Immunotherapies have significantly improved outcomes in patients with multiple myeloma yet maintaining a durable response in heavily pretreated patients remains challenging. Therapies that target B cell maturation antigen (BCMA) provide additional …
Generalized myasthenia gravis (gMG) is a rare, chronic, neuromuscular autoimmune disease, mediated by pathogenic immunoglobulin auto-antibodies targeting the neuromuscular junction [ 1 ]. gMG is a debilitating disease that negatively impacts …
verfasst von:
Cécile van Steen, Lorenzo Celico, Erik Spaepen, Tim Hagenacker, Sven G. Meuth, Tobias Ruck, A. Gordon Smith, Danielle H. Bodicoat, Maria de Francesco, Sergio Iannazzo
Despite increased oral screening programs and advances in diagnostic modalities in detecting oral cancers at an early stage, a disproportionately high number of patients are still diagnosed in advanced stages [ 1 – 3 ]. Nearly 55% of patients with …
verfasst von:
Ameya A. Asarkar, Brent A. Chang, Remco de Bree, Luiz P. Kowalski, Orlando Guntinas-Lichius, Patrick J. Bradley, Pim de Graaf, Primož Strojan, Karthik N. Rao, Antti A. Mäkitie, Fernando López, Alessandra Rinaldo, Carsten Palme, Eric M. Genden, Alvaro Sanabria, Juan P. Rodrigo, Alfio Ferlito
Irritable bowel syndrome (IBS) with diarrhea (IBS-D) is a common, chronic, relapsing, and potentially severe disorder of gut–brain interaction (DGBI) characterized by troublesome symptoms such as abdominal pain, diarrhea, fecal urgency, and …
verfasst von:
Brian E. Lacy, Patrick Gagnon-Sanschagrin, Zeev Heimanson, Rebecca Bungay, Remi Bellefleur, Annie Guérin, Brock Bumpass, Danellys Borroto, George Joseph, Ankur A. Dashputre
Hemophilia A (HA), a rare X-linked recessive bleeding disorder caused by a deficiency of coagulation factor VIII (FVIII) protein [ 1 ], affects approximately 17.1 per 100,000 male individuals worldwide [ 2 ]. Standard of care (SOC) for individuals …
verfasst von:
Johannes Oldenburg, Herve Chambost, Hai Liu, Charles Hawes, Xiaojun You, Xinqun Yang, Vanessa Newman, Tara M. Robinson, Anthony J. Hatswell, David Hinds, Sandra Santos, Margareth Ozelo
Coronary artery bypass grafting (CABG) is an important revascularization treatment for patients with coronary artery disease [ 1 ]. Previously, cardiopulmonary bypass (CPB) was required during the CABG (on-pump CABG) and might result in …
verfasst von:
Yang Yan, Changying Zhao, Jialan Niu, Pengyun Yan, Jing Li, Duolao Wang, Guoliang Li
Gastric cancer is the fifth most common malignancy and the fourth leading cause of cancer death worldwide, with 1.09 million new cases and 0.77 million deaths in 2020 [ 1 ]. There is a heavy burden of gastric cancer in Eastern Asia, which has the …
Inflammatory bowel disease (IBD) comprises ulcerative colitis (UC) and Crohn’s disease (CD), both of which are chronic, relapsing and debilitating conditions with a disease course that may range in severity and progression [ 1 – 3 ]. In Italy, the …
Type 2 diabetes (T2D) is a significant health concern in the USA with > 30 million adults diagnosed with the disease [ 1 ]. The already high prevalence of T2D is expected to increase by almost 50% globally by 2045 [ 2 ]. About one in four people …
verfasst von:
Katia L. Hannah, Poorva M. Nemlekar, Courtney R. Green, Gregory J. Norman
Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, life-threatening disease characterized by complement-mediated hemolysis and thrombosis [ 1 ]. Patients with PNH have an acquired mutation in PIG-A , leading to the lack of …
verfasst von:
Christopher J. Patriquin, Andrija Bogdanovic, Morag Griffin, Richard J. Kelly, Jaroslaw P. Maciejewski, Brian Mulherin, Régis Peffault de Latour, Alexander Röth, Veena Selvaratnam, Jeffrey Szer, Mohammed Al-Adhami, Regina Horneff, Lisa Tan, Michael Yeh, Jens Panse
Wilson disease (WD) is an inherited autosomal recessive metabolic disorder of impaired copper transport. WD causes an accumulation of copper in multiple organs, namely the liver and brain, resulting in a range of neurological, psychiatric, and …
verfasst von:
Stella Karantzoulis, Karli Heuer, Nicole Sparling, Brian Meltzer, Megan Teynor
According to the Centers for Disease Control and Prevention (CDC), the estimated prevalence of obesity in adults in the USA in 2020 was nearly 42% [ 1 ]. Obesity or overweight (defined as accumulation of excess fat that is detrimental to health) …
verfasst von:
Jiat Ling Poon, Louise OHara, Helen Kendal, Kate Sully, Margaret Guy, Helena Bradley, Chloe Tolley, Brad Mason
The landscape of immune-mediated disorders includes dermatological, gastrointestinal, and rheumatological diseases. Patients with these disorders can suffer from disabling symptoms and significant complications; there remains significant unmet …
verfasst von:
Rose J. Hart, Fareen Hassan, Sarah Alulis, Karl W. Patterson, Jennifer Norma Barthelmes, Jennifer H. Boer, Dawn Lee
Asthma treatment guidelines and the Global Initiative for Asthma strategy document classify inhaled corticosteroid (ICS) regimens via low-, medium-, and high-dose categories [ 1 , 2 ], often with reference to the now discontinued beclomethasone …
verfasst von:
Peter T. Daley-Yates, Bhumika Aggarwal, Maximilian Plank
Inflammatory and metabolic comorbidities (e.g., central and peripheral inflammation, obesity, insulin resistance, and diabetes mellitus) frequently co-occur and share pathophysiologic features with chronic psychiatric disorders such as major …
verfasst von:
Angela T. H. Kwan, Ziji Guo, Felicia Ceban, Gia Han Le, Sabrina Wong, Kayla M. Teopiz, Taeho Greg Rhee, Roger Ho, Joshua D. Di Vincenzo, Sebastian Badulescu, Shakila Meshkat, Bing Cao, Joshua D. Rosenblat, Giacomo d’Andrea, Donovan A. Dev, Lee Phan, Mehala Subramaniapillai, Roger S. McIntyre
Overactive bladder (OAB) is a chronic disorder that affects approximately 30% of adults ≥ 65 years old, and the prevalence increases with age [ 1 , 2 ]. The symptoms of OAB include urinary urgency, increased daytime urinary frequency, and/or …
verfasst von:
Benjamin Chastek, Adam Carrera, Christina Landis, Daniel Snyder, Laleh Abedinzadeh, Tim Bancroft, Jeffrey Nesheim, Michael Kennelly, David Staskin
Lung cancer is the most common cause of cancer mortality worldwide, with an estimated 1.80 million deaths annually [ 1 ]. Non-small cell lung cancer (NSCLC) accounts for 81% of all lung cancers [ 2 ]. More than half of newly diagnosed patients with …
verfasst von:
Mustafa Khasraw, Priyanka Yalamanchili, Anu Santhanagopal, Chuntao Wu, Maribel Salas, Jie Meng, Maha Karnoub, Stephen Esker, Enriqueta Felip
Humira ® (Adalimumab; AbbVie Inc., North Chicago, IL, USA [REF-ADL]) is a fully human immunoglobulin G1 (IgG1) monoclonal antibody targeting tumor necrosis factor alpha (TNF-α) [ 1 , 2 ]. Adalimumab is highly specific for TNF-α, binding to no other …
verfasst von:
Norman Gaylis, Charlotte Both, Lena Lemke, Oliver von Richter, Paul Yamauchi
This article is published with digital features, including a graphical abstract, to facilitate understanding of the article. To view digital features for this article, go to https://doi.org/10.6084/m9.figshare.25273465 .
verfasst von:
Eun-Gyoung Hong, Kyung-Wan Min, Jung Soo Lim, Kyu-Jeung Ahn, Chul Woo Ahn, Jae-Myung Yu, Hye Soon Kim, Hyun Jin Kim, Won Kim, Dong Han Kim, Hak Chul Jang
