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Annals of Nuclear Medicine OnlineFirst articles

01.02.2023 | Original Article

PET-guided attention for prediction of microvascular invasion in preoperative hepatocellular carcinoma on PET/CT

Hepatocellular carcinoma (HCC) is one of the most common malignant diseases [ 1 ]. Several studies have shown that microvascular invasion (MVI) is an important prognostic factor for HCC patients [ 1 , 2 ]. The existence of MVI in HCC patients …

verfasst von:
Zhengjie Ye, Jian Zhang, Nan Wu, Song Chen, Yutao Wang, Zhongfei Yu, Wei Jin

25.01.2023 | Acknowledgment to Reviewers

Acknowledgements to Reviewers

Open Access 19.01.2023 | Original Article

Effect of scan-time shortening on the 11C-PHNO binding potential to dopamine D3 receptor in humans and test–retest reliability

The dopamine D 3 receptor (D 3 R) was cloned about 30 years ago [ 1 ]. In the central nervous system (CNS), D 3 R is expressed in regions such as the pallidum, ventral striatum (VST), substantia nigra (SN) and hypothalamus [ 2 – 8 ]. The D 3 R is …

verfasst von:
Keiko Matsunaga, Misato Tonomura, Kohji Abe, Eku Shimosegawa

06.01.2023 | Original Article

18F-FP-CIT dopamine transporter PET findings in the striatum and retina of type 1 diabetic rats

Dopamine (DA) is one of the crucial monoamine neurotransmitter in both brain and retina, since it supports motor control, cognitive function or visual function [ 1 ]. Numerous evidences have confirmed that diabetes mellitus (DM) has profound …

verfasst von:
Ping Chen, Jun Li, Zhan Li, Duxia Yu, Ning Ma, Zian Xia, Xianglei Meng, Xingdang Liu

Open Access 06.01.2023 | Invited Review Article

A review of harmonization strategies for quantitative PET

PET can reveal in vivo biological processes at the molecular level. PET-derived quantitative values have been used as a surrogate marker for clinical decision-making in numerous clinical studies and trials. However, quantitative values in PET are …

verfasst von:
Go Akamatsu, Yuji Tsutsui, Hiromitsu Daisaki, Katsuhiko Mitsumoto, Shingo Baba, Masayuki Sasaki

31.12.2022 | Original Article

99mTc-Rituximab sentinel lymph node mapping and biopsy, the effective technique avoids axillary dissection and predicts prognosis in 533 cutaneous melanoma

Melanoma accounts for the vast majority of skin cancer related deaths (almost 90%) [ 1 ]. It is important to assess the status of regional lymph nodes (LNs) since melanoma often metastasizes through regional lymphatic channels. The technique of …

verfasst von:
Nan Li, Xin Zhou, Hua Zhu, Fei Wang, Rui Guo, Yan Zhang, Yufei Song, Shizhen Zhai, Qing Xie, Jiayong Liu, Zhongwu Li, Zhi Yang

31.12.2022 | Original Article

Brain imaging of sequential acquisition using a flexible PET scanner and 3-T MRI: quantitative and qualitative assessment

PET/CT has become widely used in clinical practice because it successfully combines the superior metabolic information obtained by PET with anatomical information from CT [ 1 , 2 ]. PET/MRI has been introduced into the clinical setting and shows …

verfasst von:
Satoshi Nakajima, Yasutaka Fushimi, Takuya Hinoda, Akihiko Sakata, Sachi Okuchi, Yoshiki Arakawa, Takayoshi Ishimori, Yuji Nakamoto

21.12.2022 | Original Article

Incidence of renal scarring on technetium-99 m dimercaptosuccinic acid renal scintigraphy after acute pyelonephritis, acute focal bacterial nephritis, and renal abscess

Pediatric urinary tract infections are commonly encountered in the emergency department. The goal of treatment for urinary tract infections is to prevent complications such as chronic renal failure or secondary hypertension [ 1 – 6 ]. To predict …

verfasst von:
Takahiro Hosokawa, Mayuki Uchiyama, Yutaka Tanami, Yumiko Sato, Yasuharu Wakabayashi, Eiji Oguma

20.12.2022 | Original Article

Invasive mucinous adenocarcinoma of the lung: clinicopathological features, 18F-FDG PET/CT findings, and survival outcomes

Invasive mucinous adenocarcinoma (IMA) is a rare subtype of lung adenocarcinoma (ADC), which accounts for approximately 2–10% of lung ADCs [ 1 – 3 ]. This concept of lung mucinous adenocarcinoma was first introduced by Kish et al. in a case report …

verfasst von:
Xiaolin Sun, Baozhen Zeng, Xiaoyue Tan, Zhijian Chen, Xiaoqiang Pan, Lei Jiang

Open Access 17.12.2022 | Original Article

Prognostic value of semi-quantitative parameters of 18F-FDG PET/CT in newly diagnosed multiple myeloma patients

Plasma cell tumors are plasma cell malignancies characterized by the abnormal proliferation of primary malignant plasma cells in the bone marrow and the production of monoclonal immunoglobulins [ 1 ]. According to the difference of serum abnormal …

verfasst von:
Baoyu Wan, Song Zhang, Peng Wang, Pengyi Deng, Wenli Dai

05.12.2022 | Original Article

Melissa Officinalis L. aqueous extract pretreatment decreases methotrexate-induced hepatotoxicity at lower dose and increases 99mTc-phytate liver uptake, as a probe of liver toxicity assessment, in rats

Methotrexate (MTX) is one of the folate antagonists used in the treatment of malignant and non-malignant diseases including acute lymphoblastic leukemia, breast cancer, head and neck cancer, lung cancer, osteosarcoma, rheumatoid arthritis …

verfasst von:
Somayeh Shahani, Nasrin Mehraban, Fereshteh Talebpour Amiri, Seyed Mohammad Abedi, Zohreh Noaparast, Salam Mohammadinia

27.11.2022 | Original Article

The evaluation of DLCO changes in patients with relatively higher lung shunt fractions receiving TARE

In the last 10 years, transarterial radioembolization (TARE), using Yttrium-90 ( 90 Y) labeled microspheres which are infused through the hepatic arteries has arisen for locoregional treatment of inoperable primary or metastatic liver tumors [ 1 …

verfasst von:
Ceren O. Engur, Salih Ozguven, Efe Soydemir, Emel Eryuksel, Feyza Sen, Halil T. Turoglu, Cagatay Cimsit, Tanju Y. Erdil, Tunc Ones

27.11.2022 | Original Article

Glucose metabolic heterogeneity correlates with pathological features and improves survival stratification of resectable lung adenocarcinoma

Lung cancer was the second most commonly diagnosed cancer and the leading cause of cancer-related mortality worldwide in 2020 [ 1 ]. Among all histopathological types of lung cancer, the incidence of adenocarcinoma has risen since 30 years, and it …

verfasst von:
Yu-Hung Chen, Yen-Chang Chen, Kun-Han Lue, Sung-Chao Chu, Bee-Song Chang, Ling-Yi Wang, Ming-Hsun Li, Chih-Bin Lin

25.11.2022 | Original Article

Reproducibility assessment of uptake on dedicated breast PET for noise discrimination

The incidence and mortality of breast cancer in women have continuously increased over the last 2 decades [ 1 ]. Breast cancer was the leading cause of global cancer incidence in 2020, accounting for 11.7% of all cancer cases, and is the …

verfasst von:
Shunsuke Yuge, Kanae K. Miyake, Takayoshi Ishimori, Masako Kataoka, Yoshiaki Matsumoto, Koji Fujimoto, Tomoharu Sugie, Masakazu Toi, Yuji Nakamoto

Open Access 21.11.2022 | Original Article

Dosimetry and efficacy of a tau PET tracer [18F]MK-6240 in Japanese healthy elderly and patients with Alzheimer’s disease

Tau is the primary protein composing neurofibrillary tangles (NFT). Unlike β-amyloid deposition, post-mortem studies have shown that NFT density correlates with neurodegeneration and cognitive impairment [ 1 – 4 ]. Thus, PET imaging agents that …

verfasst von:
Akihito Ohnishi, Go Akamatsu, Yasuhiko Ikari, Hiroyuki Nishida, Keiji Shimizu, Keiichi Matsumoto, Kazuki Aita, Masahiro Sasaki, Yasuji Yamamoto, Tomohiko Yamane, Michio Senda

15.11.2022 | Original Article

Evaluation of standardized uptake value on 131I-6β-iodomethyl-19-norcholesterol scintigraphy for diagnosis of primary aldosteronism and correspondence with adrenal venous sampling

Primary aldosteronism (PA) is a condition characterized by hypertension and hypokalemia and caused by autonomous hypersecretion of the mineralocorticoid aldosterone from the adrenal glands, which damages the cardiovascular and central nervous …

verfasst von:
Tomohiro Sato, Norikazu Matsutomo, Tomoaki Yamamoto, Mitsuha Fukami, Takashi Kono

10.11.2022 | Original Article

Comparison of 1-h with 3-h planar 99mTc-pyrophosphate scintigraphy in patients with suspected transthyretin cardiac amyloidosis using SPECT as a reference standard

Technetium-99m pyrophosphate (PYP) imaging has been increasingly used for the non-invasive diagnosis of transthyretin cardiac amyloidosis (ATTR-CA) [ 1 , 2 ]. The recent expert consensus recommendations for multimodal imaging in cardiac amyloidosis …

verfasst von:
Toshinori Saitou, Tadao Aikawa, Osamu Manabe, Atsushi Nagase, Tamaki Kudo, Noriko Oyama-Manabe

30.10.2019 | Review Article

Nuclear oncology as seen by me in Japan: a historical review and future perspective

Since 1964 the author has seen and experienced the progress of nuclear medicine in Japan. The purpose of this review article is to trace the application of radiopharmaceuticals and instruments for the diagnosis of tumors and treatment of cancers …

verfasst von:
Yasuhito Sasaki

14.10.2019 | Original Article

Maximum standardized uptake value from quantitative bone single-photon emission computed tomography/computed tomography in differentiating metastatic and degenerative joint disease of the spine in prostate cancer patients

Early diagnosis of bone metastasis is essential in prostate cancer to aid the referring physician in choosing the appropriate therapy, assessing the extent of bony involvement, monitoring of treatment response and assessing for possible …

verfasst von:
Mohd Fazrin Mohd Rohani, Norazlina Mat Nawi, Syed Ejaz Shamim, Wan Fatihah Wan Sohaimi, Wan Mohd Nazlee Wan Zainon, Marianie Musarudin, Mohamad Aminudin Said, Hazlin Hashim