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World Journal of Pediatrics OnlineFirst articles

11.12.2018 | Original Article

Changes of feeding patterns in Chinese city children under 2 years from 1985 to 2015: results from a series of national cross-sectional surveys

Early life nutrition is fundamental to children’s growth and development. Malnutrition is related to 35% of children’s deaths under 5 years of age worldwide. Improved breastfeeding has been shown to reduce infant mortality by 13% and reasonable …

Hua-Hong Wu, Ya-Qin Zhang, Xin-Nan Zong, Hui Li

05.12.2018 | Original Article

Effect of metoclopramide administration to mothers on neonatal bilirubin and maternal prolactin: a randomized, controlled, clinical trial

Jaundice is a common neonatal problem [ 1 ]. Bilirubin is predominantly produced following hemoglobin breakdown in the red blood cells or its hemolysis, which lead to the production of heme. Heme is catabolized by heme-oxygenase into biliverdin.

Shirin Osouli Tabrizi, Mojgan Mirghafourvand, Abdollah Jannat Dost, Sakineh Mohammad-Alizadeh-Charandabi, Yousef Javadzadeh, Robabe Seyedi

30.11.2018 | Original Article

Pediatric off-label use of psychotropic drugs approved for adult use in Japan in the light of approval information regarding pediatric patients in the United States: a study of a pharmacy prescription database

Drug development in pediatric populations is said to be a “therapeutic orphan”, which means that there is almost no evidence for the use of certain drugs among the pediatric population due to various problems [ 1 , 2 ]: (1) each age category (e.g. …

Nanae Tanemura, Maika Asawa, Mayuko Kuroda, Tsuyoshi Sasaki, Yoshiaki Iwane, Hisashi Urushihara

29.11.2018 | Original Article

Features distinguishing juvenile idiopathic arthritis among children with musculoskeletal complaints

Musculoskeletal (MSK) diseases comprise multiple disorders affecting the joints, bones, muscles, and soft tissues. Children with MSK diseases may present with joint pain, limb pain, morning stiffness, refusal to walk, and/or limping with or …

Satita Jeamsripong, Sirirat Charuvanij

26.11.2018 | Original Article Open Access

How online ADHD-related information affects Chinese parents’ decisions?

Attention-deficit hyperactivity disorder (ADHD) is a major public health concern. Systematic reviews indicate that the community prevalence globally is between 2% and 7%, with an average of around 5.5% [ 1 – 3 ]. There are approximately 10 million …

Xiao-He Yu, Le Zhong, Jia Huang

23.11.2018 | Original Article

Comparison of decision-making in neonatal care between China and Japan

China and Japan are close neighbors with strong economic ties. The latest Japanese government survey reported that about 770,000 Chinese nationals were living in Japan as of June 2017 and that about 130,000 Japanese nationals were living in China …

Hidehiko Maruyama, Yuka Shibata, Xing-Ge Xia, Yun-Xia Sun, Shao-Ru He, Yushi Ito

21.11.2018 | Original Article

Transcutaneous bilirubin nomogram for evaluating the risk of hyperbilirubinemia in Iranian healthy newborns

Hyperbilirubinemia is a common neonatal problem and cause of concern for parents and caregivers [ 1 , 2 ]. Jaundice is the most common cause of infants’ hospitalization in the first month after birth. More than half of the term infants and …

Robabe Seyedi, Mojgan Mirghafourvand, Abdollah Jannat Dost, Sakineh Mohammad-Alizadeh-Charandabi, Mohammad Asghari Jafarabadi, Shirin Osouli Tabrizi

21.11.2018 | Review Article

Liver fibrosis in biliary atresia

Biliary atresia (BA) is characterized by progressive inflammation and fibrotic sclerosis of the biliary tree. It is the most common cause of obstructive jaundice in infants. Children who are not treated usually die before age 2 years because of …

Wen-Jun Shen, Gong Chen, Min Wang, Shan Zheng

19.11.2018 | Review Article

Complications in children with percutaneous endoscopic gastrostomy (PEG) placement

Childhood is a very dynamic period in growth and development during which the body needs a lot of different micro- and macronutrients. Long-term eating disorders, dysphagia, malabsorption or maldigestion can lead to severe malnutrition. Long-term …

Brigitta Balogh, Tamás Kovács, Amulya Kumar Saxena

19.11.2018 | Original Article

Effect of vitamin D treatment in children with attention-deficit hyperactivity disorder

Attention-deficit hyperactivity disorder (ADHD) is a behavioral disorder defined by the following symptoms such as inattention, hyperactivity, impulsivity and restlessness [ 1 , 2 ]. The prevalence of ADHD in children is 5.3% [ 3 ]. ADHD affects …

Nadia Dehbokri, Gholamreza Noorazar, Aida Ghaffari, Gita Mehdizadeh, Parvin Sarbakhsh, Saba Ghaffary

16.11.2018 | Review Article

Current perspectives on the correlation of nocturnal enuresis with obstructive sleep apnea in children

Nocturnal enuresis (NE) is defined as intermittent incontinence while asleep in a child who is at least 5 years of age [ 1 ]. In general, NE is not considered a clinical problem when the number of wet nights is less than one per month [ 2 ]. For a …

Miao-Shang Su, Li Xu, Wen-Feng Pan, Chang-Chong Li

16.11.2018 | Original Article

Reliability and validity of the translated Chinese version of Autism Spectrum Rating Scale (2–5 years)

Autism is a group of neurodevelopmental disorders that are characterized by serious impairments of social communication, restricted and repetitive behaviors, and narrow interests [ 1 ]. This condition was first reported by Kanner in 1943 and is …

Hao Zhou, Chun-Pei Li, Yi Huang, Xiao-Bing Zou, Xue-Rong Luo, Li-Jie Wu, Lan Zhang, Xiu Xu, Wei-Li Yan, Yi Wang

16.11.2018 | Original Article

Long-term prognosis of low-risk neuroblastoma treated by surgery alone: an experience from a single institution of China

Neuroblastoma is the most common extracranial solid tumor in children. Its clinical manifestations, treatment effects, and prognosis are closely associated with the biological and histological characteristics of the tumor [ 1 , 2 ]. The Children’s …

Wei Yao, Kai Li, Kui-Ran Dong, Shan Zheng, Xian-Min Xiao

15.11.2018 | Original Article

Application of isoxanthopterin as a new pterin marker in the differential diagnosis of hyperphenylalaninemia

Hyperphenylalaninemia (HPA) is caused mainly by deficiency of phenylalanine hydroxylase (PAHD) and deficiency of its cofactor, tetrahydrobiopterin (BH4D). BH4D is an autosomal recessive genetic disease which is caused by defects in one of the five …

Pei-Zhong Bao, Jun Ye, Lian-Shu Han, Wen-Juan Qiu, Hui-Wen Zhang, Yong-Guo Yu, Jian-Guo Wang, Xue-Fan Gu

07.11.2018 | Original Article

Characteristics and outcome of newborn admitted with acute bilirubin encephalopathy to a tertiary neonatal intensive care unit

Neonatal hyperbilirubinemia occurs in more than 84% of late preterm and term newborns, peaking at 3–5 days of life and usually resolving by 2 weeks of age [ 1 ].

Nahed Fahmy Helal, Eman Abdel Ghany Abdel Ghany, Walaa Alsharany Abuelhamd, Amna Yehea Ahmed Alradem

20.10.2018 | Review Article

An update on the role of RANKL–RANK/osteoprotegerin and WNT-ß-catenin signaling pathways in pediatric diseases

Bone remodeling and appropriate growth are controlled by genetic factors, hormones, nutritional status, vitamin D levels, and exercise. In particular, bone strength is mainly determined by the peak of bone mass achieved during childhood and …

Giacomina Brunetti, Gabriele D’Amato, Mariangela Chiarito, Apollonia Tullo, Graziana Colaianni, Silvia Colucci, Maria Grano, Maria Felicia Faienza

27.09.2018 | Original Article

Comparison of the demographic characteristics of pediatric and adult colorectal cancer patients: a national inpatient sample based analysis

Colorectal cancer (CRC) in children is rare with an estimated annual incidence of 1 in 10 million adolescents younger than 20 years old [ 1 ]. Colorectal cancer is the most common primary gastrointestinal malignancy in children. Because of its …

Thomas M. Attard, Caitlin E. Lawson

22.09.2018 | Correction

Correction to: Phlegmonous appendicitis in children is characterized by eosinophilia in white blood cell counts

The original article can be found online.

Maximiliane I. Minderjahn, Dag Schädlich, Josephine Radtke, Karin Rothe, Marc Reismann

20.03.2018 | Letter to the Editor

Children with abnormal DMSA nuclear scan present a higher risk of recurrent febrile urinary tract infections

Luke Harper, Yan Lefevre, Xavier Delforge, David Bourquard, Cyril Ferdynus

06.03.2014 | Original Article

Effect of pravastatin on endothelial dysfunction in children with medium to giant coronary aneurysms due to Kawasaki disease