kenya Kamimura, Takashi Owaki, Masayoshi Ko, Takuro Nagoya, Yuto Tanaka, Marina Ohkoshi, Toru Setsu, Akira Sakamaki, Takeshi Yokoo, Hiroteru Kamimura, Shuji Terai

01.03.2024 | Original Article

Pre-hepatectomy dynamic circulating tumor DNA to predict pathologic response to preoperative chemotherapy and post-hepatectomy recurrence in patients with colorectal liver metastases

Colorectal cancer (CRC) is the second most frequent cause of cancer-related death worldwide and ranks as the fifth leading cause of cancer death in China [ 1 , 2 ]. Around 30–50% patients with CRC develop liver metastases during the course of their …

verfasst von:: Ming Liu, Quan Bao, Tingting Zhao, Longfei Huang, Danhua Zhang, Yanyan Wang, Xiaoluan Yan, Hongwei Wang, Kemin Jin, Wei Liu, Kun Wang, Baocai Xing

08.02.2024 | Letter to the Editor

Is TACE plus tyrosine kinase inhibitors and immune checkpoint inhibitors superior to TACE plus tyrosine kinase inhibitors for unresectable hepatocellular carcinoma: the debate continues

verfasst von:: Shiye Yang, Huoqi Liang, Xing Li, Jiayi Qian, Zhibing Ming

Open Access 08.02.2024 | Original Article

FXR-FGF19 signaling in the gut–liver axis is dysregulated in patients with cirrhosis and correlates with impaired intestinal defence

Farnesoid X receptor (FXR) is the most important endogenous receptor for bile acids (BA) and highly expressed in the liver and intestines [ 1 ]. FXR signaling modulates the synthesis and enterohepatic circulation of BAs, hepatic inflammation and …

verfasst von:: Benedikt Simbrunner, Benedikt S. Hofer, Philipp Schwabl, Kerstin Zinober, Oleksandr Petrenko, Claudia Fuchs, Georg Semmler, Rodrig Marculescu, Mattias Mandorfer, Christian Datz, Michael Trauner, Thomas Reiberger

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Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

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