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Annals of Nuclear Medicine OnlineFirst articles

24.04.2024 | Original Article

Safety and efficacy of multiple-dose versus single-dose MIBG therapy in patients with refractory pheochromocytoma and paraganglioma: a single-center retrospective analysis

Pheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumors originating from neural crest cells. Those arising from the adrenal medulla are referred to as pheochromocytomas, while those originating outside the adrenal glands from …

verfasst von:
Naoto Wakabayashi, Shiro Watanabe, Takashige Abe, Junki Takenaka, Kenji Hirata, Rina Kimura, Keita Sakamoto, Nobuo Shinohara, Kohsuke Kudo

22.04.2024 | Original Article

Increase of prostate-specific antigen doubling time predicts survival in metastatic castration-resistant prostate cancer patients undergoing radium therapy

Prostate cancer ranks among the most prevalent malignancies in men, contributing significantly to the global cancer burden, with an estimated incidence rate of 1104 per million in 2020 [ 1 ]. Metastatic castration-resistant prostate cancer (mCRPC) …

verfasst von:
Hsi-Huei Lu, Nan-Tsing Chiu, Mu-Hung Tsai

22.04.2024 | Original Article

Use of dose–volume histograms for metabolic response prediction in hepatocellular carcinoma patients undergoing transarterial radioembolization with Y-90 resin microspheres

Transarterial radioembolization (TARE), also known as selective internal radiation therapy (SIRT), is a safe and effective therapeutic approach for unresectable liver tumors, particularly hepatocellular carcinoma. The treatment strategy in TARE is …

verfasst von:
Nazim Coskun, Mehmet Oguz Kartal, Aysenur Sinem Kartal, Velihan Cayhan, Mustafa Ozdemir, Murat Canyigit, Elif Ozdemir

11.04.2024 | Original Article

No prognostic impact of staging bone scan in patients with stage IA non-small cell lung cancer

Non-small cell lung cancer (NSCLC) accounts for approximately 80–85% of lung cancer cases [ 1 ]. Distant metastasis is the leading cause of death in NSCLC, and bone is one of the common sites of distant metastasis in this type of cancer [ 2 – 5 ].

verfasst von:
Xia Zheng, Chunxia Li, Jing Ai, Guili Dong, Man Long, Mingyi Li, Shilin Qiu, Yanni Huang, Guangjun Yang, Tao Zhang, Zhenhui Li

08.04.2024 | Original Article

Diagnostic performance of a deep-learning model using 18F-FDG PET/CT for evaluating recurrence after radiation therapy in patients with lung cancer

Lung cancer is one of the leading causes of death from cancer worldwide and the overall 5-year survival rate of patients with lung cancer is 17.4% [ 1 , 2 ]. The standard treatment for patients with lung cancer is surgery, but radiation therapy …

verfasst von:
Changhwan Sung, Jungsu S. Oh, Byung Soo Park, Su Ssan Kim, Si Yeol Song, Jong Jin Lee

Open Access 04.04.2024 | Original Article

The effect of harmonization on the variability of PET radiomic features extracted using various segmentation methods

Cancer is a leading cause of death worldwide and a significant barrier to increasing life expectancy [ 1 ]. According to the 2019 report World Health Organization (WHO) [ 2 ], the first or second primary reason for mortality in people under 70 is …

verfasst von:
Seyyed Ali Hosseini, Isaac Shiri, Pardis Ghaffarian, Ghasem Hajianfar, Atlas Haddadi Avval, Milad Seyfi, Stijn Servaes, Pedro Rosa-Neto, Habib Zaidi, Mohammad Reza Ay

04.04.2024 | Original Article

Parametric net influx rate imaging of 68Ga-DOTATATE in patients with neuroendocrine tumors: assessment of lesion detectability

Neuroendocrine tumor (NET) is a heterogeneous neoplasm that originates from neuroendocrine cells and has become increasingly prevalent [ 1 , 2 ]. As NETs express high levels of somatostatin receptors (SSTRs), they can be imaged using 68 …

verfasst von:
Hongyan Yin, Guobing Liu, Wujian Mao, Jing Lv, Haojun Yu, Dengfeng Cheng, Liang Cai, Hongcheng Shi

02.04.2024 | Original Article

Examination of iatrogenic FDG accumulation after COVID-19 vaccination

The spread of coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, has led to a global vaccination campaign [ 1 ]. Following vaccine injection into the deltoid muscle (DM), a physiological immunogenic response occurs, leading to reactive …

verfasst von:
Keiko Takahashi, Osamu Manabe, Kazuya Shizukuishi, Hirohumi Shibata, Hiroki Kawakami, Akira Otsuka, Noriko Oyama-Manabe

Open Access 27.03.2024 | Original Article

18F-FDG PET/CT metabolism multi-parameter prediction of chemotherapy efficacy in locally progressive gastric cancer

In 2022, the World Health Organization ranked the incidence of gastric cancer as third and fifth most in China and worldwide, respectively, with incidence and mortality rates accounting for 10.6% and 12.5% of cancer cases in China, for 5.6% and …

verfasst von:
Luqiang Jin, Linghe Zhang, Liping Fu, Fahuan Song, Aiping Cheng

22.03.2024 | Original Article

Evaluation of two-dimensional total bone uptake (2D-TBU) and bone scan index (BSI) extracted from active bone metastatic burden on the bone scintigraphy in patients with radium-223 treatment

It is estimated that almost 1.4 million new cases of prostate cancer appear every year, making it the second most frequent cancer among men worldwide [ 1 ]. Because prostate cancer causes bone metastasis at a high rate, its control and management …

verfasst von:
Shohei Fukai, Hiromitsu Daisaki, Takuro Umeda, Naoki Shimada, Takashi Terauchi, Mitsuru Koizumi

Open Access 21.03.2024 | Original Article

Comparison of consistency in centiloid scale among different analytical methods in amyloid PET: the CapAIBL, VIZCalc, and Amyquant methods

Quantitative analysis in amyloid positron emission tomography (PET) is expected to allow a continuous measure of amyloid burden, which can be used to complement dichotomous visual reads. Quantification may facilitate comparisons between different …

verfasst von:
Cong Shang, Keita Sakurai, Takashi Nihashi, Yutaka Arahata, Akinori Takeda, Kazunari Ishii, Kenji Ishii, Hiroshi Matsuda, Kengo Ito, Takashi Kato, Hiroshi Toyama, Akinori Nakamura, BATON Study Group

Open Access 19.03.2024 | Original Article

Novel indices representing heterogeneous distributions of myocardial perfusion imaging

The various heterogeneous distributions in myocardial perfusion images (MPI) of 99m Tc-methoxyisobutylisonitrile (MIBI) are observed in patients with cardiac diseases. For relatively prominent and localized myocardial perfusion abnormalities, it is …

verfasst von:
Misato Chimura, Tomohito Ohtani, Fusako Sera, Rie Higuchi, Kenji Kajitani, Kenichi Nakajima, Yasushi Sakata

18.03.2024 | Original Article

Prognostic value of left ventricular mechanical dyssynchrony indices derived from gated myocardial perfusion SPECT in coronary artery disease: a systematic review and meta-analysis

Left ventricular mechanical dyssynchrony (LVMD) is a condition characterized by disparities in activation and contraction timing between different segments of myocardium [ 1 ]. It is commonly observed in patients with various cardiomyopathies …

verfasst von:
Koeun Lee, Sangwon Han, Jeongryul Ryu, Sang-Geon Cho, Dae Hyuk Moon

Open Access 13.03.2024 | Original Article

Flare phenomenon visualized by 99mTc-bone scintigraphy has prognostic value for patients with metastatic castration-resistant prostate cancer

Prostate cancer is the second most prevalent type of malignancy among men, with a mortality rate of 6.8% and a particularly high prevalence in Americas, Oceania, most parts in Africa, western Europe, and Japan [ 1 ]. About 10‒15 months after …

verfasst von:
Xue Zhang, Kenichi Nakajima, Atsushi Mizokami, Hiroyuki Horikoshi, Koshiro Nishimoto, Katsuyoshi Hashine, Hideyasu Matsuyama, Satoru Takahashi, Hiroshi Wakabayashi, Seigo Kinuya

11.03.2024 | Original Article

Quantitative analysis of abdominal aortic blood flow by 99mTc-DTPA renal scintigraphy in patients with heart failure

Renal insufficiency is a significant predictor of adverse outcomes in patients with heart failure (HF), emphasizing the need for precise renal functional evaluations [ 1 ]. Renal scintigraphy is an established method that accurately assesses renal …

verfasst von:
Yue Li, Zhiqiang Yang, Pei Yin, Xian Gao, Lizhuo Li, Qingzhen Zhao, Yuzhi Zhen, Yu Wang, Chao Liu

30.10.2019 | Review Article

Nuclear oncology as seen by me in Japan: a historical review and future perspective

Since 1964 the author has seen and experienced the progress of nuclear medicine in Japan. The purpose of this review article is to trace the application of radiopharmaceuticals and instruments for the diagnosis of tumors and treatment of cancers …

verfasst von:
Yasuhito Sasaki

14.10.2019 | Original Article

Maximum standardized uptake value from quantitative bone single-photon emission computed tomography/computed tomography in differentiating metastatic and degenerative joint disease of the spine in prostate cancer patients

Early diagnosis of bone metastasis is essential in prostate cancer to aid the referring physician in choosing the appropriate therapy, assessing the extent of bony involvement, monitoring of treatment response and assessing for possible …

verfasst von:
Mohd Fazrin Mohd Rohani, Norazlina Mat Nawi, Syed Ejaz Shamim, Wan Fatihah Wan Sohaimi, Wan Mohd Nazlee Wan Zainon, Marianie Musarudin, Mohamad Aminudin Said, Hazlin Hashim